NeilsonConclusionThe number of <strong>deaths</strong> from pre-eclampsia/eclampsia has notfallen. The most pressing need, as before, is <strong>to</strong> treat hypertension(and especially sys<strong>to</strong>lic hypertension) quickly and effectively<strong>to</strong> prevent haemorrhagic stroke. Iatrogenichypertension should be avoided by abandoning the use ofergometrine in routine third-stage management. The incidenceof eclampsia has halved in the UK, presumably as aresult of the widespread use of magnesium sulphate, followingpublication of the Magpie trial. 7 The UKOSS study hasshown that the overall case fatality rate associated witheclampsia is low in the UK, but serious morbidity can occur. 2However, this Enquiry, albeit over a different time-scale, hasidentified an unprecedented number of <strong>deaths</strong> associatedwith eclamptic seizures. This is a reminder that eclampsia is aserious complication that, where possible, should be avoided.Disclosure of interestsNone.FundingThis work was undertaken by the Centre for Maternal andChild Enquiries (CMACE) as part of the CEMACH programme.The work was funded by the National PatientSafety Agency; the Department of Health, Social Servicesand Public Safety of Northern Ireland; NHS QualityImprovement Scotland (NHS QIS); and the ChannelIslands and Isle of Man.AcknowledgementsThis chapter has been seen and discussed with Mr StevenWalkinshaw, Consultant Obstetrician of LiverpoolWomen’s Hospital. The Pathology overview was written byDr H Millward-Sadler, Consultant His<strong>to</strong>pathologist ofSouthamp<strong>to</strong>n University Hospitals NHS Trust. jReferences1 Knight M, Nelson-Piercy C, Kurinczuk JJ, Spark P, Brocklehurst P. Aprospective national study of acute fatty liver of pregnancy in the UK.Gut <strong>2008</strong>;57:951–<strong>6.</strong>2 Knight M. Eclampsia in the United Kingdom 2005. BJOG2007;114:1072–8.3 Douglas KA, Redman CW. Eclampsia in the United Kingdom. BMJ1994;309:1395–400.4 National Collaborating Centre for Women’s and Children’s Health.Hypertension in Pregnancy: The Management of Hypertensive DisordersDuring Pregnancy. National Institute for Health and Clinical ExcellenceGuideline 107. London: RCOG. August 2010. [www.guidance.nice.org.uk/CG107/]. Accessed 5 Oc<strong>to</strong>ber 2010.5 McDonald SJ, Abbott JN, Higgins SP. Prophylactic ergometrine-oxy<strong>to</strong>cinversus oxy<strong>to</strong>cin for the third stage of labour. Cochrane DatabaseSyst Rev 2004;Issue 1:CD000201.6 National Collaborating Centre for Women’s and Children’s Health. IntrapartumCare. Care of Healthy Women and their Babies DuringChildbirth. London: RCOG. Revised Report <strong>2008</strong>. [http://www.ncc-wch.org.uk/guidelines/guidelilnes-programme/guidelines-programmepublished/intrapartum-care/]Accessed 5 Oc<strong>to</strong>ber 2010.7 Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, et al. Dowomen with pre-eclampsia, and their babies, benefit from magnesiumsulphate? The Magpie Trial: a randomised placebo-controlledtrial Lancet 2002;359:1877–90.70 ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203
Chapter 4: HaemorrhageChapter 4: HaemorrhageJ Norman (on behalf of the Centre for Maternal and Child Enquiries)University of Edinburgh Centre for Reproductive Biology, The Queens Medical Research Institute, Edinburgh, UKCorrespondence: Professor Jane Norman, Chair of Maternal and Fetal Health, University of Edinburgh Centre for Reproductive Biology, TheQueens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Email: jane.norman@ed.ac.uk. Keywords obstetric haemorrhage, Confidential Enquiry, <strong>maternal</strong>,mortality.Obstetric haemorrhage: specific recommendation• Despite the decline in numbers this triennium, obstetric haemorrhage remains an important cause of <strong>maternal</strong> death.All units should have pro<strong>to</strong>cols in place for its identification and management, and all clinicians responsible for thecare of pregnant women, antenatally, postnatally and intrapartum, including those practicing in the community,should carry out regular skills training for such scenarios.• Early senior multidisciplinary team involvement is essential in the management of major obstetric haemorrhage.• All clinicians should be aware of the guidelines for management of women who refuse blood transfusion.• The welcome absence of <strong>deaths</strong> in relation <strong>to</strong> elective caesarean section for placenta praevia in this Report endorsesthe recommendations in earlier Reports that senior staff should be involved in these deliveries.• The recommendation in the previous Report that ‘All women who have had a previous caesarean section must havetheir placental site determined. If there is any doubt, magnetic resonance imaging (MRI) can be used along with ultrasoundscanning in determining if the placenta is accreta or percreta’ needs <strong>to</strong> be restated, as scans for placental localisationsite in women with previous caesarean sections are still sometimes not being performed.• Women delivered by caesarean section should have regular observations of pulse and blood pressure for the first24 hours after delivery recorded on a Modified Early Obstetric Warning score (MEOWS) chart. Abnormal scores onMEOWS should be investigated and acted upon immediately.• The Royal College of Obstetricians and Gynaecologists (RCOG) recommend that women with major placenta praeviawho have previously bled should be admitted and managed as inpatients from 34 weeks of gestation. Those withmajor placenta praevia who remain asymp<strong>to</strong>matic, having never bled, require careful counselling before contemplatingoutpatient care. Women with major placenta praevia who elect <strong>to</strong> remain at home should have the risks explained <strong>to</strong>them and ideally require close proximity with the hospital.Obstetric haemorrhage: learningpointsAnaemia magnifies the effects of obstetric haemorrhage.Antenatal anaemia should be diagnosed and treatedeffectively: parenteral iron therapy should be consideredantenatally for women with iron deficiency anaemiawho do not respond <strong>to</strong> oral iron.Moderate or excessive traction on the cord before placentalseparation is inappropriate. The appropriate initialmanagement of uterine inversion is attemptedreplacement.Any decision <strong>to</strong> give women blood should be madecarefully, and all clinicians involved in blood transfusionshould be aware of the potential adverse effects of transfusionand signs and symp<strong>to</strong>ms of transfusion-relatedcomplications.Women known <strong>to</strong> be at risk of major haemorrhage, e.g.those with placenta accreta and those who decline bloodand blood products, should be delivered in maternityunits with access <strong>to</strong> critical care, interventional radiologyand cell salvage.ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203 71
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