SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M Dr. Shor-Posner is the principal investigator of the Fogarty International Center (FIC) AIDS and TB International Training and Research Program, funded by the NIH/FIC. The AIDS training curriculum is an international program designed to contribute to research capacity building in targeted developing countries, to facilitate the ability of scientists/clinicians to slow HIV-1 disease progression, prevent maternal-to-child transmission, and enhance survival. This program also seeks to provide training to qualified health professionals from two countries that are currently experiencing the most dramatic increases in TB and multi-drug resistant TB (MDR-TB) in the Americas, Honduras, and the Dominican Republic. Dr. Shor-Posner also is the mentor of Florida Department of Health-funded research titled, “Pulmonary Complications in Tobacco Users Infected With the Human Immunodeficiency Virus: Therapeutic Implications.” This proposal is for evaluation of the frequency of tobacco use among HIV+ individuals hospitalized at Jackson Memorial Hospital and the impact of tobacco use on the risk of developing lower respiratory infections. Additionally, Dr. Shor-Posner is the nutrition director of the NIH-funded General Clinical Research Center (GCRC). The GCRC, while located in several locations, functions as a single integrated department/unit with single program leadership and coordination. This clinical research infrastructure provides a conduit for the enhancement of multi-specialty projects. SELECTED PUBLICATIONS 2002 Miguez-Burbano, MJ, Pineda-Medina, L, Lecusay, R, Page, JB, Castillo, G, Burban, X, Rodriguez, A, Rodriguez, N, and Shor-Posner, G. Continued high risk behaviors in HIV infected drug abusers. Journal of Addictive Diseases 21:67-80, 2002. Shor-Posner, G , Miguez, MJ, Pineda, LM, Rodriguez, A, Ruiz, P, Castillo, G, Burban, X, Lecusay, R, and Baum, M. Impact of selenium status on the pathogenesis of mycobacterial disease in HIV-1-infected drug users during the era of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 29:169-73, 2002. Miguez-Burbano, MJ, Burbano, X, Rodriguez, A, Lecusay, R, Rodriguez, N, and Shor-Posner, G . Development of thrombocytosis in HIV+ drug users: impact of antiretroviral therapy. Platelets 13:183-85, 2002. Miguez, MJ, Burbano, X, Archer, H, and Shor-Posner, G . Limited impact of highly active antiretroviral therapy in thrombocytopenia. Journal of Acquired Immune Deficiency Syndromes 30:260-61, 2002. Miguez-Burbano, MJ, Navas, R, Forero, MG, Burbano, X, Rodriguez, N, and Shor-Posner, G . Evaluation of HIV prevention and counseling practices of obstetrician/gynecologists in Bogota, Colombia: impact on women’s knowledge and risk practices. AIDS Education and Prevention 14:72-80, 2002. Shor-Posner, G , Lecusay, R, Morales, G, Campa, A, and Miguez-Burbano, MJ. Neuroprotection in HIV-positive drug users: implications for antioxidant therapy. Journal of Acquired Immune Deficiency Syndromes 31 Supplement 2:S84-88, 2002. Burbano, X, Miguez-Burbano, MJ, McCollister, K, Zhang, G, Rodriguez, A, Ruiz, P, Lecusay, R, and Shor-Posner, G . Impact of a selenium chemoprevention clinical trial on hospital admissions of HIV-infected participants. HIV Clinical Trials 3:483-91, 2002. Shor-Posner, G , Lecusay, R, Miguez-Burbano, MJ, Morales, G, and Campa, A. Neuroprotection in HIV+ drug users: implications for antioxidant therapy. Journal of Acquired Immune Deficiency Syndromes 31:S84-S88, 2002. UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 29
C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M 2003 Miguez-Burbano, MJ, Archer, H, Rodriguez, M, and Shor-Posner, G . Discontinuation of secondary prophylaxis and the risk of Pneumocystis carinii pneumonia. AIDS 17:140-41, 2003. Shor-Posner, G , Lecusay, R, Miguez, MJ, Moreno-Black, G, Zhang, G, Rodriguez, N, Burbano, X, Baum, M, and Wilkie, F. Psychological burden in the era of HAART: impact of selenium therapy. International Journal of Psychiatry in Medicine 33:55-69, 2003. Miguez, MJ, Shor-Posner, G , Morales, G, Rodriguez, A, and Burbano, X. HIV treatment in drug abusers: impact of alcohol use. Addiction Biology 8:33-37, 2003. Miguez-Burbano, MJ, Burbano, X, Ashkin, D, Pitchenik, A, Allan, R, Pineda, L, Rodriguez, N, and Shor-Posner, G . Impact of tobacco use on the development of opportunistic respiratory infections in HIV seropositive patients on antiretroviral therapy. Addiction Biology 8:39-43, 2003. Perez-Then, E, Peña, R, Tavarez-Roja, M, Peña, C, Quiñonez, S, Buttler, M, Ammann, A, Hernandez, W, Goyanes, M, Miguez, MJ, Shor- Posner, G, and PMTCT Group. Preventing mother-to-child HIV transmission in a developing country: the Dominican Republic experience. Journal of Acquired Immune Deficiency Syndromes 34:506-11, 2003. LEO B. TWIGGS, M.D. Professor and Associate Dean of Women’s Health, Interim Chairman of Obstetrics and Gynecology, and Medical Director, Institute for Women’s Health DESCRIPTION OF RESEARCH Dr. Twiggs, who also is the Dean of Women’s Health at the University of Miami School of Medicine, has tested the efficacy of a vaccine for human papillomavirus (HPV) as a method of controlling the risk of cervical cancer. He also collaborates with Michael H. Antoni, Ph.D., and Mary Josephine O’Sullivan, M.D., to conduct studies of the effects of stressors and stress management on health behaviors and cervical neoplasia in women co-infected with HIV and HPV. SELECTED PUBLICATIONS 2002 Wright, TC Jr., Cox, JT, Massad, LS, Twiggs, LB, and Wilkinson, EJ. ASCCP-Sponsored Consensus Conference. 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. Journal of the American Medical Association 287:2120-29, 2002. 2003 Wright, TC Jr., Cox, JT, Massad, LS, Carlson, J, Twiggs, LB , and Wilkinson, EJ. American Society for Colposcopy and Cervical Pathology 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia. American Journal of Obstetrics and Gynecology 189:295-304, 2003. 30 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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G L O S S A R Y IFN—interferon IL
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SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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