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British Guideline on the MAnAGeMent of AsthMA 26 Measurement Methodology Airway responsiveness 108 Exhaled nitric oxide (FENO) 103, 119, 120,840,844 78, 85, Only available in selected secondary care facilities. Responsive to change (particularly indirect challenges such as inhaled mannitol). Less of a ceiling effect than FEv and 1 PEF. Not applicable in patients with impaired lung function (ie FEv / 1 FvC 25 ppb in children) predictive of a positive response to corticosteroids. The evidence that FENO can be used to guide corticosteroid treatment is mixed. Protocols for diagnosis and monitoring have not been well defined and more work is needed. Low FENO (
Measurement Methodology Eosinophil differential count in induced sputum 83,84,121,122,844 Only available in specialist centres although technology is widely available and inexpensive. Information available in 80-90% of patients although immediate results are not available. Sputum eosinophil count not closely related to other measures of asthma morbidity Measurement characteristics Normal range
Page 1 and 2: 101 British Guideline on the Manage
Page 3 and 4: British Thoracic Society Scottish I
Page 5 and 6: Revised 2011 Revised 2011 Revised 2
Page 7 and 8: 1 introduction 1.1 the need for A G
Page 9 and 10: 1.3.1 PATIENT vERSION Patient versi
Page 11 and 12: Table 1: Clinical features that inc
Page 13 and 14: Case detection studies have used sy
Page 15 and 16: 2.1.6 CHILDREN WITH AN INTERMEDIATE
Page 17 and 18: 2.3 suMMAry focus the initial asses
Page 19 and 20: 2.4 diAGnosis in Adults The diagnos
Page 21 and 22: 2.4.1 FURTHER INvESTIGATION OF PATI
Page 23 and 24: Table 6: Differential diagnosis of
Page 25 and 26: 2.5.1 TREATMENT TRIALS AND REvERSIB
Page 27 and 28: A small prospective observational s
Page 29 and 30: Table 8: Summary of tools that can
Page 31: Measurement Methodology Asthma Cont
Page 35 and 36: 3.1.2 FOOD ALLERGEN AvOIDANCE Sensi
Page 37 and 38: The limited data on antenatal or ea
Page 39 and 40: 3.3.2 AIR POLLUTION Challenge studi
Page 41 and 42: 3.5 CoMPleMentAry And AlternAtive M
Page 43 and 44: Revised 2011 4 Pharmacological mana
Page 45 and 46: Table 8b: Equivalent doses of inhal
Page 47 and 48: 4.2.3 SAFETy OF INHALED STEROIDS Th
Page 49 and 50: 4.3.2 ADD-ON THERAPy Options for ad
Page 51 and 52: 4.4 steP 4: Poor Control on ModerAt
Page 53 and 54: 4 PhArMAColoGiCAl MAnAGeMent Colchi
Page 55 and 56: MOVE UP TO IMPROVE CONTROL AS NEEDE
Page 57 and 58: 4.6 stePPinG doWn Stepping down the
Page 59 and 60: 4.7.5 ASPIRIN-INTOLERANT ASTHMA The
Page 61 and 62: 5.3 inhAled steroids for stABle Ast
Page 63 and 64: Revised 2009 6 Management of acute
Page 65 and 66: Patients with brittle or difficult
Page 67 and 68: Table 11: Initial assessment - the
Page 69 and 70: In acute asthma without life threat
Page 71 and 72: 6.3.8 ANTIBIOTICS 6.3.9 HELIOx When
Page 73 and 74: 6.6.2 PATIENT EDUCATION Following d
Page 75 and 76: 6.7.2 PULSE OxIMETRy 6.7.3 PEF Accu
Page 77 and 78: Frequent doses up to every 20-30 mi
Page 79 and 80: 6.9.3 Iv MAGNESIUM SULPHATE Intrave
Page 81 and 82: New 2011 7 special situations 7.1 A
Page 83 and 84:
Gender During adolescence there is
Page 85 and 86:
Complementary and alternative medic
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Table 13: Recommendations for organ
Page 89 and 90:
7.2 diffiCult AsthMA 7.2.1 DEFINING
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Revised 2009 Controlled studies usi
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Continuous fetal monitoring should
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C use steroid tablets as normal whe
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7.9.2 AT-RISK POPULATIONS Several h
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7.9.6 SPECIFIC BRONCHIAL PROvOCATIO
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Asthma clinics in primary care may
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A 8.3 Audit discharge from hospital
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9 Patient education and self manage
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9.2.1 COMPLIANCE WITH MONITORING AN
Page 109 and 110:
Table 15. Summary of the key compon
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8. What role does patient preferenc
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Dr James Paton* Reader and Honorary
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INHALER DEvICES Dr John White (Chai
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11.4 disseMinAtion GrouP Mrs Sheila
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Abbreviations ABG arterial blood ga
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Annex 2 Management of acute severe
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Annex 4 Features of acute severe as
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Annex 6 Consider prednisolone 20 mg
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Annex 8 Management of acute asthma
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Annex 10 PEF (l/min) EU Scale 680 6
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Annex 11 (contd) Annexes 125
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56. Abu-Hasan M, Tannous B, Weinber
Page 135 and 136:
156. Lodrup Carlsen KC, Carlsen KH,
Page 137 and 138:
256. Malmstrom M, Ahlner J, Carlsso
Page 139 and 140:
352. Brocklebank D, Ram F, Wright J
Page 141 and 142:
456. McDowell KM, Chatburn RL, Myer
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562. McDonald JC, Keynes HL, Meredi
Page 145 and 146:
668. Enright PL, McClelland RL, New
Page 147 and 148:
767. Berger W. Budesonide inhalatio
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862. Pedroletti C, Lundahl J, Alvin
Page 151:
ISBN 978 1 905813 28 5 British Thor
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