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British Guideline on the MAnAGeMent of AsthMA<br />
26<br />
Measurement Methodology<br />
Airway<br />
responsiveness<br />
108<br />
Exhaled nitric<br />
oxide (FENO)<br />
103, 119, 120,840,844<br />
78, 85,<br />
Only available in<br />
selected secondary<br />
care facilities.<br />
Responsive to<br />
change (particularly<br />
indirect challenges<br />
such as inhaled<br />
mannitol).<br />
Less of a ceiling<br />
effect than FEv and 1<br />
PEF.<br />
Not applicable<br />
in patients with<br />
impaired lung<br />
function (ie FEv / 1<br />
FvC 25<br />
ppb in children)<br />
predictive of a<br />
positive response to<br />
corticosteroids.<br />
The evidence that<br />
FENO can be used to<br />
guide corticosteroid<br />
treatment is mixed.<br />
Protocols for<br />
diagnosis and<br />
monitoring have not<br />
been well defined<br />
and more work is<br />
needed.<br />
Low FENO (
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