6th International Workshop on Breast Densitometry and Breast ...

More documents

Recommendations

Info

P13 6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment RISK ASSOCIATION OF SUBREGIONAL MEASUREMENTS OF BREAST DENSITY Duewer, Fred 1 , Fan, Bo 1 , Karla, Kerlikowske 2,3 , Ma, Lin 2,3 , Malkov, Serghei 1 , and Shepherd, John 1 University of California, San Francisco, Department of Radiology 1 , Department of Epidemiology and Biostatistics 2 , and Department of Medicine 3 Although breast density is, excepting age, the strongest known risk factor for breast cancer, little is known about the spatial variation in breast density. Our hypothesis is that the association of local fibroglandular volume with breast cancer in a given subregion of the breast varies based on the position of that subregion relative to the nipple and breast outline. We used single x-ray absorptiometry to obtain pixel-by-pixel maps of breast density and spatially normalized each breast density map using estimated midplane position and the breast outline on casecontrol data set consisting of 278 cases and 834 controls matched by age and body mass index. We measured the absolute fibroglandular volume in 100 subregions for each image. We compared average fibroglandular volume in subregions and the absolute left-right difference in each subregion (asymmetry) depending on case-control status. We found that average fibroglandular volume was higher in cases than controls for all subregions and that left-right fibroglandular volume asymmetry was also higher for cases than for controls. We tested for regional differences in breast cancer risk association between cases and controls and according to age and body mass index by measuring the P-value of the t-test between cases and controls for each subregion. We found that subregions closer to the nipple differed more significantly between cases and controls. In addition, we used principal component analysis on the average fibroglandular volume in the 100 subregions and identified three principal components that contributed significantly to breast cancer risk (P
6 th <strong>International</strong> <strong>Workshop</strong> on Breast Densitometry and Breast Cancer Risk Assessment P14 THE ASSOCIATION BETWEEN VITAMIN D INTAKE, SEASON AND MAMMOGRAPHIC DENSITY IN NORWEGIAN POSTMENOPAUSAL WOMEN Merete Ellingjord-Dale¹, Isabel dos Santos Silva ² , Tom Grotmol³, Solveig Hofvind³, Lene Frost Andersen¹, Samera Azeem Qureshi¹, Marianne Skov Markussen¹, Elisabeth Couto⁵, Giske Ursin 1,3,4 1 University of Oslo, Norway, 2 London School of Hygiene and Tropical Medicine, UK , 3 Cancer Registry of Norway, Norway, 4 University of Southern California, USA, ⁵Norwegian Knowledge Centre for the Health Services, Norway ABSTRACTS Background: It is unclear whether vitamin D intake is associated with breast cancer risk. There is some, albeit inconsistent, evidence that mammographic density (MD) varies by season of the year or by vitamin D intake. We evaluated the association of MD with seasonality and vitamin D intake among a subset of women who participated in the Norwegian Breast Cancer Screening Program (NBCSP) in 2004 or in 2008. Methods: We conducted a cross-sectional study to examine the association of MD with vitamin D intake and seasonality among 2662 postmenopausal women aged 50-69 years. Vitamin D intake (estimated with and without taking into account supplement use) was ascertained through a self-administered questionnaire. Density on digitized analogue films was measured using a computer assisted method (Madena, University of Southern California). Linear regression methods were used to determine the association of MD with vitamin D intake and the season in which the mammogram was obtained. Specifically we estimated least square means of MD across categories of the exposure variables, while adjusting for potential confounders. Results: There was no association between intake of vitamin D and MD, across quartiles of vitamin D intake (0-5, 6-8, 9-12 and 13-49 mcg per day, estimated with supplements). Mean MD was 18.5% (SD=15.3%) in women with the lowest, and 18.9% (SD=15.6%) in women with the highest intake of vitamin D (p for trend=0.73). There was no association between vitamin D intake and MD in women who had their mammogram during January-May, i.e. at the time when vitamin D levels are presumed to be at the lowest (p for trend= 0.10). Similarly, there was no statistical significant association between month of mammography and MD in either the 2004 or the 2008 data. Conclusion: Our cross-sectional study found no evidence of an association of MD with vitamin D intake or month/season of mammography. 47
Page 1: 6 th International
Page 4 and 5: 6 th International
Page 6 and 7: PROGRAM 6 th International<
Page 8 and 9: BREAST DENSITY - WHAT IS A WOMAN TO
Page 10 and 11: ABSTRACTS FOR SPEAKERS 6 th <strong
Page 32 and 33: P1 6 th International</stro
Page 44 and 45: P10 6 th International</str
Page 90 and 91: 88 6 th International</stro
Page 98:
6 th International
show all

6th International Workshop on Breast Densitometry and Breast ...

Create successful ePaper yourself

Delete template?

Save as template?