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British Guideline on the MAnAGeMent of AsthMA<br />

6.3.13 NON-INvASIvE vENTILATION<br />

66<br />

Non-invasive ventilation (NIv) is well established in the management of ventilatory failure<br />

caused by extrapulmonary restrictive conditions and exacerbations of COPD. Hypercapneic<br />

respiratory failure developing during an acute asthmatic episode is an indication for urgent ICU<br />

admission. It is unlikely that NIv would replace intubation in these very unstable patients but<br />

it has been suggested that this treatment can be used safely and effectively. 442<br />

A Cochrane review found only one trial, with 30 patients, on NIv which showed improvement<br />

in hospitalisation rates, discharge from emergency departments and lung function. Larger RCTs<br />

are needed to determine the role of NIv in treating patients with acute asthma. 796<br />

; NIv should only be considered in an ICU or equivalent clinical setting.<br />

6.4 further investiGAtion And MonitorinG<br />

; Measure and record PEF 15-30 minutes after starting treatment, and thereafter<br />

according to the response. Measure and record PEF before and after nebulised or<br />

inhaled β 2 agonist bronchodilator (at least four times daily) throughout the hospital<br />

stay and until controlled after discharge.<br />

Record oxygen saturation by oximetry and maintain arterial SpO 2 at 94-98%.<br />

Repeat measurements of blood gas tensions within one hour of starting treatment if:<br />

- the initial PaO 2 is 92%; or<br />

- the initial PaCO 2 is normal or raised; or<br />

- the patient’s condition deteriorates.<br />

; Measure them again if the patient’s condition has not improved by 4-6 hours.<br />

Measure and record the heart rate.<br />

Measure serum potassium and blood glucose concentrations.<br />

Measure the serum theophylline concentration if aminophylline is continued for more<br />

than 24 hours (aim at a concentration of 10-20mg/l or 55-110 mol/l).<br />

6.5 AsthMA MAnAGeMent ProtoCols And ProforMAs<br />

The use of structured proformas facilitates improvements in the process of care in emergency<br />

departments and hospital wards and improves patient outcomes. The use of this type<br />

of documentation can assist data collection aimed at determining quality of care and<br />

outcomes. 409,443,445<br />

6.6 hosPitAl disChArGe And folloW uP (see annex 4)<br />

6.6.1 TIMING OF DISCHARGE<br />

No single physiological parameter defines absolutely the timing of discharge from an admission<br />

with acute asthma. Patients should have clinical signs compatible with home management, be<br />

on reducing amounts of β 2 agonist (preferably no more than four hourly) and be on medical<br />

therapy they can continue safely at home.<br />

Although diurnal variability of PEF is not always present during an exacerbation, evidence<br />

suggests that patients discharged with PEF 25% are at greater risk of early relapse and readmission. 446,447<br />

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