WORKSHOP BOOK Fluorescent in Situ Hybridisation - FISH - on Human Sperm
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Reciprocal Translocati<strong>on</strong><br />
The most frequent structural alterati<strong>on</strong>s <str<strong>on</strong>g>in</str<strong>on</strong>g><br />
humans and am<strong>on</strong>g <str<strong>on</strong>g>in</str<strong>on</strong>g>fertile males<br />
Carriers produce more unbalanced<br />
spermatozoa than normal or balanced<br />
spermatozoa (Moretti et al, 2009)<br />
55% of the gametes produced by carriers<br />
will be unbalanced (Bennet et al, 2005)<br />
Hands-<strong>on</strong> Workshops, Thessal<strong>on</strong>iki, 30.08 – 05.09 2014<br />
13<br />
Roberts<strong>on</strong>ian Translocati<strong>on</strong><br />
<br />
Carriers show impaired gametogenesis<br />
to a variable degree<br />
<br />
66% of the gametes are expected to be<br />
unbalanced; average of 15% is observed<br />
Frydman et al, 2001; Ogur et al, 2006<br />
Hands-<strong>on</strong> Workshops, Thessal<strong>on</strong>iki, 30.08 – 05.09 2014<br />
14