SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M PROGRAM LEADER Michael H. Antoni, Ph.D. Professor of Psychology DESCRIPTION OF PROGRAM The Cancer Prevention and Control Program is composed of 23 faculty members in nine different departments at the University of Miami. The program, which builds on earlier work, includes research in cancer etiology, prevention, early detection, education/outreach, cancer genetics, quality of life, survivorship, psychoneuroimmunology, and biobehavioral interventions. Specific studies underway at this time include the use of tobacco, assessment of quality of life among persons who have been treated for cancer, stress management intervention in persons recently diagnosed with cancer, investigations of cancer incidence in Florida, outreach to Hispanic populations, and implementation of cancer control strategies. The projects performed by members of the Cancer Prevention and Control Program vary substantially. Some are purely behavioral or psychosocial in their aims; others examine neuroendocrine and immunological mechanisms relevant for disease promotion and/or progression. Most of these projects entail collaboration among behavioral scientists, surgeons, and oncologists. Others involve collaboration among psychologists, epidemiologists, immunologists, biochemists, and other biomedical scientists. GOALS OF PROGRAM 1) Determine the predictors of cancer risk behavior in vulnerable populations and then develop and evaluate culturally competent interventions to prevent cancer in clinical and community populations. 2) Develop and evaluate psychosocial interventions designed to reduce stress, enhance quality of life, and improve compliance as well as other health-related behaviors and biological processes associated with health outcomes. 3) Examine the interactive effects of stress, behavior, and psychosocial components on neuroendocrine and immune function in cancer patients and in at-risk populations. Determine how these vary across sites, gender, age, race/ ethnicity, and prognostic variables. 4) Better understand the risk factors for recurrence, enhancing quality of life, the role of the family in survival, preventing second malignancies and the sequelae of cancer treatment, and gain a better understanding of potential psychosocial influences on biological processes that may be involved in cancer recurrence. 5) Develop and evaluate methods of disseminating cancer information and education for diverse communities. PARTICIPANTS Antoni, Michael H., Ph.D. Psychology Armstrong, F. Daniel, Ph.D. Pediatrics Baumbach-Reardon, Lisa L., Ph.D. Pediatrics Blomberg, Bonnie B., Ph.D. Microbiology and Immunology Carver, Charles S., Ph.D. Psychology Fleming, Lora E., M.D., Ph.D., M.P.H., M.Sc. Epidemiology and Public Health UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 1
C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M Fletcher, Mary Ann A., Ph.D. Microbiology and Immunology Goodman, Kenneth W., Ph.D. Medicine Goodwin, W. Jarrard, M.D., F.A.C.S. Otolaryngology Ironson, Gail H., M.D., Ph.D. Psychology Kirsner, Robert S., M.D. Dermatology and Cutaneous Surgery Kumar, Mahendra, Ph.D. Psychiatry and Behavioral Sciences Lechner, Suzanne C., Ph.D. Psychiatry and Behavioral Sciences Lee, David J., Ph.D. Epidemiology and Public Health Levis-Dusseau, Silvina, M.D. Medicine McCoy, Clyde B., Ph.D. Epidemiology and Public Health Penedo, Frank J., Ph.D. Psychology Roos, Bernard A., M.D. Medicine Schlesselman, James J., Ph.D. Epidemiology and Public Health Schneiderman, Neil, Ph.D. Psychology Shor-Posner, Gail S., Ph.D. Psychiatry and Behavioral Sciences Twiggs, Leo B., M.D. Obstetrics and Gynecology Wilkinson, James D., M.D., M.P.H. Epidemiology and Public Health HIGHLIGHTS Breast Cancer African-American women with pre-menopausal breast cancer have characteristic mutations and polymorphic variants not observed in Caucasians. In addition, the frequency of BRCA1 and BRCA2 germ-line “deleterious” mutations is much less than that observed in Caucasians. Overall, breast cancer in African-American women occurs at a younger age, is more often estrogen receptor negative, and more frequently exhibits aggressive biological behaviors. Breast Cancer Screening After controlling for demographic variables traditionally related to breast cancer screening rates, there are ethno-regional differences in breast cancer screening and Pap smear practices among Cubans, Mexican-Americans, Puerto Ricans, Central Americans, and South Americans across the United States. Social integration appears to influence participation in cancer screening among Hispanic women. The modest effect is not universal across Hispanic groups and is stronger for Pap smear than for mammography screening behavior. Florida Comprehensive Cancer Control Initiative The Florida Comprehensive Cancer Control Initiative (FCCCI) was established in October 2000 as the result of a federal appropriation and funding from the CDC’s Comprehensive Cancer Control Program. The CDC’s funding ended in June 2003, but the program continues as a departmental resource for expanding UM/Sylvester’s community-based cancer control research program. During the two and one-half years the FCCCI was funded by CDC, it established four regional cancer control collaboratives that cover the entire state of Florida. Each collaborative engaged in a strategic planning process and developed a comprehensive cancer control plan for their respective regions (http://fccci.med.miami.edu). More than 200 individuals and 100 organizations participated in the planning process, which has been integrated into the state’s cancer control planning 2 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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G L O S S A R Y IFN—interferon IL
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SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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