SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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C L I N I C A L O N C O L O G Y R E S E A R C H P R O G R A M LEONIDAS G. KONIARIS, M.D., F.A.C.S. Associate Professor of Surgery DESCRIPTION OF RESEARCH Dr. Koniaris’ research concentrates on the mechanism of growth control and deregulation in vivo in the gastrointestinal (GI) tract and breast. In particular, he has focused on the role of two secreted factors—interleukin-6 (IL-6) and macrophage inflammatory cytokine-1 (MIC-1). IL-6 is a pro-inflammatory cytokine essential in normal liver homeostasis. Investigators in the laboratory have recently demonstrated that IL functions as a growth factor for hepatocytes through an apparent direct mechanism that does not involve activation of cMET or epidermal growth factor (EGF). Subsequent work has demonstrated that this mitogenic response is associated with profound anti-apoptotic activity. Other work from the laboratory has examined how the IL-6 response affects insulin signaling and contributes to the hepatocellular dysfunction seen in chronic liver disease. In addition, they are examining the effects of IL-6 on hepatocellular carcinoma with collaborators at the University of North Carolina. MIC-1 is a divergent member of the transforming growth factor-beta (TGF-β) superfamily of growth and differentiation factors. MIC-1 strongly has been implicated in the pathogenesis of both colorectal and prostate cancers and may have a potent anti-tumor function. The laboratory has examined the expression of MIC-1 and found it to be an immediate early response to a variety of organ injuries and exposures to carcinogens. They have generated MIC-1 null mice and are examining their propensity to the development of liver, colorectal, breast, and prostate cancers. SELECTED PUBLICATIONS 2002 Barreiro, CJ, Lillemoe, KD, Koniaris, LG, Sohn, TA, Yeo, CJ, Coleman, J, Fishman, EK, and Cameron, JL. Diagnostic laparoscopy for periampullary and pancreatic cancer: what is the true benefit? Journal of Gastrointestinal Surgery 6:75-81, 2002. Kovach, SJ, Hendrickson, RJ, Cappadona, CR, Schmidt, CM, Groen, K, Koniaris, LG, and Sitzmann, JV. Cryoablation of unresectable pancreatic cancer. Surgery 131:463-64, 2002. Sayeed, S, Koniaris, LG , and Papadakos, PJ. Image of the month. Acute respiratory distress syndrome. Archives of Surgery 137:491-92, 2002. Abt, PL, Halaby, I, Schoeniger, LO, and Koniaris, LG. Intrahepatic gas. Journal of the American College of Surgeons 195:129, 2002. Cirillo, RL Jr. and Koniaris, LG. Detecting blunt pancreatic injuries. Journal of Gastrointestinal Surgery 6:587-98, 2002. Hendrickson, RJ, Koniaris, LG, Kovach, SJ, and Johnson, JA. Gamma probe-confirmed laparoscopic accessory splenectomy. Surgical Endoscopy 16:1364, 2002. Hendrickson, RJ, Koniaris, LG, Schoeniger, LO, Strang, J, Killackey, MA, and Peacock, JL. Small bowel obstruction due to a paracolonic retroperitoneal hernia. American Journal of Surgery 68:756-58, 2002. Sayeed, S, Koniaris, LG , Kovach, SJ, and Hirokawa, T. Torsion of a wandering spleen. Surgery 132:535-36, 2002. Ognibene. SJ, Koniaris. LG, Pegoli, W Jr., and Drugas, GT. Intraoperative colonic lavage in a premature infant: a case report. Journal of Pediatric Surgery 37:1645-47, 2002. UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 39
C L I N I C A L O N C O L O G Y R E S E A R C H P R O G R A M Price, JA, Kovach, SJ, Johnson, T, Koniaris, LG , Cahill, PA, Sitzmann, JV, and McKillop, IH. Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Hepatology 36:1089- 97, 2002. Hendrickson, RJ, Koniaris, LG, Jiang, S, Waldman, D, Massey, HT, and Sitzmann, JV. Purposeful delay in the repair of a traumatic left common carotid pseudoaneurysm in a bovine aortic arch presenting as a widened mediastinum. Journal of Trauma 53:1166-69, 2002. Sitzmann, JV and Koniaris, LG. Intra-arterial hepatic catheterization and pump placement. Operative Techniques in General Surgery 4:99- 110, 2002 Zimmers, TA, Davies, MV, Koniaris, LG, Haynes, P, Tomkinson, KN, McPherron, AC, Wolfman, NM, and Lee SJ. Cachexia induced by systemic myostatin administration in mice. Science 296:1486-88, 2002. 2003 Koniaris, LG. Induction of MIC-1/growth differentiation factor-15 following bile duct injury. Journal of Gastrointestinal Surgery 7:901-5, 2003. Koniaris, LG, Seibel, JA, Geschwind, JF, and Sitzmann, JV. Can ethanol therapies injure the bile ducts? Hepato-gastroenterology 50:69-72, 2003. Hendrickson, RJ, Diaz, AA, Salloum, R, and Koniaris, LG. Benign rectal ulcer: an underground cause of inpatient lower gastrointestinal bleeding. Surgical Endoscopy17:1759-65, 2003. Koniaris, LG, Schoeniger, LO, Kovach, S, and Sitzmann, JV. The quick, no-twist, no-kink portal confluence reconstruction. Journal of the American College of Surgeons 196:490-94, 2003. Schoeniger, LO, Bankey, P, Drugas, GT, and Koniaris, LG. Optimal closure of the complex abdomen. Archives of Surgery 138:458, 2003. Koniaris. LG, Drugas. G, Katzman. PJ, and Salloum, R. Management of gastrointestinal lymphoma. Journal of the American College of Surgeons 197:127-41, 2003. Koniaris, LG, Wilson, S, Drugas, G, and Simmons, W. Capnographic monitoring of ventilatory status during moderate (conscious) sedation. Surgical Endoscopy 17:1340, 2003. Koniaris, LG, McKillop, IH, Schwartz, SI, and Zimmers, TA. Liver regeneration. Journal of the American College of Surgeons 197:634-59, 2003. Zimmers, TA, McKillop, IH, Pierce, RH, Yoo, JY, and Koniaris, LG. Massive liver growth in mice induced by systemic interleukin 6 administration. Hepatology 38:326-34, 2003. Senn, JJ, Klover, PJ, Nowak, IA, Zimmers, TA, Koniaris, LG, Furlanetto, RW, and Mooney, RA. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. Journal of Biological Chemistry 278:13740-46, 2003. Klover, PJ, Zimmers, TA, Koniaris, LG, and Mooney, RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52:2784-89, 2003. THEODORE J. LAMPIDIS, PH.D. Professor of Cell Biology and Anatomy DESCRIPTION OF RESEARCH Dr. Lampidis’ research has evolved from his preliminary work on the physiology and pharmacology of cultured cardiac cells. A video/ electronic-computerized system was developed to monitor cardiac cell function in vitro. Using pulsating myocardial cells as a model, he focused on why the widely used anti-tumor agent, Adriamycin, affected the hearts of patients treated with this drug. This initial idea led Dr. Lampidis to study drug selectivity between certain types of tumor and normal cells and the chemical requirements 40 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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