Sundhedsvidenskabelig Forskning ved Aarhus - Institutleder til ...

BIRC, BIOINFORMATICS RESEARCH CENTER
matics Research Centre.
Thesis: Stochastic modelling of protein levels in guard
cells using stochastic Petri nets - forsvaret 14.
september 2009.
Ole Jørgensen, M.Sc, studerende, Department of Computer
Science, Aarhus Universitet. Thesis: Logic
Regression in Association Mapping – forsvaret 6.
maj, 2009.
Thu Hang Nguyen, M.Sc. studerende, Bioinformatics
Research Centre, Aarhus Universitet. Thesis: Comparison
of Multiple Sequence Alignment Programs
in Practise – forsvaret 17. februar, 2009.
Vigtigste satsningsområder inden for centrets forskning
• Mønstergenkendelse inden for sammenhænge
mellem sygdomme og arveanlæg
• Associationsstudier af komplekse sygdomme
• Statistisk afledning af DNA-kopital i cancer
• Statistisk analyse af array data
• Hypermuterbart DNA og cancer
• Modeller og statistisk analyser af biologiske
netværk
• Algoritmer til rekonstruktion og sammenligning
af fylogenetiske træer og netværk
• Algoritmer og datastrukturer til analyse og håndtering
af biologiske sekvensdata
• Effektive implementeringer af bioinformatiske
algoritmer og værktøjer
• Komparativ sekvensanalyse
• Molekyldynamiske simuleringer
• Udvikling af metoder til molekylær docking
Publikationer
Forskning
Artikel, peer-reviewed
Bertelsen, K, Jensen, BP, Thøgersen, L, Tajkhorshid, E,
Schiøtt, HB, Skrydstrup, T, Nielsen, NC & Vosegaard,
T 2009, ‘Residue-Specific Information about
the Dynamics of Antimicrobial Peptides from
1H−15N and 2H Solid-State NMR Spectroscopy’,
Journal of the American Chemical Society, vol. 131,
nr. 51, s. 18335–18342.
Bertioli, D, Moretzsohn, M, Madsen, L, Sandal, N, Leal-
Bertioli, S, Guimaraes, P, Hougaard, B, Fredslund,
J, Schauser, L, Nielsen, A, Sato, S, Tabata, S, Cannon,
S & Stougaard, J 2009, ‘An analysis of synteny
of Arachis with Lotus and Medicago sheds new
light on the structure, stability and evolution of legume
genomes’, BMC Genomics, vol. 10, nr. 1, s. 45.
Besenbacher, S, Mailund, T & Pedersen, CS 2009, ‘A
fast algorithm for genome wide haplotype pattern
mining’, BMC Bioinformatics, vol. 10, nr. S1.
Besenbacher, S, Mailund, T & Schierup, MH 2009,
‘Local phylogeny mapping of quantitative traits:
Higher accuracy and better ranking than single
marker association in genomewide scans’, Genetics,
vol. 181, s. 747-753.
Boggs, NA, Dwyer, KG, Shah, P, McCulloch, AA, Bechsgaard,
J, Schierup, MH, Nasrallah, ME & Nasrallah,
JB 2009, ‘Expression of distinct self-incompatibility
specificities in Arabidopsis thaliana’, Genetics,
vol. 182, nr. 4, s. 1313-21.
Dittmer, J, Thøgersen, L, Underhaug, J, Bertelsen, K,
Vosegaard, T, Pedersen, JM, Schiøtt, HB, Tajkhorshid,
E, Skrydstrup, T & Nielsen, NC 2009, ‘Incorporation
of Antimicrobial Peptides into Membranes:
A Combined Liquid-State NMR and Molecular
Dynamics Study of Alamethicin in DMPC/DHPC
Bicelles’, Journal of Physical Chemistry B, vol. 113,
nr. 19, s. 6928-6937.
Dutheil, J, Ganapathy, G, Hobolth, A, Mailund, T,
Uyenoyama, M & Schierup, MH 2009, ‘Ancestral
population genomics: the coalescent hidden
Markov model approach’, Genetics, vol. 183, nr. 1,
s. 259–274.
Emily, M, Mailund, T, Hein, J, Schauser, L & Schierup,
MH 2009, ‘Using biological networks to search for
interacting loci in genomewide association studies’,
European Journal of Human Genetics.
Glémin, S & Bataillon, T 2009, ‘A comparative view of
the evolution of grasses under domestication’,
New Phytologist, vol. 183, nr. 2, s. 273-90.
Guo, Y, Bechsgaard, JS, Slotte, T, Neuffer, B, Lascoux,
M, Weigel, D & Schierup, MH 2009, ‘Recent speciation
of Capsella rubella from Capsella grandiflora,
associated with loss of self-incompatibility and an
extreme bottleneck’, Proceedings of the National
Academy of Science of the United States of America,
vol. 106, nr. 13, s. 5246-51.
Hobolth, A & Stone, E 2009, ‘Simulation from endpointconditioned,
continuous-time Markov chains on a
finite state space, with applications to molecular
evolution’, Annals of Applied Statistics, vol. 3, nr. 3,
s. 1204-1231.
Hobolth, A & Wiuf, CH 2009, ‘The genealogy, site frequency
spectrum and ages of two nested mutant
alleles’, Theoretical Population Biology, vol. 75, nr.
4, s. 260-265.
Sundhedsvidenskabelig Forskning ved Aarhus Universitet og Århus Universitetshospital 2009 33