6th International Workshop on Breast Densitometry and Breast ...

More documents

Recommendations

Info

6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment BENIGN BREAST DISEASE, MAMMOGRAPHIC BREAST DENSITY AND THE RISK OF BREAST CANCER Jeffrey A. Tice, MD; Ellen S. O’Meara, PhD; Donald L. Weaver, MD; Celine Vachon, PhD; Rachel Ballard-Barbash, MD, MPH; Karla Kerlikowske, MD ABSTRACTS FOR SPEAKERS Division of General Internal Medicine, Department of Medicine; General Internal Medicine Section, Department of Veteran Affairs and Departments of Medicine and Epidemiology and Biostatistics (Drs. Kerlikowske); University of California, San Francisco, San Francisco, CA. Group Health Research Institute (Dr. O’Meara); Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center (Dr. Weaver). Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute (Dr. Ballard-Barbash). Background: Benign breast disease and high breast density are prevalent, strong risk factors for breast cancer. Women with both risk factors may be at very high risk. Methods: We included 42,818 women participating in the Breast Cancer Surveillance Consortium (BCSC) from 1994 through 2009 who had no prior diagnosis of breast cancer and had undergone at least one benign breast biopsy and mammogram; 1,359 women developed incident breast cancer in 6.1 years of follow-up (78% invasive, 22% DCIS). Community radiologists rated breast density using Breast Imaging Reporting and Data System categories: almost entirely fat (low density); scattered fibroglandular densities (average density); heterogeneously dense (high density); extremely dense (very high density). Results: In Cox regression models, benign breast disease and breast density were independently associated with breast cancer. Atypical hyperplasia and very high density was uncommon (0.6% of biopsies), but associated with the highest risk [hazard ratio (HR); 5.3, 95% confidence interval (CI) 3.5- 8.1] compared to non-proliferative changes and average density. Proliferative disease without atypia (26% of biopsies) was associated with elevated risk that varied little across levels of density: average (HR 1.4, 95% CI 1.1-1.7), high (HR 2.0, 95% CI 1.7-2.4), or very high (HR 2.0, 95% CI 1.5-2.7). Low breast density (4.5% of biopsies) was associated with low risk (HRs
6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry DETERMINANTS OF BREAST TISSUE COMPOSITION IN 15-18 YEAR OLD GIRLS and Breast Cancer Risk Assessment Norman F. Boyd*, Ella Huszti, Greg Stanisz, Sofia Chavez, Qing Li, Linda Linton, Monica Taylor, Sara Hennessy, Lisa J. Martin, Salomon Minkin Campbell Institute for Breast Cancer Research Ontario Cancer Institute Background. Breast tissue is especially susceptible to carcinogenic influences in early life and several variables in early life, including birth weight, growth in adolescence and attained height, influence risk of breast cancer in later life. We examine here the association of these risk factors in early life with variations in breast tissue composition in 15-18 year old girls. Methods. We recruited 437 girls aged 15-18, and used magnetic resonance scans to measure the water and fat content of the breast. All scans were obtained in the follicular phase of the menstrual cycle. We also made anthropometric measurements. We obtained from mothers by questionnaire a history of their daughter’s birth weight, breast-feeding and growth during childhood, and of maternal health during pregnancy with the daughter. Results. At ages 15-18 years, percent water in the breast was positively associated with: greater birth weight (adjusted for age and duration of breast feeding; p=0.06); longer duration of breast-feeding (adjusted for age and birth weight; p=0.02); and greater increase in height between ages 9 and 12 years (adjusted for age, weight and relative height at age 9; p=0.0007). Growth between ages 12 and 15 (adjusted for age, weight and relative height at age 12; p=0.6) was not associated with percent breast water at ages 15-18. Greater birth weight (p
Page 1: 6 th International
Page 4 and 5: 6 th International
Page 6 and 7: PROGRAM 6 th International<
Page 8 and 9: BREAST DENSITY - WHAT IS A WOMAN TO
Page 10 and 11: ABSTRACTS FOR SPEAKERS 6 th <strong
Page 32 and 33: P1 6 th International</stro
Page 44 and 45: P10 6 th International</str
Page 72 and 73:
P35 6 th International</str
Page 74 and 75:
Page 76 and 77:
6 th International
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
6 th International
Page 88 and 89:
6 th International
Page 90 and 91:
88 6 th International</stro
Page 92 and 93:
6 th International
Page 94 and 95:
6 th International
Page 96 and 97:
6 th International
Page 98:
6 th International
show all

6th International Workshop on Breast Densitometry and Breast ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?