WORKSHOP BOOK Fluorescent in Situ Hybridisation - FISH - on Human Sperm
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Aneuploidy <str<strong>on</strong>g>in</str<strong>on</strong>g> male <str<strong>on</strong>g>in</str<strong>on</strong>g>fertile patients<br />
General populati<strong>on</strong><br />
Males with abnormal karyotypes<br />
Infertile males with normal karyotypes<br />
Males exposed to certa<str<strong>on</strong>g>in</str<strong>on</strong>g> envir<strong>on</strong>mental/life style hazards<br />
Risk reducti<strong>on</strong><br />
Future<br />
Hands-<strong>on</strong> Workshops, Thessal<strong>on</strong>iki, 30.08 – 05.09 2014<br />
21<br />
Infertile males (46, XY)<br />
After more than a decade of analysis and data collecti<strong>on</strong> it is clear<br />
that <str<strong>on</strong>g>in</str<strong>on</strong>g>fertile men with a normal somatic karyotype have an<br />
<str<strong>on</strong>g>in</str<strong>on</strong>g>creased risk of sperm aneuploidy<br />
The risk of produc<str<strong>on</strong>g>in</str<strong>on</strong>g>g chromosomally abnormal sperm <str<strong>on</strong>g>in</str<strong>on</strong>g>creases<br />
proporti<strong>on</strong>ally with the severity of the male <str<strong>on</strong>g>in</str<strong>on</strong>g>fertility<br />
Sanchez-Castro et al, 2009; Sarrate et al, 2009, Templado et al, 2013<br />
Hands-<strong>on</strong> Workshops, Thessal<strong>on</strong>iki, 30.08 – 05.09 2014<br />
22
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