SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M Dr. Lee also has developed an interest in the identification of cancer risk factors in adults. For example, he recently co-authored a paper examining cancer mortality risk in pesticide applicators. He served as the dissertation chair for a project examining cancer risk in Florida firefighters. Two papers examining cancer mortality and cancer incidence in this occupational group are presently under peer review. In 2003, Dr. Lee and his colleagues published a lead article in the journal Ophthalmology examining the association between glaucoma and cause-specific mortality including cancer. Dr. Lee’s most recent tobacco-related publication focused on trends in smoking rates among 209 of the largest worker groups in the United States. This paper was published in the Journal of Occupational and Environmental Medicine in 2004. A novel non-nicotine replacement therapy smoking cessation strategy for older adults with chronic disease, including cancer patients, is presently under review by the NCI. A cognitive behavioral smoking cessation program directed at military recruits prior to entry into basic training is also under review at the Department of Defense. SELECTED PUBLICATIONS 2002 Lee, DJ, Gomez-Marin, O, Lam, BL, and Zheng, DD. Visual acuity impairment and mortality in U.S. adults. Archives of Ophthalmology 120:1544-50, 2002. Lee, DJ, Trapido, E, and Rodriguez, R. Self-reported school difficulties and tobacco use among fourth- to seventh-grade students. Journal of School Health 72:368-73, 2002. 2003 Fleming, LE, Gomez-Marin, O, Zheng, D, Ma, F, and Lee, DJ. National Health Interview Survey mortality among U.S. farmers and pesticide applicators. American Journal of Industrial Medicine 43:227-33, 2003. Lee, DJ, Gomez-Marin, O, Ma, F, and Lam, BL. Uncorrected binocular distance visual acuity impairment and survival: The National Health and Nutrition Examination Survey I. Ethnicity and Disease 13:485-91, 2003. Lee, DJ, Trapido, E, and Rodriguez, R. Secondhand smoke and earaches in adolescents: The Florida Youth Cohort Study. Nicotine and Tobacco Research 5:1-4, 2003. HIGHLIGHTS/DISCOVERIES • Demonstrated an association between exposure to second-hand smoke and self-reported earaches in adolescents, which is novel in that these associations have typically been reported in younger children and infants. The two FAMRI-funded studies will help to determine if biologically confirmed exposure to second-hand smoke is related to both reported earaches and clinically confirmed indicators of middle ear problems. SILVINA LEVIS-DUSSEAU, M.D. Professor of Medicine DESCRIPTION OF RESEARCH For the last ten years, Dr. Levis-Dusseau, director of the Osteoporosis Center, a joint venture between the University of Miami School of Medicine and the Miami Veterans Administration Medical Center, has been conducting clinical trials testing the effectiveness of different drugs in the treatment of osteoporosis. Currently, she is conducting an NIH-sponsored trial that will evaluate the effectiveness of estrogens derived from soy in preventing menopausal symptoms and bone loss. Her research interests also include improving muscle function and bone mass in elderly individuals with vitamin D deficiency. Dr. Levis-Dusseau has collaborated with Bernard A. Roos, M.D., Michael H. Antoni, Ph.D., and Neil Schneiderman, Ph.D., for the past three UM/Sylvester Comprehensive Cancer Center Scientific Report 2004 23
C A N C E R P R E V E N T I O N A N D C O N T R O L P R O G R A M years to conduct a clinical trial testing the effects of low-dose estrogen treatment on quality of life, osteoporosis risk, and other physical indicators in men who had undergone androgen deprivation therapy for metastatic prostate cancer. This project is funded by the NCI as part of the Center for Psycho-Oncology Research (CPOR), which is directed by Michael H. Antoni, Ph.D. SELECTED PUBLICATIONS 2002 Levis, S, Quandt, SA, Thompson, D, Scott, J, Schneider, DL, Ross, PD, Black, D, Suryawanshi, S, Hochberg, M, and Yates, J. Alendronate reduces the risk of multiple symptomatic fractures: results from the fracture intervention trial. Journal of the American Geriatric Society 50:409-15, 2002. 2003 Hernandez-Cassis, C, Vogel, CK, Hernandez, TP, Econs, MJ, Iglesias, M, Iglesias, A, Levis, S, Roos, BA, Howard, GA, and Gamarra, AI. Autosomal dominant hyperostosis/osteosclerosis with high serum alkaline phosphatase activity. Journal of Clinical Endocrinology & Metabolism 88:2650-55, 2003. HIGHLIGHTS/DISCOVERIES • Discovered that vitamin D deficiency in South Florida residents is higher than expected: approximately 25 percent in young adults and 30 percent in the elderly. FRANK J. PENEDO, PH.D. Assistant Professor of Psychology Psycho-Oncology, Psychology of Aging and Immunosenescence in Chronically Ill Older Adults Within the fields of health psychology and behavioral medicine, cancer and the human immunodeficiency virus (HIV) have provided unique opportunities to evaluate the role of psychosocial factors in disease acquisition and progression among various populations. Part of Dr. Penedo’s research is examining the role of psychosocial factors such as stress, coping, and personality style in psychological distress and physical health status in three specific populations: 1) HIV+ ethnically diverse men who have sex with men (MSM) and heterosexual older men with a history of substance use, 2) men treated with radical prostatectomy or radiation for localized prostate cancer, and 3) men and women diagnosed with Stages I- III of head and neck cancer. Dr. Penedo’s research with these chronic disease groups is focused primarily on evaluating the efficacy of group- and individual-based stress management interventions on reducing distress and improving quality of life (QOL) and physical health status among older cancer or HIV populations (50 years and older). Dr. Penedo is particularly interested in how psychosocial factors such as stress, coping, and personality style may interact with health behaviors (e.g., treatment adherence), neuroendocrine function, and the agerelated decrements in immune function (i.e., immuno-senescence) seen in older populations. More specifically, he is interested in how stress and other psychosocial factors may interact with, and exacerbate, age-related decrements in immune function on the one hand, and disease progression in older cancer and HIV populations on the other. Several of the research questions involved in Dr. Penedo’s work aim to answer: 1) whether psychosocial factors impact neuroendocrine and immune parameters in chronically ill older adults (e.g., Does psychological stress-related activation 24 UM/Sylvester Comprehensive Cancer Center Scientific Report 2004
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G L O S S A R Y IFN—interferon IL
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SCIENTIFIC REPORT 2004 - Sylvester Comprehensive Cancer Center

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