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British Guideline on the MAnAGeMent of AsthMA<br />
6.3.13 NON-INvASIvE vENTILATION<br />
66<br />
Non-invasive ventilation (NIv) is well established in the management of ventilatory failure<br />
caused by extrapulmonary restrictive conditions and exacerbations of COPD. Hypercapneic<br />
respiratory failure developing during an acute asthmatic episode is an indication for urgent ICU<br />
admission. It is unlikely that NIv would replace intubation in these very unstable patients but<br />
it has been suggested that this treatment can be used safely and effectively. 442<br />
A Cochrane review found only one trial, with 30 patients, on NIv which showed improvement<br />
in hospitalisation rates, discharge from emergency departments and lung function. Larger RCTs<br />
are needed to determine the role of NIv in treating patients with acute asthma. 796<br />
; NIv should only be considered in an ICU or equivalent clinical setting.<br />
6.4 further investiGAtion And MonitorinG<br />
; Measure and record PEF 15-30 minutes after starting treatment, and thereafter<br />
according to the response. Measure and record PEF before and after nebulised or<br />
inhaled β 2 agonist bronchodilator (at least four times daily) throughout the hospital<br />
stay and until controlled after discharge.<br />
Record oxygen saturation by oximetry and maintain arterial SpO 2 at 94-98%.<br />
Repeat measurements of blood gas tensions within one hour of starting treatment if:<br />
- the initial PaO 2 is 92%; or<br />
- the initial PaCO 2 is normal or raised; or<br />
- the patient’s condition deteriorates.<br />
; Measure them again if the patient’s condition has not improved by 4-6 hours.<br />
Measure and record the heart rate.<br />
Measure serum potassium and blood glucose concentrations.<br />
Measure the serum theophylline concentration if aminophylline is continued for more<br />
than 24 hours (aim at a concentration of 10-20mg/l or 55-110 mol/l).<br />
6.5 AsthMA MAnAGeMent ProtoCols And ProforMAs<br />
The use of structured proformas facilitates improvements in the process of care in emergency<br />
departments and hospital wards and improves patient outcomes. The use of this type<br />
of documentation can assist data collection aimed at determining quality of care and<br />
outcomes. 409,443,445<br />
6.6 hosPitAl disChArGe And folloW uP (see annex 4)<br />
6.6.1 TIMING OF DISCHARGE<br />
No single physiological parameter defines absolutely the timing of discharge from an admission<br />
with acute asthma. Patients should have clinical signs compatible with home management, be<br />
on reducing amounts of β 2 agonist (preferably no more than four hourly) and be on medical<br />
therapy they can continue safely at home.<br />
Although diurnal variability of PEF is not always present during an exacerbation, evidence<br />
suggests that patients discharged with PEF 25% are at greater risk of early relapse and readmission. 446,447<br />
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