Sundhedsvidenskabelig Forskning ved Aarhus - Institutleder til ...

INSTITUT FOR MEDICINSK BIOKEMI
sygdomme.
• Medicinsk proteomanalyse til kortlægning af molekylære
mekanismer ved især cancer og hjerteog
karsygdomme.
• Transgene dyremodeller af humane sygdomme.
• Regulering af gen- og proteinexpression i det
befrugtede æg samt preimplantationsfostre.
• Albumin: Potentiale for udvikling af lægemidler.
Centre
Lundbeck-Fonden. Neuroforskningscentret MIND blev
etableret i 2005. Centret ledes af prof., Anders Nykjær.
Prof., dr.med. Poul Henning Jensens gruppe er del af
Nordic Centre of Excellence in Molecular Neurodegeneration
, Innovationskonsortiet Cure-ND, NEURASYN
(FP7 Academic-Industrial Training Network om Alpha-
Synuclein-related Brain Diseases) samt MEPOFA (FP7
colloborative project European Project on Mendelian
Formas of Parkinson’s disease.
Danish Center for Transgenic Mice ved Aarhus Universitet
ledes af prof., Ph.D. Anders Nykjær.
Karin Lykke-Hartmanns gruppe deltager i en del af
Grundforskningscentret PUMPKIN – Membranpumper
i celler og sygdom
Ph.d.-afhandlinger
Gustafsen, C 2009, Functional aspects of the Vps10pdomain
receptors Sortilin and SorLA, Ph.d.-afhandling,
Aarhus Universitet.
Hedegaard, C 2009, Towards a transgenic porcine model
of parkinson’s disease, Ph.d.-afhandling, Aarhus
Universitet.
Kragh, CL 2009, Cellular responses to soluble
ά-synuclein aggregates; Possible contributions to
ά-synucleinopathis, Ph.d.-afhandling, Aarhus Universitet.
Larsen, JV 2009, Modulation of Transmembrane Receptor
Function by Sortilin - Involvement in Helical
Type-1 Cytokine Signalling, Ph.d.-afhandling, Aarhus
Universitet.
Skeldal, S 2009, Functional interactions between the
Vps10p domain receptor family and their co-receptors,
Ph.d.-afhandling, Aarhus Universitet.
Publikationer
Forskning
Artikel, peer-reviewed
Botta, R, Lisi, S, Pinchera, A, Giorgo, F, Marcossi, C,
Taddei, A, Fausto, A, Bernardini, N, Ippolito, C,
Mattii, L, Persani, L, Filippis, TD, Calebiro, D,
Peder, PS, Petersen, CM & Marino, M 2009, ‘Sortilin
is a putative post-endocytic receptor of thyroglobulin’,
Endocrinology, nr. 150, s. 509-518.
Boysen, G, Krarup, L, Zeng, X, Oskedra, A, Kõrv, J,
Andersen, G, Gluud, C, Pedersen, A, Lindahl, M,
Hansen, L, Winkel, P, Truelsen, T & ExStroke Pilot
Trial Group 2009, ‘ExStroke Pilot Trial of the effect
of repeated instructions to improve physical activity
after ischaemic stroke: a multinational randomised
controlled clinical trial’, BMJ. British Medical
Journal (International Ed.), vol. 339, s. b2810.
Degn, SE, Hansen, A, Steffensen, R, Jacobsen, C, Jensenius,
JC & Thiel, S 2009, ‘MAp44, a human protein
associated with pattern recognition molecules of
the complement system and regulating the lectin
pathway of complement activation’, Journal of Immunology,
vol. 183, nr. 11, s. 7371-8.
Dolatshahi-Pirouz, A, Skeldal, S, Hovgaard, MB, Jensen,
THL, Foss, M, Chevallier, J & Besenbacher,
F 2009, ‘Influence of nano-roughness and the
detailed surface morphology on the structural
properties and water coupling capabilities of
surface bound fibrinogen films’, Journal of Physical
Chemistry C, vol. 113, nr. 11, s. 4406.
Dolatshahi-Pirouz, A, Pennisi, CP, Skeldal, S, Foss, M,
Chevallier, J, Zachar, V, Andreasen, P, Yoshida, K
& Besenbacher, F 2009, ‘The Influence of glancing
angle deposited (GLAD) nano-rough platinum
surfaces on the adsorption of fibrinogen and the
proliferation of primary human fibroblasts’, Nanotechnology,
vol. 20, s. 095101.
Eriksen, J, Rasmussen, SG, Rasmussen, TN, Vægter,
CB, Cha, JH, Zou, M, Newman, AH & Rasmussen,
TN 2008, ‘Visualization of dopamine transporter
trafficking in live neurons by use of fluorescent
cocaine analogues’, Journal of Neuroscience, vol.
29, nr. 21, s. 6798-6808.
Hansen, GW, Vorum, H, Jacobsen, C & Honoré, B 2009,
‘Calumenin but not reticulocalbin forms a Ca2+dependent
complex with thrombospondin-1. A
potential role in haemostasis and thrombosis’,
Molecular and Cellular Biochemistry, vol. 320, nr.
1-2, s. 25-33.
Hansen, JH, Petersen, SV, Andersen, KK, Enghild, JJ,
Damhus, T & Otzen, D 2009, ‘Stable intermediates
determine proteins’ primary unfolding sites in the
presence of surfactants’, Biopolymers, vol. 91, nr. 3,
s. 221-31.
Hedegaard, C, Bendixen, E, Jensen, PH, Bendixen, C &
76 Sundhedsvidenskabelig Forskning ved Aarhus Universitet og Århus Universitetshospital 2009