6th International Workshop on Breast Densitometry and Breast ...

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6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment P23 CHILDHOOD AND ADOLESCENT GROWTH PREDICTS MAMMOGRAPHIC DENSITY MEASURES ASSOCIATED WITH BREAST CANCER RISK IN MID-LIFE: A PROSPECTIVE STUDY John L. Hopper 1 , Jennifer Stone 1 , Carmel Apicella 1 , Linh T. Nguyen 1 , Quang M. Bui 1 , Gillian S. Dite 1 , Daniel F. Schmidt 1 , Enes Makalic 1 , Melanie C Matheson 1 , Shyamali Dharmage 1 , Graham G. Giles 2 1 Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Carlton VIC 3053, Australia; 2 Cancer Epidemiology Centre, Cancer Council Victoria, Carlton VIC 3053, Australia Background: Mammographic density (MD) adjusted for age and body mass index (BMI) is associated with breast cancer risk. We conducted a prospective study to determine if growth in childhood and adolescence predicts risk-associated MD. Methods: In 1968, the Tasmanian Asthma Study measured height and weight for almost all school children born in 1961. We obtained measured heights and weights for this cohort from annual school records for 1969 to 1977. Between 2009 and 2010, for 215 of these women we administered a questionnaire, including height and weight, and digitised at least one mammogram. Absolute and percent MD were measured using the computer-assisted method Cumulus. Preece-Baines growth curves were fitted and missing data imputed under a multivariate normal model. We used linear regression to assess the association between square root MD and covariates. Results: Both absolute and percent MD adjusted for age and current BMI were negatively associated with log BMI at each of ages 7 to 15, and positively associated with age at menarche. When fitted together, log BMI at age 15 remained negatively associated (p < 0.00001), explaining about 15% of the variance (cf.
P24 6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment BACKGROUND PARENCHYMAL UPTAKE OF Tc-99m SESTAMIBI ON MOLECULAR BREAST IMAGING IN WOMEN WITH DENSE BREASTS Hruska CB 1 , Conners AL 1 , Jones KN 1 , Lingineni R 2 , Carter R 2 , Shah S 3 , Visscher D 3 , Rhodes DJ 4 , Vachon C 2 1 Departments of Radiology, 2 Health Sciences Research, 3 Laboratory Medicine and 4 Pathology, and Medicine, Mayo Clinic, Rochester, MN Background: While evaluating molecular breast imaging (MBI) for adjunct screening in women with dense breasts, various presentations of background parenchymal uptake (BPU), or uptake of Tc-99m sestamibi in normal fibroglandular tissue (FT), were observed. We describe the prevalence of BPU in dense breasts and examine clinical and histologic risk factors associated with BPU. ABSTRACTS Methods: Screening MBI exams performed between April 2010 and March 2012 at Mayo Clinic in women with dense breasts (BI-RADS D2 - scattered densities; D3 - heterogeneously dense, or D4 - extremely dense) were reviewed. Participants with breast implants or cancer diagnosed at screening were excluded. BPU intensity was subjectively categorized by two radiologists as photopenic (uptake in FT < subcutaneous fat), mild (uptake in FT = fat), moderate (uptake in FT up to 2x fat), or marked (uptake in FT > 2x fat). Association of BPU with age, BI-RADS mammographic density, percent density measured by Cumulus, menopausal status, and use of hormonal medications was examined using Kruskal-Wallis and Chi-Square analyses. To examine association of histological factors with BPU, prospective coreneedle breast biopsy of 23 postmenopausal women was performed in regions of mammographically dense tissue demonstrating either photopenic (18 women) or marked (5 women) BPU. Results: In 1274 MBI exams, BPU was photopenic in 273 (21%), mild in 826 (65%), and moderate or marked in 175 (14%). Significant differences in distribution of BPU were observed with age, BI-RADS density, percent density, menopausal status, and postmenopausal hormone use (all p75% involuted). Conclusion: Moderate/marked BPU occurred more often in denser breasts and in women who were younger, pre- or perimenopausal, or using exogenous hormones. In each density category, substantial proportions of both moderate/marked and photopenic BPU were observed, establishing that similarappearing FT on mammography can demonstrate considerable differences in BPU on MBI. 57
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