WORKSHOP BOOK Fluorescent in Situ Hybridisation - FISH - on Human Sperm
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<str<strong>on</strong>g>FISH</str<strong>on</strong>g>: What can it offer?<br />
Identifies chromosomal abnormalities<br />
by view<str<strong>on</strong>g>in</str<strong>on</strong>g>g a segment or entire chromosome<br />
with your own eyes dur<str<strong>on</strong>g>in</str<strong>on</strong>g>g Meta-phase,<br />
and Inter-phase<br />
A variety of specimen types can be analysed<br />
5<br />
<str<strong>on</strong>g>FISH</str<strong>on</strong>g>: How?<br />
DNA nucleic acid probe is hybridised<br />
to a target DNA sequence<br />
The <str<strong>on</strong>g>in</str<strong>on</strong>g>tact cells are attached<br />
to a microscope slide<br />
us<str<strong>on</strong>g>in</str<strong>on</strong>g>g standard cytogenetic methods<br />
6
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