McClure, CooperWorkloadA number of case reports highlight that peak labour wardactivity coincided with the emergency admission of a pregnantwoman with an acute, severe illness. Many notes suggestthat the midwifery, obstetric and anaesthetic workforcewas already fully committed at times of peak activity innormal workload. This produces difficulties if a pregnantwoman with an acute, severe illness is admitted andrequires high-dependency care in addition. When staffinglevels are calculated on average activity, there needs <strong>to</strong> be aclear contingency plan for all disciplines <strong>to</strong> obtain furtherskilled assistance.Workload: learning pointA clear contingency plan <strong>to</strong> provide additional skilledassistance should be in place if maternity staff arealready fully committed at times of peak activity, if awoman with an acute, severe illness requires highdependencycare.Serious incidents and hospital enquiriesMost <strong>maternal</strong> <strong>deaths</strong> within hospital now initiate a fullserious incident or internal hospital enquiry, the reports ofwhich were available <strong>to</strong> the Regional and Central Assessors.These reports are still of variable quality and clearly completedin-house and therefore open <strong>to</strong> bias. Hospital managersare again asked <strong>to</strong> consider whether unbiased externalinput would assist in this process and ensure greater objectivity.Disclosure of interestsJ McClure was a Clinical Research Fellow for one year(1979) sponsored by Astra Pharmaceuticals (now AstaZeneca)and has undertaken consultancy work and one sponsoredlecture <strong>to</strong>ur since – the association ended over10 years ago.G Cooper has no interests <strong>to</strong> disclose.FundingThis work was undertaken by the Centre for Maternal andChild Enquiries (CMACE) as part of the CEMACH programme.The work was funded by the National PatientSafety Agency; the Department of Health, Social Servicesand Public Safety of Northern Ireland; NHS QualityImprovement Scotland (NHS QIS); and the ChannelIslands and Isle of Man.AcknowledgementsThis Chapter has been peer reviewed by the new CentralAnaesthetic Assessors, Dr Steve Yentis, Consultant Anaesthetistfor Chelsea and Westminster Hospital and Dr PaulClyburn, Consultant Anaesthetist for University Hospital ofWales and the UK Regional Assessors in Anaesthesia. jReferences1 Difficult Airway Society Guidelines. [www.das.uk.com/guidelines/downloads.html]. Accessed 9 September 2010.2 Scott DB. Endotracheal intubation: friend or foe. BMJ1986;292:157–8.3 Department of Health and Social Security. Report on confidential enquiriesin<strong>to</strong> <strong>maternal</strong> <strong>deaths</strong> in England and Wales 1967–1969. London,UK: HMSO, 1972.4 CCT in Anaesthetics. Curriculum, annex B—basic level training.[www.rcoa.ac.uk/docs/CCTAnnexB.pdf]. Accessed 9 September2010.5 Searle RD, Lyons G. Vanishing experience in training for obstetricgeneral anaesthesia: an observational study. Int J Obstet Anesth<strong>2008</strong>;17:233–7.6 Rahman K, Jenkins JG. Failed tracheal intubation in obstetrics: nomore frequent but still managed badly. Anaesthesia 2005;60:168–71.7 Bromiley M. Have you ever made a mistake? A Patient Liaison GroupDebate. R Coll Anaesth Bull <strong>2008</strong>;48:2442–5.8 Rhodes A, Hughes KR, Cohen DG. An argument for orogastric tubesduring caesarean section. Int J Obstet Anesth 1996;5:156–9.9 Knight M. Peripartum hysterec<strong>to</strong>my in the UK: management andoutcomes of the associated haemorrhage. BJOG 2007;114:1380–7.10 CMACE/RCOG. Management of women with obesity in pregnancy.London, UK: Centre for Maternal and Child Enquiries and Royal Collegeof Obstetricians and Gynaecologists. <strong>March</strong> 2010. [www.cmace.org.uk].Accessed 9 September 2010.11 Howell C, Grady K, Cox C. Managing Obstetric Emergencies andTrauma—the MOET Course Manual, 2nd edn. London, UK: RCOGPress; 2007.12 Resuscitation Council (UK). Anaphylaxis algorithm. London: ResuscitationCouncil (UK), <strong>2008</strong>.13 The Association of Anaesthetists of Great Britain & Ireland AnaphylaxisGuideline. Management of a Patient with Suspected AnaphylaxisDuring Anaesthesia: Safety drill. London: the Association ofAnaesthetists of Great Britain & Ireland, 2009.14 Royal College of Obstetricians and Gynaecologists. Green-TopGuideline No. 37. Reducing the risk of thrombosis and embolismduring pregnancy and the puerperium. London: Royal College ofObstetricians and Gynaecologists, 2009.108 ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203
Chapter 9: Cardiac diseaseChapter 9: Cardiac diseaseC Nelson-PiercyGuy’s & St Thomas’ Foundation Trust and Imperial College Healthcare Trust, Women’s Health Direc<strong>to</strong>rate, London, UKCorrespondence: Professor Catherine Nelson-Piercy, Guy’s & St Thomas’ Foundation Trust and Imperial College Healthcare Trust, Women’sHealth Direc<strong>to</strong>rate, 10th Floor, North Wing, Westminster Bridge Road, London SE1 7EH, UK. Email: catherine.nelson-piercy@gstt.nhs.ukKeywords cardiac disease, Confidential Enquiry, <strong>maternal</strong>,mortality.Cardiac disease: specific recommendation• Women with a known his<strong>to</strong>ry of cardiac disease must be referred for consultant-led obstetric care in a maternity unitwhere there is a joint obstetric/cardiology clinic or a cardiologist with expertise in the care of women with heart diseasein pregnancy.Cardiac disease: learning pointsThere must be a low threshold for further investigationof pregnant or recently delivered women who complainof chest pain that is severe, or radiates <strong>to</strong> the neck, jawor back, or is associated with other features such as agitation,vomiting or breathlessness, tachycardia, tachypnoea,orthopnea or acidosis. This is especially importantfor women who smoke, are obese or who have hypertension.Appropriate investigations <strong>to</strong> rule out, orconfirm, cardiac disease or aortic dissection includean electrocardiogram (ECG), a chest X-ray, cardiacenzymes (Troponin), an echocardiogram and computed<strong>to</strong>mography pulmonary angiography.Women with chest, back or epigastric pain severeenough <strong>to</strong> require opiate analgesia must be fully investigatedfor all possible causes, including cardiac disease.Wheezing can be a feature of pulmonary oedema as wellas asthma. Pulmonary oedema requires investigationwith a chest X-ray and an echocardiogram and oxygensaturation.Arterial blood gases are frequently measured wheninvestigating suspected pulmonary embolus and mayalso provide important information about underlyingcardiac disease. Hypoxaemia is a feature of pulmonaryoedema, and a metabolic acidosis (increased base excess,reduced bicarbonate), with or without an elevated serumlactate, is a feature of a reduced cardiac output secondary<strong>to</strong> cardiac disease.The curriculum and training of obstetricians followingthe advanced training skills module in <strong>maternal</strong> medicineand <strong>maternal</strong> and fetal medicine subspecialisationshould reflect the importance of heart disease as a causeof <strong>maternal</strong> death. Such training should equip theobstetrician with knowledge of when and which womenwith pre-existing or new onset heart disease <strong>to</strong> refer <strong>to</strong>specialists.IntroductionThe <strong>deaths</strong> of 53 women who died from heart disease associatedwith, or aggravated by, pregnancy were reported <strong>to</strong> theEnquiry in <strong>2006</strong>–08. These are classified as Indirect <strong>maternal</strong><strong>deaths</strong>. This gives a <strong>maternal</strong> mortality rate for cardiac diseasefor <strong>2006</strong>–08 of 2.31 per 100 000 maternities (95% CI1.77–3.03) compared with 2.27 and 2.20 per 100 000 maternities(95% CIs 1.67–2.96 and 1.64–2.96, respectively, for theprevious two triennia as shown in Table 9.1. It thereforeremains not only the commonest cause of Indirect <strong>maternal</strong>death but the commonest cause overall.In addition <strong>to</strong> these women, lessons arising from eigh<strong>to</strong>ther women known <strong>to</strong> the Enquiry who died from cardiacdisease later after delivery are discussed and consideredhere, although they are counted as Late <strong>deaths</strong> in Chapter12. Of these, there were six Late Indirect cardiac <strong>deaths</strong>ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203 109
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