Oates, CantwellChapter 11: Deaths from psychiatric causesM Oates 1 , R Cantwell 2 (on behalf of the Centre for Maternal and Child Enquiries)1 East Midlands Perintal Mental Health Clinical Network, Nottinghamshire Healthcare NHS Trust, Nottingham, UK; 2 Perinatal Mental HealthService, Southern General Hospital, Glasgow, UKCorrespondence: Dr Margaret R Oates, East Midlands Perintal Mental Health Clinical Network, Nottinghamshire Healthcare NHS Trust,Duncan MacMillan House, Porchester Road, Nottingham NG3 6AA, UK. Email: margaret.oates@nottshc.nhs.ukKeywords psychiatric, psychosis, suicide, Confidential Enquiry,<strong>maternal</strong>, mortality.Psychiatric <strong>deaths</strong>: specific recommendations• As has been recommended before, but re-emphasised here, all women should be asked at their antenatal booking visitabout a previous his<strong>to</strong>ry of psychiatric disorder as well as their current mental health. Women with a previous his<strong>to</strong>ryof serious affective disorder or other psychoses should be referred in pregnancy for psychiatric assessment and managementeven if they are well. A minimum requirement for management should be regular moni<strong>to</strong>ring and supportfor at least 3 months following delivery.• Psychiatric services should have priority care pathways for pregnant and postpartum women. These will include a loweredthreshold for referral and intervention, including admission and a rapid response time, for women in late pregnancyand the first 6 weeks following delivery. Care by multiple psychiatric teams should be avoided. Risk assessments of pregnan<strong>to</strong>r postpartum women should be modified <strong>to</strong> take account of risk associated with previous his<strong>to</strong>ry, the distinctiveclinical picture of perinatal disorders and the violent method of suicide.• All mental health trusts should have specialised community perinatal mental teams <strong>to</strong> care for pregnant and postpartumwomen. These should be closely integrated with regional mother and baby units so that all women requiring psychiatricadmission in late pregnancy and the postpartum period can be admitted <strong>to</strong>gether with their infants.• Caution needs <strong>to</strong> be exercised when diagnosing psychiatric disorder if the only symp<strong>to</strong>ms are either unexplained physicalsymp<strong>to</strong>ms or distress and agitation. This is particularly so when the woman has no prior psychiatric his<strong>to</strong>ry orwhen she does not speak English or comes from an ethnic minority.Introduction and backgroundAs in previous Reports, this chapter describes the keyfeatures of, and derives lessons from, those <strong>maternal</strong><strong>deaths</strong> arising directly from a psychiatric condition, suicideor accidental overdose of drugs of abuse, as well as<strong>deaths</strong> from medical or other causes closely related <strong>to</strong> apsychiatric disorder. These latter <strong>deaths</strong> include thosefrom the physical consequences of substance misuse anddelays in diagnosis and treatment because of the presenceor assumption of a psychiatric disorder, accidents andviolence.Perinatal psychiatric disorderPsychiatric disorder during pregnancy and following deliveryis common, both new episodes and recurrences of preexistingconditions. Ten percent of new mothers are likely<strong>to</strong> develop a depressive illness, 1 of whom between a thirdand a half will be suffering from a severe depressive illness. 2At least 2% of new mothers will be referred <strong>to</strong> a psychiatricteam during this time, and two per thousand will sufferfrom a puerperal psychosis. 3The majority of women who develop mental healthproblems during pregnancy or following delivery sufferfrom mild depressive illness, often with accompanying anxiety.Such conditions are probably no more common thanat other times. In contrast, the risk of developing a seriousmental illness (bipolar disorder, other affective psychosesand severe depressive illness) is reduced during pregnancybut markedly elevated following childbirth, particularlyduring the first 3 months. 4The prevalence of all psychiatric disorders, includingsubstance misuse, schizophrenia and obsessive compulsive132 ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203
Chapter 11: Deaths from psychiatric causesdisorder, is the same at conception as in the nonpregnantfemale population. Pregnancy is not protective againstrelapses of pre-existing serious mental illness, particularly ifthe woman has s<strong>to</strong>pped her usual medication at the beginningof pregnancy.Women who have had a previous episode of a seriousmental illness, either following childbirth or at other times,are at an increased risk of developing a postpartum onsetillness, even if they have been well during pregnancy andfor many years previously. This risk is estimated as at leas<strong>to</strong>ne in two, that is these women have a 50% chance of itrecurring in a subsequent pergnancy. 5,6 The last threeReports 7–9 also found that over half of the women whodied from suicide had a previous his<strong>to</strong>ry of serious mentalillness. It is also known that a family his<strong>to</strong>ry of bipolar disorderincreases the risk of a woman developing puerperalpsychosis following childbirth. 6Specialist perinatal psychiatricservicesSerious psychiatric illnesses in the last few weeks of pregnancyand the first few weeks following childbirth have a number ofdistinctive clinical features including, importantly, the tendencyfor sudden onset and rapid deterioration. Half of allwomen with puerperal psychoses will have presented by dayseven postnatally, and 90% by 3 months postpartum, 4 ashighlighted in the last three Reports. This, <strong>to</strong>gether withother distinctive symp<strong>to</strong>ms 10 and the special needs of womenand their infants at this time, has led <strong>to</strong> national and internationalacceptance of the need for special services for perinatalpsychiatric disorder. 11,12 This includes the recommendationthat new mothers who require admission <strong>to</strong> a psychiatric unitfollowing birth should be admitted <strong>to</strong>gether with their infant<strong>to</strong> a specialised mother and baby unit and that specialisedcommunity teams are available for those managed at home.The findings of the last three Enquiries underpin the importanceof this strategy, as, with few exceptions, the womenwho died had been cared for by non-specialised psychiatricteams unfamiliar with these conditions.Maternal suicideUntil recently, it had been thought that the <strong>maternal</strong> suiciderate in pregnancy was lower than would be expected, 13with pregnancy exerting a so-called ‘protective effect’. Thelast three Enquiry Reports found that <strong>maternal</strong> suicide wasmore common than previously thought and was a leadingoverall cause of <strong>maternal</strong> death. However, suicide duringpregnancy remains relatively uncommon, and the majorityof suicides associated with pregnancy occur following childbirth.Overall, the suicide rate following delivery is little different<strong>to</strong> that among women in the general population, butit may be that for a subgroup of women, those sufferingfrom serious mental illness, the suicide rate is substantiallyelevated. 14 One of the reasons for the misunderstandingabout <strong>maternal</strong> suicide is that research over the last40 years has consistently shown that rates based upon coroners’verdicts alone are underestimates. For the last four triennia,the Office for National Statistics (ONS) has beenable <strong>to</strong> link mothers’ <strong>deaths</strong> up <strong>to</strong> 1 year after delivery withrecorded births. This revealed that until 2002, around halfof all <strong>maternal</strong> suicides had not been reported directly <strong>to</strong>this Enquiry. Once this under-reporting was corrected, amore realistic estimate of <strong>maternal</strong> suicide was possible.Impact of previous enquiriesThe findings and recommendations of the last three Enquiries7–9 have influenced national policy and guidelines,including the New Horizons Vision for Mental Health, 11 TheNational Service Framework for Children, Young People andMaternity Services, 15 and the National Institute for Healthand Clinical Excellence (NICE) Guidelines for antenatal andpostnatal mental health. 12 All recommend that womenshould be asked at their early pregnancy assessment abouttheir current mental health and a previous his<strong>to</strong>ry of psychiatricdisorder. Those at risk of developing a serious mentalillness following delivery should be proactively managed.They also recommend that sufficient mother and baby unitsand specialised community perinatal teams should be established<strong>to</strong> manage women whose pregnancy or postpartumyear is complicated by serious mental illness. The recommendationsfor screening at booking have been widelyimplemented but by no means universally. Specialisedmother and baby units and perinatal psychiatric services arestill not available <strong>to</strong> women in many parts of the UK.Key findings <strong>2006</strong>–08Psychiatric disorder is common in pregnancy and afterdelivery, and this is reflected in this Report. Not all of the<strong>deaths</strong> described in this Chapter are counted as Indirect<strong>deaths</strong> due <strong>to</strong> psychiatric illness. As internationally definedand discussed in Chapter 1, the only <strong>deaths</strong> which fit in<strong>to</strong>this category are those women who committed suicide duringpregnancy or within 42 days (6 weeks) of the end oftheir pregnancy. There were 13 such women this triennium.Deaths from suicide after this time are classified asLate Indirect. This triennial Report includes only those<strong>deaths</strong> that occurred after 6 weeks and within 6 months(43–182 days) of delivery, of which there were 1<strong>6.</strong> In previousReports these <strong>deaths</strong> were followed up for a calendaryear after delivery, which <strong>make</strong>s a direct comparison withearlier Reports difficult. However, it has been possible <strong>to</strong>deduce some trends, and these are discussed later.ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203 133
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Volume 118, Supplement 1, March 201
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AcknowledgementsSaving Mothers’ L
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AcknowledgementsAcknowledgementsCMA
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Forewordbeen written jointly by a m
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‘Top ten’ recommendationsServic
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‘Top ten’ recommendationscommun
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‘Top ten’ recommendationsof suc
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‘Top ten’ recommendationsMarch
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Oates et al.Back to basicsM Oates 1
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Oates et al.BreathlessnessBreathles
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Oates et al.appropriate pathway of
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LewisIntroduction: Aims, objectives
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LewisAn important limitation of ran
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Lewismaternal and public health-pol
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Lewisresult in a live birth at any
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LewisChapter 1: The women who died
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Lewiswho would not have been identi
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Lewis1098Rate per 100 000 materniti
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LewisTable 1.4. Numbers and rates o
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Lewis2.50Rate per 100 000 materniti
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LewisTable 1.9. Number of maternal
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LewisThere were cases where a major
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LewisNew countries of the European
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Lewis4 Lewis G (ed). The Confidenti
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DrifeTable 2.1. Direct deaths from
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Drifewomen who died in 2006-08 had
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Drifedelivery she became breathless
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DrifePathological overviewFourteen
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NeilsonChapter 3: Pre-eclampsia and
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Neilsontrue, and what might be the
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NeilsonConclusionThe number of deat
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NormanBackgroundIn the UK, major ob
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Normanwhich there was catastrophic
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Normanrecommendations made in succe
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DawsonBox 5.1. The UK amniotic flui
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Dawsontry despite an extensive sear
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Lucas, Millward-Sadler95 mmHg. This
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Lucas, Millward-Sadleran agreed mai
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Annex 17.1. The main clinico-tholog
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MillerAppendix 1: The method of Enq
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MillerDatanotificationNotificationR
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Knight• investigating different m
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Knightbaseline incidence against wh
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LennoxAppendix 2B: Summary of Scott
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LennoxEvidence of effective managem
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Appendix 3: Contributors to the Mat
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Appendix 3: Contributors to the Mat