WORKSHOP BOOK Fluorescent in Situ Hybridisation - FISH - on Human Sperm
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Mechanisms aga<str<strong>on</strong>g>in</str<strong>on</strong>g>st sperm aneuploidy<br />
The differences between the paternal and maternal c<strong>on</strong>tributi<strong>on</strong><br />
to aneuploidy are rather due to more effective checkpo<str<strong>on</strong>g>in</str<strong>on</strong>g>t<br />
mechanisms <str<strong>on</strong>g>in</str<strong>on</strong>g> spermatogenesis than <str<strong>on</strong>g>in</str<strong>on</strong>g> oogenesis (Uroz et al,<br />
2012; Templado, 2013)<br />
It is well known that dur<str<strong>on</strong>g>in</str<strong>on</strong>g>g spermatogenesis various checkpo<str<strong>on</strong>g>in</str<strong>on</strong>g>ts<br />
are activated to arrest cells with chromosome abnormalities,<br />
lead<str<strong>on</strong>g>in</str<strong>on</strong>g>g to a reducti<strong>on</strong> <str<strong>on</strong>g>in</str<strong>on</strong>g> gamete producti<strong>on</strong> and therefore the<br />
male <str<strong>on</strong>g>in</str<strong>on</strong>g>fertility (Egozcue et al, 2005)<br />
Inefficient c<strong>on</strong>trol mechanisms could therefore be <strong>on</strong>e<br />
explanati<strong>on</strong> for the <str<strong>on</strong>g>in</str<strong>on</strong>g>creased rate of chromosome abnormalities<br />
observed <str<strong>on</strong>g>in</str<strong>on</strong>g> some cases (Sarranate et al, 2009)<br />
Hands-<strong>on</strong> Workshops, Thessal<strong>on</strong>iki, 30.08 – 05.09 2014<br />
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