WORKSHOP BOOK Fluorescent in Situ Hybridisation - FISH - on Human Sperm
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<strong>Sperm</strong>-<str<strong>on</strong>g>FISH</str<strong>on</strong>g><br />
protocol<br />
17<br />
<strong>Sperm</strong> nuclear architecture<br />
Unique, well organized nuclear architecture<br />
different from somatic cells<br />
Extreme compactness of chromat<str<strong>on</strong>g>in</str<strong>on</strong>g><br />
1) each chromosome at dist<str<strong>on</strong>g>in</str<strong>on</strong>g>ct nuclear<br />
territory<br />
2) centromeres of n<strong>on</strong>-homologous<br />
chromosomes<br />
form chromocentres<br />
3) telomeres <str<strong>on</strong>g>in</str<strong>on</strong>g>teract with each other form<str<strong>on</strong>g>in</str<strong>on</strong>g>g<br />
dimers and tetramers<br />
18
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