9th Annual International Meeting For Autism Research ... - Confex

Program
5:30 126.008
Whole Genome Brain Gene Expression in Autism Reveals
Signatures of Multiple Ongoing Processes. M. L. Chow* 1 , H. R. Li 1 ,
J. B. Fan 2 , C. April 2 , M. E. Winn 3 , A. Wynshaw-Boris 4 , N. Schork 3 , X.
D. Fu 1 and E. Courchesne 1 , (1)University of California San Diego,
(2)Illumina, Inc., (3)Scripps Genomic Medicine & The Scripps
Translational Sciences Institute (STSI), (4)UCSF School of Medicine
Scientific Panels
127 Preschool Autism Communication Trial
(PACT)
4:45 PM - 5:45 PM - Grand Ballroom E Level 5
Organizer: J. Green; The University of Manchester
PACT is the first large scale RCT to be completed
to date on psychosocial intervention for autism. This
panel provides a timely overview for the field of the rich
clinical dataset and scientific material generated by this
large trial. In addition to answering primary questions of
treatment effectiveness, PACT was also designed as a
developmental experiment, testing key aspects of early
psychopathology of autism through innovative analysis
of mediation. The presentations focus on primary ITT
analysis of the trial and implications for current autism
intervention practice and research; investigations
of causal relationships between parent-child dyadic
communication and autism development; and the value
of patient-nominated outcome measures. We present
a new quality of life family measure developed and
validated during the PACT trial.
4:45 127.001
Parent-Mediated Communication-Focused Treatment for Preschool
Children with Autism (MRC PACT); A Randomised Controlled
Trial. J. Green* 1 , T. Charman 2 , H. McConachie 3 , C. R. Aldred 4 , V.
Slonims 5 , P. Howlin 6 , A. Le Couteur 7 , K. Leadbitter 4 , K. Hudry 8 , S.
Byford 9 , B. Barrett 9 , K. Temple 10 , W. MacDonald 1 , A. Pickles 4 and T.
PACT Consortium 4 , (1)The University of Manchester, (2)Institute of
Education, University of London, (3)The University of Newcastle,
(4)University of Manchester, (5)Guy’s and St. Thomas’ NHS Trust,
(6)Institute of Psychiatry, King’s College London, (7)Newcastle
University, (8)Department of Psychology and Human Development,
Institute of Education, (9)Institute of Psychiatry, (10)University of
Newcastle
5:10 127.002
Analysing the Impact of Parent Communication Training On the
Child with Autism: Learning From Trials. A. Pickles* 1 , J. Green 2 , H.
McConachie 3 , T. Charman 4 , C. R. Aldred 1 and T. PACT Consortium 1 ,
(1)University of Manchester, (2)The University of Manchester,
(3)The University of Newcastle, (4)Institute of Education, University
of London
5:30 127.003
The Family Life Questionnaire: The Development of An Autism-
Specifi c Measure of Family Life Functioning. D. Kapadia* 1 , K.
Leadbitter 2 , W. MacDonald 1 , R. Emsley 1 , H. McConachie 3 , J.
Green 1 and T. PACT Consortium 2 , (1)The University of Manchester,
(2)University of Manchester, (3)The University of Newcastle
Scientific Panels
128 The Role of the Corpus Callosum in Autism
4:45 PM - 5:45 PM - Grand Ballroom AB Level 5
Moderator: E. Marco; UC San Francisco
Organizer: E. Sherr; UCSF
The corpus callosum is the brain’s major cortical white
matter tract with nearly 200 million axons connecting
the right and left cerebral hemispheres. Emerging
evidence suggests that individuals with ASD have small
or anatomically atypical corpus callosa. Furthermore,
individuals with congenital absence of the corpus
callosum (AgCC) can have communication, executive
function and social disabilities that are within the autism
spectrum. Both groups experience sensory sensitivities
that may play a role in learning and behavioral
difficulties. In this session, we show that AgCC
individuals have profound social deficits associated
with decreased sensory processing. Moreover, AgCC
participants have deficits in recognition of facial
emotion that appears related to not looking at the eyes
and the mouth, as found in ASD generally. We also
provide important insights from MEG-based functional
connectivity: resting state connectivity is decreased in
frontal lobe regions and correlates with both executive
function and overall social cognition performance.
These findings underscore the role that disrupted longrange
connectivity plays in autism.
4:45 128.001
Agenesis of the Corpus Callosum and the Autism Spectrum. Y.
Lau* 1 , E. Marco 2 , L. B. N. Hinkley 1 , Z. Strominger 1 , R. Jeremy 1 , P.
Mukherjee 1 , S. Nagarajan 1 and E. Sherr 3 , (1)University of California,
San Francisco, (2)UC San Francisco, (3)UCSF
5:00 128.002
Facial Emotion Recognition in Primary Agenesis of the Corpus
Callosum. L. K. Paul* 1 , M. W. Bridgman 1 , W. S. Brown 2 , M. L.
Spezio 1 and R. Adolphs 1 , (1)Caltech, (2)Fuller Graduate School of
Psychology
5:15 128.003
Individuals with Agenesis of the Corpus Callosum Show Atypical
Sensory Processing. M. Arroyo* 1 , Z. Strominger 1 , W. Dunn 2 , R.
Jeremy 1 , A. J. Barkovich 1 , E. Sherr 3 and E. Marco 4 , (1)University of
California, San Francisco, (2)University of Kansas, (3)UCSF, (4)UC
San Francisco
5:30 128.004
Functional Connectivity and Executive Function in Agenesis of
the Corpus Callosum. L. B. N. Hinkley* 1 , E. Marco 2 , A. M. Findlay 1 ,
R. Jeremy 1 , Z. Strominger 1 , M. Wakahiro 1 , P. Mukherjee 1 , S.
Nagarajan 1 and E. Sherr 3 , (1)University of California, San Francisco,
(2)UC San Francisco, (3)UCSF
FrIday –PM
9th Annual International Meeting For Autism Research (IMFAR) 2010 47