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N. Chatterjee 185right information about her risk from BRCA1/2 testing is just a reminderabout the challenge that lies ahead for all of us to use genetic and other typesof biomedical data to create objective “knowledge” that will benefit, and notmisguide or harm, medical researchers, clinicians and most importantly thepublic.ReferencesAllen, H.L. et al. (2010). Hundreds of variants clustered in genomic loci andbiological pathways affect human height. Nature, 467:832–838.Anderson, C.A., Boucher, G., Lees, C.W., Franke, A., D’Amato, M., Taylor,K.D., Lee, J.C., Goyette, P., Imielinski, M., Latiano, A. et al. (2011).Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasingthe number of confirmed associations to 47. Nature Genetics, 43:246–252.Bhattacharjee, S., Wang, Z., Ciampa, J., Kraft, P., Chanock, S., Yu, K., andChatterjee, N. (2010). Using principal components of genetic variationfor robust and powerful detection of gene-gene interactions in case-controland case-only studies. The American Journal of Human Genetics,86:331–342.Chatterjee, N., and Carroll, R.J. (2005). Semiparametric maximum likelihoodestimation exploiting gene-environment independence in casecontrolstudies. Biometrika, 92:399–418.Chatterjee, N., Chen, Y.-H., and Breslow, N.E. (2003). A pseudoscore estimatorfor regression problems with two-phase sampling. Journal of theAmerican Statistical Association, 98:158–168.Chatterjee, N., Kalaylioglu, Z., and Carroll, R.J. (2005). Exploiting geneenvironmentindependence in family-based case-control studies: Increasedpower for detecting associations, interactions and joint effects. GeneticEpidemiology, 28:138–156.Chatterjee, N. and Wacholder, S. (2001). A marginal likelihood approach forestimating penetrance from kin-cohort designs. Biometrics, 57:245–252.Chatterjee, N., Wheeler, B., Sampson, J., Hartge, P., Chanock, S.J., andPark, J.-H. (2013). Projecting the performance of risk prediction based onpolygenic analyses of genome-wide association studies. Nature Genetics,45:400–405.Eeles, R.A., Al Olama, A.A., Benlloch, S., Saunders, E.J., Leongamornlert,D.A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., Dennis, J.,