SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M SELECTED PUBLICATIONS 2002 Antoni, MH, Cruess, DG, Klimas, N, Maher, K, Cruess, S, Kumar, M, Lutgendorf, S, Ironson, G, Schneiderman, N, and Fletcher, MA. Stress management and immune system reconstitution in symptomatic HIV-infected gay men over time: effects on transitional naive T cells (CD4(+)CD45RA(+)CD29(+)). American Journal of Psychiatry 159:143-45, 2002. 2003 Cruess, DG, Antoni, MH, Gonzalez, J, Fletcher, MA, Klimas, N, Duran, R, Ironson, G, and Schneiderman, N. Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy. Journal of Psychosomatic Research 54:185-89, 2003. Pereira, DB, Antoni, MH, Danielson, A, Simon, T, Efantis-Potter, J, Carver, CS, Duran, RE, Ironson, G, Klimas, N, Fletcher, MA, and O’Sullivan, MJ. Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus. Journal of Psychosomatic Research 54:237-44, 2003. Motivala, SJ, Hurwitz, BE, Llabre, MM, Klimas, NG, Fletcher, MA, Antoni, MH, LeBlanc, WG, and Schneiderman, N. Psychological distress is associated with decreased memory helper T-cell and B-cell counts in pre-AIDS HIV seropositive men and women but only in those with low viral load. Psychosomatic Medicine 65:627-35, 2003. O’Cleirigh, C, Ironson, G, Antoni, M, Fletcher, MA, McGuffey, L, Balbin, E, Schneiderman, N, and Solomon, G. Emotional expression and depth processing of trauma and their relation to long-term survival in patients with HIV/AIDS. Journal of Psychosomatic Research 54:225-35, 2003. HIGHLIGHTS/DISCOVERIES • Dr. Fletcher’s primary areas of focus include examining quantitative indices of lymphocyte subpopulations and qualitative indices of function including NKCC and IgG antibodies to latent herpes viruses, and how these respond to stressors and stress management interventions in these populations. • Her laboratory currently is exploring the mechanics of cytotoxicity (e.g., perforin and granzyme production) and how these relate to psychosocial factors via hypothalamic pituitary adrenal hormone changes. KENNETH W. GOODMAN, PH.D. Associate Professor of Medicine DESCRIPTION OF RESEARCH Work on ethics and evidence-based practice constitutes a natural extension of efforts to explore ethical issues in health informatics, epidemiology, and public health. The University of Miami’s reputation as a leader in under-addressed areas of clinical and research ethics continues to expand. The University continues to work on issues in the use of information technology, especially in public health. Moreover, the University’s ethics programs include international research ethics among the core foci, even as the University continues work on end-of-life care, environmental health and ethics, and genetics. Efforts to develop ethics curricula for scientists and others continue. Dr. Goodman is director of the University of Miami’s Bioethics Program, director of clinical and research ethics education at UM/Sylvester, and vice chair of UM/Sylvester’s Bioethics Committee. UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 15
C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M SELECTED PUBLICATIONS 2002 Green, RM, DeVries, KO, Bernstein, J, Goodman, KW, Kaufmann, R, Kiessling, AA, Levin, SR, Moss, SL, and Tauer, CA. Overseeing research on therapeutic cloning: a private ethics board responds to its critics. Hastings Center Report 32:27-33, 2002. 2003 Markovitz, BP and Goodman, KW. Case reports on the web redux: confidentiality still in jeopardy. Proceedings of the AMIA Annual Symposium 926, 2003. W. JARRARD GOODWIN, M.D., F.A.C.S. Professor of Otolaryngology DESCRIPTION OF RESEARCH Dr. Goodwin’s research focuses on the prevention and treatment of squamous cell carcinoma (SCCA) of the upper aerodigestive tract. Cancer Prevention and Control Dr. Goodwin has had a long-term interest in the potential of several micronutrients to inhibit the development of these cancers. Currently, various aspects of an extensive database from a phase III chemo-prevention trial, investigating the activity of beta-carotene, are being analyzed and published. He also is collaborating with investigators at the University of Florida on an NCI-funded oral cavity cancer control project. Disparities in mortality and stage at time of presentation for under-served populations is a developing interest. Quality of Life In addition, Dr. Goodwin studies the impact of treatment decisions on the quality of life experienced by patients with head and neck cancer. Current studies include collaborative investigations of speech and swallowing function following various treatment interventions. Working with Frank J. Penedo, Ph.D., he also is interested in the effect of stress and depression on survival and quality of life in this group of patients. Therapy Finally, Dr. Goodwin is actively involved in clinical trials studying the effect of P-53 gene therapy, alone and in combination with chemotherapy, for recurrent cancers of the oral cavity, pharynx, and larynx. SELECTED PUBLICATIONS 2003 Civantos, FJ, Gomez, C, Duque, C, Pedroso, F, Goodwin, WJ, Weed, DT, Arnold, D, and Moffat, F. Sentinel node biopsy in oral cavity cancer: correlation with PET scan and immunohistochemistry. Head & Neck 25:1-9, 2003. Franzmann, EJ, Schroeder, GL, Goodwin, WJ, Weed, DT, Fisher, P, and Lokeshwar, VB. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. International Journal of Cancer 106:438-45, 2003. HIGHLIGHTS/DISCOVERIES • Established, as one of the first investigators, the efficacy of selenium and retinoic acid in inhibiting carcinogenesis in an animal tumor model relevant to SCCA of the upper aerodigestive tract. • Published definitive outcomes studies analyzing the results of salvage treatment for recurrent cancer of the upper aerodigestive tract and for the treatment of Stage IV cancer. 16 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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