SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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V I R A L O N C O L O G Y P R O G R A M SELECTED PUBLICATIONS 2002 Carastro, LM, Tan, CK, Selg, M, Jack, HM, So, AG, and Downey, KM. Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta. Nucleic Acids Research 30:2232-43, 2002. Meyer, PR, Matsuura, SE, Tolun, AA, Pfeifer, I, So, AG, Mellors, JW, and Scott, WA. Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial Agents and Chemotherapy 46:1540-5, 2002. Lu, X, Tan, CK, Zhou, JQ, You, M, Carastro, LM, Downey, KM, and So, AG. Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta. Journal of Biological Chemistry 277:24340-5, 2002. HIGHLIGHTS/DISCOVERIES • Demonstrated a direct interaction between the small subunit of human DNA polymerase delta (p50) and PCNA, a marker for cell proliferation, by reciprocal co-immunoprecipitation of the two proteins using antibodies against either p50 or PCNA, suggesting that this interaction is primarily responsible for processive DNA synthesis by DNA polymerase delta. Researchers in Dr. So’s laboratory have now confirmed that this interaction readily occurs in cells. This is important because the interaction of DNA polymerase delta with PCNA is at the core of replication machinery (replisome) function and crucial to our understanding of how DNA replication is coordinated with DNA repair and cell cycle progression. • Identified a novel 36-kDa protein, designated polymerase delta interacting protein 1 (PDIP1) that physically and functionally interacts with both PCNA and the 50-kDa subunit of DNA polymerase delta, both in vitro and in vivo. Researchers further have shown the expression of this protein is induced by tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6). These cytokines are essential for growth and proliferation of many cell types and implicated in the tumorigenesis of a number of cancers, including AIDS-related non-Hodgkin’s lymphoma and multiple myeloma. Thus, PDIP1 is a potential target for the development of novel therapeutic agents for the treatment of these tumors. UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 141
V I R A L O N C O L O G Y P R O G R A M 142 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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G L O S S A R Y IFN—interferon IL
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