Vol 43 # 3 September 2011 - Kma.org.kw

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Characterization of Acrylamide Mediated Testicular Toxicity in Rat: Light and Electron ...
September 2011
Fig. 1: Shows the effects of different doses of AA on rats’ body
weight during the treatment period (day 1 - 5). There is a
statistically significant decrease in body weight (H = p < 0.05) of
the groups treated with 45 and 60 mg/kg AA.
that varied in its severity along with lethargy and
reduction in activity. None of these potential markers
of toxicity were present in the other treatment groups.
Effect of AA on rats' body weight
During the treatment period (day 1 - 5) there was a
statistically significant drop in body weight (p < 0.05)
in the groups of rats treated with 45 and 60 mg/kg AA.
(Fig.1). During the recovery period, (5 - 8 days) after
cessation of AA treatment, the loss of body weight
Fig. 2: Shows the effects of different doses of AA on rats’ body
weight during the recovery period (day 5 - 8), after cessation of AA
treatment. There is a statistically significant decrease in body weight
at AA doses of 45 and 60 mg/kg, (H = p < 0.05) and (HH = p < 0.01)
respectively, as compared to the control group.
became less pronounced with slight weight gain
occurring in some animals of all groups. However,
there was still a statistically significant decrease in
body weight at AA doses of 45 and 60 mg/kg, (p <
0.05) and (p < 0.01) respectively, as compared to the
control group (Fig. 2).
Effect of AA on testis / body weight ratio
This study revealed a significant increase (p < 0.05)
of the testis / body weight ratio in the group treated
Fig. 3: Shows effects of different doses of AA on rats’ testis / body
weight ratio at the end of the experiment. There is a significant
increase ( H = p < 0.05) in testis weight in relation to the body weight
of the rats in the group treated with 15 mg/kg AA. Moreover, a very
significant increase (HH = p < 0.01) in testis / body weight ratio
was detected in the two groups treated with 45 and 60 mg/kg.
Fig: 4: Shows the effects of different doses of AA on caudal sperm
count. There is significant reduction (H = p < 0.05) in sperm count
of the group treated with 60 mg/kg AA. Other groups showed no
difference in relation to control group.