SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

C L I N I C A L O N C O L O G Y R E S E A R C H P R O G R A M
the ER protein half-life was reduced in ERbreast
cancer lines. These data support a model
in which Her2 and cSrc cooperate with liganded
ER to promote both ER dependent transcription
and transcription linked ER proteolysis.
SELECTED PUBLICATIONS
2002
Donovan, JC, Rothenstein, JM, and Slingerland,
JM. Non-malignant and tumor-derived cells differ
in their requirement for p27Kip1 in transforming
growth factor-beta-mediated G1 arrest.
Journal of Biological Chemistry 277:41686-92,
2002.
Lian, J, Zubovitz, J, Petrocelli, T, Kotchetkov, R,
Connor, MK, Han, K, Lee, JH, Ciarallo, S,
Catzavelos, C, Beniston R, Franssen, E, and
Slingerland, JM . PKB/Akt phosphorylates p27,
impairs nuclear import of p27 and opposes p27-
mediated G1 arrest. Nature Medicine 8:1153-60,
2002.
Ciarallo, S, Subramaniam, V, Hung, W, Lee, JH,
Kotchetkov, R, Sandhu, C, Milic, A, and
Slingerland, JM . Altered p27(Kip1) phosphorylation,
localization, and function in human epithelial
cells resistant to transforming growth
factor beta-mediated G(1) arrest. Molecular and
Cellular Biology 22:2993-3002, 2002.
2003
Connor, MK, Kotchetkov, R, Cariou, S, Resch,
A, Lupetti, R, Beniston, RG, Melchior, F,
Hengst, L, and Slingerland, JM . CRM1/Ranmediated
nuclear export of p27(Kip1) involves a
nuclear export signal and links p27 export and
proteolysis. Molecular Biology of the Cell
14:201-13, 2003.
Liang, J and Slingerland, JM . Multiple Roles of
the PI3K/PKB (Akt) Pathway in cell cycle progression.
Cell Cycle 2:339-45, 2003.
MARK S. SOLOWAY, M.D.
Professor and Chairman of Urology
DESCRIPTION OF RESEARCH
Much of the work in the University of
Miami’s department of Urology is devoted
to better understanding the role of surgery in
treating prostate, bladder, and kidney cancers.
The department has established a rather unique
database of more than 1,300 men who have had
radical prostatectomy performed by one surgeon
and their pathology has been read by one pathologist.
Through the efforts of devoted researchers,
they have reported on the relationship
between a number of clinical and pathologic risk
factors, e.g., positive surgical margin location,
seminal vesicle invasion, and risk of relapse. This
is critical when counseling patients regarding diagnosis,
follow-up schedule and, most importantly,
the need and type of additional treatment.
Researchers in Dr. Soloway’s laboratory have
introduced the concept of local anesthesia for
prostate biopsies. This has the potential to benefit
more than 500,000 men annually in the United
States who undergo this otherwise rather painful
procedure. More than 13 randomized studies
confirm the researchers’ observation of the benefit
of a periprostatic nerve block prior to ultrasound
guided prostate biopsies.
In an effort to minimize the morbidity of
radical retropubic prostatectomy, Dr. Soloway has
taken steps to enhance recovery without sacrificing
cancer control. To this end, he has reported
his results with nerve sparing, the omission of a
pelvic drain, and the use of a cell saver to obviate
the need for an allogeneic transfusion.
In collaboration with Gaetano Ciancio,
M.D., professor of Surgery and Urology, they
have carefully detailed their surgical approach to
large kidney tumors. They have adapted techniques
developed for liver transplantation to reduce
the morbidity and mortality related to
surgery of large renal tumors, many of which involve
extension into the vena cava.
UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 59