9th Annual International Meeting For Autism Research ... - Confex

Program
12:00-1:00P Business Meeting (Grand Ballroom F Lvl 5)
1:15-3:15P IES: The Relationship between Epilepsy and Autism (Grand Ballroom F Lvl 5)
1:15-3:15P
Oral Session: Developmental Stages, Imitation and Play
(Grand Ballroom E Lvl 5)
Saturday May 22 nd
Oral Session: Treatment 2 (Grand Ballroom AB Lvl 5)
Oral Session: Clinical Phenotype 2 (Grand Ballroom CD
Lvl 5)
Invited Educational Symposium
137 Relationship Between Epilepsy and Autism
1:15 PM - 3:15 PM - Grand Ballroom F Level 5
Oral Sessions
138 Clinical Phenotype 2
1:15 PM - 3:15 PM - Grand Ballroom E Level 5
Moderator: S. Spence; NIH
This symposium is designed to explore the relationship
between epilepsy and ASD. While higher rates of
epilepsy have long been reported in ASD, prevalence
estimates vary from 5% to as much as 46%. While
variation likely reflects differences in study samples,
several factors appear to truly increase epilepsy risk
such as lower IQ, co-morbid syndromes (e.g. nonidiopathic
autism) and gender. However, the rate
of epilepsy in idiopathic ASD with normal IQ is still
significantly above population risk, suggesting autism
itself is associated with an increased epilepsy risk. The
recent appreciation that epileptiform EEG abnormalities
occur with rates as high as 60%, even in the absence
of epilepsy, has lead investigators to propose they
may play a causal role. We posit that epilepsy and
epileptiform EEGs represent biomarkers of cortical
dysfunction in ASD and believe relationships should be
vigorously explored. This symposium will review clinical
and electrophysiological data and describe the breadth
of association with ASD. Next we will describe a genetic
disease model known to overlap with ASD and epilepsy:
Tuberous Sclerosis Complex (TSC), whose pathways
provide researchers a window into this relationship as
well as novel therapeutic targets. Finally, we discuss
pathophysiological data that characterizes ASD as an
imbalance between neuronal excitation and inhibition,
which in turn suggests possible directions for future
research.
1:15 137.001
EPILEPSY, EPILEPTIFORM EEG AND AUTISM: Who has it and what
might it mean?. M. Chez*, Sutter Neuroscience Institute
1:45 137.002
Magnetoencephalography in ASD: How can new
electrophysiological imaging techniques help explore the
relationship?. J. D. Lewine*, Alexian Brothers Medical Center
2:15 137.003
Tuberous Sclerosis Complex: What can the knowledge of signaling
pathway abnormalities teach us about ASD?. M. Sahin*, Director of
Multi-disciplinary Tuberous Sclerosis Program
2:45 137.004
Excitatation/Inhibition Imbalance in ASD: Is this a
pathophysiological model of cerebral dysfunction in ASD?. T.
Hensch*, Center for Brain Science, Harvard University
1:15 138.001
Pragmatic Language and Social Cognitive Overlap in Children with
Autism and Fragile X Syndrome. G. E. Martin*, M. Losh, J. Klusek
and A. Harris, University of North Carolina at Chapel Hill
1:30 138.002
Clinical and Neuropsychological Overlap in the Broad Autism
Phenotype and the FMR1 Premutation. M. Losh*, G. E. Martin and
J. Klusek, University of North Carolina at Chapel Hill
1:45 138.003
Variants in the Social-Emotional Phenotype of Children with Autism
and Children with Fragile X Syndrome. N. M. Russo*, E. Berry-
Kravis, C. McKown and M. Lipton, Rush University Medical Center
2:00 138.004
A Comparison of Sleep Patterns and Behaviour in Children with
Autism, Other Developmental Disabilities, and Typically Developing
Children. A. L. Richdale* 1 and S. Cotton 2 , (1)La Trobe University,
(2)University of Melbourne
2:15 138.005
Effects of Social and Non-Social Cues On Saccadic Eye Movements
in ASD and ADHD. B. Azadi* 1 , U. Ettinger 2 , P. Asherson 3 , K. L.
Ashwood 1 , S. Cartwright 1 , G. Childs 1 and P. Bolton 1 , (1)Institute of
Psychiatry, King’s College London, (2)Department of Psychiatry,
Ludwig-Maximilians-University Munich, (3)Institute of Psychiatry
2:30 138.006
Personal Space and Interpersonal Distance in Autism: Insights
From the SRS. D. P. Kennedy* 1 , J. N. Constantino 2 and R. Adolphs 1 ,
(1)Caltech, (2)Washington University School of Medicine
2:45 138.007
Sex Differences in Autistic Traits: Is High Verbal IQ Protective
against Social Impairments in Girls but Not Boys?. K. Dworzynski* 1 ,
A. Ronald 2 , R. A. Hoekstra 3 , F. Rijsdijk 1 and F. Happé 1 , (1)Institute of
Psychiatry, King’s College London, (2)Birkbeck College, University
of London, (3)University of Cambridge
3:00 138.008
Head Circumference Developmental Course in the First 14 Months
of Life in Children with ASD. A. Narzisi*, T. Filippi, F. Apicella, E.
Santocchi, S. Calderoni, S. Calugi, R. Tancredi and F. Muratori,
University of Pisa – Stella Maris Scientifi c Institute
9th Annual International Meeting For Autism Research (IMFAR) 2010 65
Saturday – PM