Sundhedsvidenskabelig Forskning ved Aarhus - Institutleder til ...

KLINISK INSTITUT
cand.med. Lasse Solskov Jensen
cand.med. Mikkel Holm Vendelbo
cand.med. Mads Buhl
cand.med. Ulrick Espelund
cand.med. Michael Geil
cand.med. Ulrick Espelund
cand.scient. Thomas Svava Nielsen
Forskningsårsstuderende
stud. med. Thomas Korgaard Jensen
stud. med. Berthil F. Clasen
Seniorforskere
Post.doc., ph.d. Mette Bjerre
Post.doc., ph.d. Niels Jessen
Post.doc., ph.d. Nils Magnusson
Vigtigste satsningsområder inden for afdelingens
forskning
• Tidlig opsporing og klinisk håndtering af sendiabetiske
komplikationer
• Patogenese af sen-diabetiske komplikationer
– med specielt fokus på molekylærbiologiske
mekanismer
• Udvikling af nye biomarkører for kardiovaskulær
sygdom
• Patogenese af type 2 diabetes - med særlig fokus
på insulinsekretion og insulinvirkning
• Intermediær metabolisme
• Væksthormon (GH)-IGF aksen og den metaboliske
effekt af forskellige fysiologiske og patofysiologiske
konditioner, herunder faste, aldring og
fedme
• Fysisk aktivitet og metabolisme
• Kliniske og metaboliske aspekter af væksthormonmangel
og substitutionsbehandling
• Thyroideahormoner og stofskiftet
• Udvikling af immunologiske assays
Ph.d.-afhandling
Jensen, L 2009, Protection against myocardial
ischaemia-reperfusion injury by activators of AMPactivated
protein kinase (AMPK), Ph.d.-afhandling,
Aarhus Universitet.
Publikationer
Forskning
Artikel, peer-reviewed
Aagaard, NK, Grøfte, T, Greisen, J, Malmlöf, K, Johansen,
PB, Grønbæk, H, Ørskov, H, Tygstrup, N &
Vilstrup, H 2009, ‘Growth hormone and growth
hormone secretagogue effects on nitrogen balance
and urea synthesis in steroid treated rats’, Growth
Hormone & IGF Research, vol. 19, nr. 5, s. 426-31.
Andersen, O, Hansen, BR, Troensegaard, W, Flyvbjerg,
A, Madsbad, S, Ørskov, H, Nielsen, JO, Iversen, J
& Haugaard, SB 2009, ‘Sustained low-dose growth
hormone therapy optimizes bioactive insulin-like
growth factor-I level and may enhance CD4 T-cell
number in HIV infection’, Journal of Medical Virology,
vol. 82, nr. 2, s. 197-205.
Andreassen, CS, Jakobsen, J, Flyvbjerg, A & Andersen,
H 2009, ‘Expression of neurotrophic factors in diabetic
muscle--relation to neuropathy and muscle
strength’, Brain, vol. 132, nr. pt. 10, s. 2724-33.
Bjerre, M, Hansen, TK, Flyvbjerg, A & Tønnesen, E
2009, ‘Simultaneous detection of porcine cytokines
by multiplex analysis: Development of magnetic
bioplex assay’, Veterinary Immunology and
Immunopathology, vol. 130, nr. 1-2, s. 53-8.
Buhl, M, Gjedsted, J, Granfeldt, A, Larsen, PØ, Chew,
M, Møller, N & Tønnesen, E 2009, ‘Circulating Free
Fatty Acids do not Contribute to the Acute Systemic
Inflammatory Response. An Experimental
Study in Porcine Endotoxaemia’, Basic & Clinical
Pharmacology & Toxicology, vol. 105, nr. 5, s. 319-
326.
Ejskjaer, N, Vestergaard, ET, Hellström, PM, Gormsen,
LC, Madsbad, S, Madsbad, S, Madsen, JL, Jensen,
TA, Pezzullo, JC, Christiansen, JS, Shaughnessy, L
& Kosutic, G 2009, ‘Ghrelin receptor agonist (TZP-
101) accelerates gastric emptying in adults with
diabetes and symptomatic gastroparesis’, Alimentary
Pharmacology and Therapeutics, vol. 29, nr. 11,
s. 1179-87.
Finucane, F, Luan, J, Wareham, N, Sharp, S, O’Rahilly,
S, Balkau, B, Flyvbjerg, A, Walker, M, Højlund, K,
Nolan, J, (on behalf of the European Group for the
Study of Insulin Resistance: Relationship between
Insulin Sensitivity and Cardiovascular Disease
Risk Study Group) & Savage, D 2009, ‘Correlation
of the leptin:adiponectin ratio with measures of
insulin resistance in non-diabetic individuals’,
Diabetologia, vol. 52, nr. 11, s. 2345-2349.
Frederiksen, L, Nielsen, TL, Wraae, K, Hagen, C,
Frystyk, J, Flyvbjerg, A, Brixen, K & Andersen, M
2009, ‘Subcutaneous Rather than Visceral Adipose
Tissue Is Associated with Adiponectin Levels
and Insulin Resistance in Young Men’, Journal of
Sundhedsvidenskabelig Forskning ved Aarhus Universitet og Århus Universitetshospital 2009 99