SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

C L I N I C A L O N C O L O G Y R E S E A R C H P R O G R A M
STEVEN E. LIPSHULTZ, M.D.
Professor and Chairman of Pediatrics
DESCRIPTION OF RESEARCH
Dr. Lipshultz’s research focuses on the prevention
of cardiomyopathy and heart failure
in children and young adults. He developed
the National Heart, Lung, and Blood Institute
(NHLBI)-sponsored Pediatric Cardiomyopathy
Registry (PCMR) to better understand genetic
and metabolic cardiomyopathies; the NHLBI
P2C2 HIV study to better understand infectious
and inflammatory cardiomyopathies; and the
NCI Dana-Farber Cancer Institute childhood
leukemia and NCI Children’s Oncology Group
childhood cancer survivor cohorts to better understand
toxic cardiomyopathies from
anthracycline chemotherapy and mediastinal irradiation.
Further understanding of clinical phenotypes,
human syndrome delineation,
epidemiology, and the natural history of these
pediatric diseases has resulted from these cohorts.
SELECTED PUBLICATIONS
2002
Lipshultz, SE, Lipsitz, SR, Sallan, SE, Simbre,
VC 2nd, Shaikh, SL, Mone, SM, Gelber, RD,
and Colan, SD. Long-term enalapril therapy for
left ventricular dysfunction in doxorubicintreated
survivors of childhood cancer. Journal of
Clinical Oncology 20:4517-22, 2002.
Harmon, WG, Dadlani, GH, Fisher, SD, and
Lipshultz, SE. Myocardial and pericardial disease
in HIV. Current Treatment Options in Cardiovascular
Medicine 4:497-509, 2002.
Lipshultz, SE, Giantris, AL, Lipsitz, SR, Kimball,
Dalton V, Asselin, BL, Barr, RD, Clavell, LA,
Hurwitz, CA, Moghrabi, A, Samson, Y, Schorin,
MA, Gelber, RD, Sallan, SE, and Colan, SD.
Doxorubicin administration by continuous infusion
is not cardioprotective: the Dana-Farber 91-
01 Acute Lymphoblastic Leukemia protocol.
Journal of Clinical Oncology 20:1677-82, 2002.
2003
Zareba, KM and Lipshultz, SE . Cardiovascular
complications in patients with HIV infection.
Current Infectious Disease Reports 5:513-20,
2003.
Constine, LS, Hinkle, AS, French, CA,
Kozlowski, AM, Proukou, C, Lipsitz, SR, Miller,
TL, Vermilion, RP, Rifai, N, and Lipshultz, SE.
Radiation-associated risk factors for premature
cardiovascular disease in childhood cancer survivors
include accelerated atherosclerosis. International
Journal of Radiation Oncology Biology
Physics 57(2 Supplement):S199-200, 2003.
Adams, MJ, Lipshultz, SE, Schwartz, C, Fajardo,
LF, Coen, V, and Constine, LS. Radiation-associated
cardiovascular disease: manifestations and
management. Seminars in Radiation Oncology
13:346-56, 2003.
Lipshultz, SE, Fisher, SD, Lai, WW, and Miller,
TL. Cardiovascular risk factors, monitoring, and
therapy for HIV-infected patients. AIDS 17
Supplement 1:S96-122, 2003.
Fisher, SD, Bowles, NE, Towbin, JA, and
Lipshultz, SE. Mediators in HIV-associated cardiovascular
disease: a focus on cytokines and
genes. AIDS 17 Supplement 1:S29-35, 2003.
Lipshultz, SE, Somers, MJ, Lipsitz, SR, Colan,
SD, Jabs, K, and Rifai, N. Serum cardiac troponin
and subclinical cardiac status in pediatric
chronic renal failure. Pediatrics 112:79-86, 2003.
Al-Attar, I, Orav, EJ, Exil, V, Vlach, SA, and
Lipshultz, SE. Predictors of cardiac morbidity
and related mortality in children with acquired
immunodeficiency syndrome. Journal of the
American College of Cardiology 41(9):1598-605,
2003.
Benun, J, Fisher, SD, Orav, EJ, Schwartz, ML,
Exil, V, Messere, C, and Lipshultz, SE . Cardiac
management by pediatricians versus pediatric cardiologists
in an inpatient academic center. American
Heart Journal 145:424-9, 2003.
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UM/Sylvester Comprehensive Cancer Center Scientific Report 2004