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358 A vignette of discoveryciate the necessity of exploratory analysis in such settings led to my currentwork in adaptive designs and their analysis.ReferencesAppelbaum, F., Meyers, J., Fefer, A., Flournoy, N., Cheever, N., Greenberg,M., Greenberg, P., Hackman, R., and Thomas, E. (1982). Nonbacterialnonfungal pneumonia following marrow transplantation in 100 identicaltwins. Transplantation,33:265–268.Bowden, R., Sayers, M., Flournoy, N., Newton, B., Banaji, M., Thomas, E.,and Meyers, J. (1986). Cytomegalovirus immune globulin and seronegativeblood products to prevent primary cytomegalovirus infection aftermarrow transplant. New England Journal of Medicine, 314:1006–1010.Flournoy, N. and Hearne, L. (1990). Quality Control for a Shared MultidisciplinaryDatabase. Marcel Dekker, New York, pp. 43–56.Meyers, J.D., Flournoy, N., and Thomas, E.D. (1980). Cytomegalovirus infectionand specific cell-mediated immunity after marrow transplant. TheJournal of Infectious Diseases, 142:816–824.Meyers, J.D., Flournoy, N., and Thomas, E.D. (1982). Nonbacterial pneumoniaafter allogeneic marrow transplantation. Reviews of Infectious Diseases,4:1119–1132.Meyers, J.D., Flournoy, N., and Thomas, E.D. (1986). Risk factors for cytomegalovirusinfection after human marrow transplant. The Journal ofInfectious Diseases, 153:478–488.Meyers, J.D., Leszczynski, J., Zaia, J.A., Flournoy, N., Newton, B., Snydman,D.R., Wright, G.G., Levin, M.L., and Thomas, E.D. (1983). Preventionof cytomegalovirus infection by cytomegalovirus immune globulin aftermarrow transplantation. Annals of Internal Medicine, 98:442–446.Neiman, P.E., Reeves, W., Ray, G., Flournoy, N., Lerner, K.G., Sale, G.E.,and Thomas, E.D. (1977). A prospective analysis of interstitial pneumoniaand opportunistic viral infection among recipients of allogeneic bonemarrow graphs. The Journal of Infectious Diseases, 136:754–767.Thomas, E.D., Buckner, C.D., Banaji, M., Clift, R.A., Fefer, A., Flournoy, N.,Goodell, B.W., Hickman, R.O., Lerner, K.G., Neiman, P.E., Sale, G.E.,Sanders, J.E., Singer, J., Stevens, M., Storb, R., and Weiden, P.L. (1977).One hundred patients with acute leukemia treated by chemotherapy, totalbody irradiation, and allogeneic marrow transplantation. Blood, 49:511–533.