6th International Workshop on Breast Densitometry and Breast ...

More documents

Recommendations

Info

P21 6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment MAMMOGRAPHIC DENSITY PHENOTYPES AND RISK OF BREAST CANCER: A META-ANALYSIS Andreas Pettersson 1 , Rebecca E. Graff 1 , Laura Baglietto 2, 3 , Marije F. Bakker 4 , Norman Boyd 5 , KeeSeng Chia 6 , Kamila Czene 7 , Isabel dos Santos Silva 8 , Louise Eriksson 7 , Graham G. Giles 2, 3, 9 , Per Hall 7 , Mikael Hartman 6, 7, 9 , John L. Hopper 3 , Kavitha Krishnan 2, 3 , Jingmei Li 11 , Qing Li 5 , Gertraud Maskarinec 12 , Valerie McCormack 13 , Ian Pagano 12 , Bernard A. Rosner 14, 15 , Christopher Scott 16 , Jennifer Stone 3 , Giske Ursin 17, 18 , Celine Vachon 16 , Carla H. van Gils 4 , Chia Siong Wong 6 1, 14 , Rulla M. Tamimi 1) Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; 2) Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; 3) Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, The University of Melbourne, Australia; 4) Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands; 5) Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada; 6) Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore; 7) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 8) Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; 9) Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; 10) Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 11) Human Genetics Division, Genome Institute of Singapore, Singapore; 12) Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA; 13) Section of Environment and Radiation, <strong>International</strong> Agency for Research on Cancer, Lyon, France; 14) Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 15) Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA; 16) Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA; 17) Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; 18) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Background: Fibroglandular breast tissue appears dense on mammogram; fat appears nondense. We investigated whether absolute or percent dense area more strongly predicts breast cancer risk, and whether absolute nondense area is independently associated with risk. Methods: We conducted a meta-analysis of 13 case-control studies, each having provided parameter estimates and standard errors from logistic regressions for associations between one standard deviation (SD) increments in mammographic density phenotypes and breast cancer risk. We used random-effects models to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). ABSTRACTS Results: Among premenopausal women (1,776 cases; 2,834 controls), summary ORs for one SD increments were 1.37 (95% CI: 1.29-1.47) for absolute dense area, 0.78 (95% CI: 0.71-0.86) for absolute nondense area, and 1.52 (95% CI: 1.39-1.66) for percent dense area when pooling estimates adjusted for age, BMI and parity. Corresponding ORs among postmenopausal women (6,643 cases; 11,187 controls) were 1.38 (95% CI: 1.31-1.44), 0.79 (95% CI: 0.73-0.85), and 1.53 (95% CI: 1.44-1.64). After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary ORs became 0.82 (95% CI: 0.71-0.94; P- heterogeneity: 0.02) for premenopausal and 0.85 (95% CI: 0.75-0.96; P-heterogeneity:
6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment P22 MAMMOGRAPHIC DENSITY AND EARLY MAMMOGRAPHIC SCREENING PERFORMANCE MEASURES IN THE NORWEGIAN BREAST CANCER SCREENING PROGRAM Solveig Hofvind 1,2* Isabel dos-Santos-Silva 3 , Merete Ellingjord-Dale 4 , Sofie Sebuødegård 1 , Giske Ursin 1,5 1 Cancer Registry of Norway, Oslo, Norway; 3 Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK ; 4 Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway ; 2 Oslo and Akershus University College of Applied Sciences, Oslo, Norway; 5 University of Southern California, Los Angeles, CA ABSTRACTS Background: It is well known that mammographic density (MD) increases the risk of breast cancer and reduces sensitivity of mammographic screening. However, less is known on how MD may affect early performance measures in mammographic screening among those recalled for further assessments. We used data collected by the population-based Norwegian Breast Cancer Screening Program (NBCSP) to investigate associations of MD and the percentage of cancers detected among women recalled for further assessment (positive predictive value one, PPV-1), as well as percentage of cancers detected among the women who underwent a biopsy (fine needle aspiration cytology or core needle biopsy)(PPV-2) and MD associations with prognostic histopathological tumor characteristics. Methods: We analyzed data from women screened in the NBCSP during 1996-2010 who were subsequently recalled for further assessments. Visual assessment of MD was routinely performed on analogue (80%) or digital mammograms by radiologists with expertise in mammography using an inhouse visual 3-category scale (low: MD
Page 1:
6 th International
Page 4 and 5:
6 th International
Page 6 and 7: PROGRAM 6 th International<
Page 8 and 9: BREAST DENSITY - WHAT IS A WOMAN TO
Page 10 and 11: ABSTRACTS FOR SPEAKERS 6 th <strong
Page 12 and 13: 6 th International
Page 32 and 33: P1 6 th International</stro
Page 44 and 45: P10 6 th International</str
Page 90 and 91: 88 6 th International</stro
Page 98: 6 th International
show all

6th International Workshop on Breast Densitometry and Breast ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?