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What's new AAPOS 2008 - The Private Eye Clinic

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PLASTICS<br />

Conjunctival epithelial changes induced by cilia in patients with epiblepharon or<br />

entropion.<br />

Kim C, Shin YJ, Kim NJ, Khwarg SI, Hwang JM, Wee WR.<br />

Am J Ophthalmol. 2007 Oct;144(4):564-9. Epub 2007 Aug 9.<br />

PURPOSE: To evaluate the effect of mechanical trauma induced by cilia on the<br />

conjunctival epithelium in patients with epiblepharon or entropion and to evaluate<br />

changes in epithelium after surgical correction in patients with entropion. DESIGN:<br />

Case-control study.<br />

METHODS: One hundred and seven eyes of 61 patients were enrolled in this study and<br />

were divided into three groups: the epiblepharon group (n = 59), the entropion group (n<br />

= 17), and the age-matched control group for the epiblepharon group (n = 31).<br />

Impression cytologic specimens were obtained from nasal and temporal bulbar<br />

conjunctiva of the epiblepharon and control groups immediately after the induction of<br />

general anesthesia. In the entropion group, these were obtained before and one month<br />

after surgical correction. Conjunctival changes were graded using the Tseng method<br />

and goblet cell densities were compared.<br />

RESULTS: Cytologic scores were significantly higher in the epiblepharon group than in<br />

the control group (P < .001), and goblet cell densities of nasal and temporal conjunctiva<br />

were significantly lower in the epiblepharon group than in the control group (P = .044<br />

and P = .018, respectively). In the entropion group, postoperative scores were<br />

significantly lower than preoperative scores in both conjunctival areas (P = .033 and P =<br />

.003, respectively). No statistically significant difference was found between nasal and<br />

temporal conjunctiva in the three groups.<br />

CONCLUSIONS: <strong>The</strong> persistent mechanical trauma by cilia in patients with<br />

epiblepharon or entropion can induce squamous metaplasia of the conjunctival<br />

epithelium. However, these conjunctival changes can be reversed by surgical<br />

correction.<br />

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