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N. Chatterjee 187The risk of cancer associated with specific mutations of BRCA1 andBRCA2 among Ashkenazi Jews. New England Journal of Medicine,336:1401–1408.Umbach, D.M. and Weinberg, C.R. (1997). Designing and analysing casecontrolstudies to exploit independence of genotype and exposure. Statisticsin Medicine, 16:1731–1743.Wacholder, S., Hartge, P., Struewing, J.P., Pee, D., McAdams, M., Brody, L.,and Tucker, M. (1998). The kin-cohort study for estimating penetrance.American Journal of Epidemiology, 148:623–630.Yeager, M., Orr, N., Hayes, R.B., Jacobs, K.B., Kraft, P., Wacholder, S.,Minichiello, M.J., Fearnhead, P., Yu, K., Chatterjee, N. et al. (2007).Genome-wide association study of prostate cancer identifies a second risklocus at 8q24. Nature Genetics, 39:645–649.
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ContentsPrefacexviiContributorsI Th
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viii15 We live in exciting times 15
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x24.6 Open areas for research . . .
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xii36 Buried treasures 405Michael A
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xiv45.3 Multi-phase inference . . .
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PrefaceStatistics is the science of
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PrefacexixPart V comprises seven ar
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xxiiNancy FlournoyUniversity of Mis
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Part IThe history of COPSS
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4 A brief history of COPSSOnchiota
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6 A brief history of COPSSThe items
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8 A brief history of COPSSTABLE 1.1
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10 A brief history of COPSSwomen of
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12 A brief history of COPSSTABLE 1.
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16 A brief history of COPSS1.4.3 Ge
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20 A brief history of COPSSFor more
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2Reminiscences of the Columbia Univ
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I. Olkin 25Bechhofer, Allan Birnbau
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I. Olkin 27Milton Sobel was the tea
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3AcareerinstatisticsHerman Chernoff
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H. Chernoff 31given three-day basic
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H. Chernoff 33Savage tried to defen
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H. Chernoff 35In working on an arti
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H. Chernoff 37measure the loss as t
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H. Chernoff 39ReferencesAlbert, A.E
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4“. . . how wonderful the field o
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D.R. Brillinger 43He went on to be
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D.R. Brillinger 45Tukey wrote many
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D.R. Brillinger 4718. Personal comm
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50 Unorthodox journey to statistics
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6Statistics before and after my COP
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P.J. Bickel 616.3.1 Imperial Colleg
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P.J. Bickel 63make. This was first
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P.J. Bickel 65We eventually develop
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P.J. Bickel 67school interest, biol
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P.J. Bickel 69ReferencesBean, D., B
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P.J. Bickel 71Meinshausen, N., Bick
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74 Accidental biostatistics profess
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84 Passion for statisticsme is its
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86 Passion for statisticsTheir Biom
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88 Passion for statisticsthe first
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90 Passion for statisticsIn my expe
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92 Passion for statistics8.5 Job an
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94 Passion for statisticsperiod. An
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96 Passion for statisticsNeyman, J.
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98 Reflections on a statistical car
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100 Reflections on a statistical ca
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110 Science mixes it up with statis
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11Lessons from a twisted career pat
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J.S. Rosenthal 119My math professor
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J.S. Rosenthal 121contrary, it null
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J.S. Rosenthal 123of statistical re
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J.S. Rosenthal 125be open to whatev
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J.S. Rosenthal 12711.4 Final though
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130 Promoting equityand fellowship
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132 Promoting equityevaluate such e
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134 Promoting equityfor equity. But
Page 157 and 158: 136 Promoting equityAssistant Secre
Page 160: Part IIIPerspectives on the fieldan
Page 163 and 164: 142 Statistics in service to the na
Page 175 and 176: 154 Where are the majors? ArtBachel
Page 177 and 178: 156 Where are the majors?References
Page 179 and 180: 158 Exciting timesCritically, Efron
Page 181 and 182: 160 Exciting timesIn general I find
Page 183 and 184: 162 Exciting timesI entered the Uni
Page 185 and 186: 164 Exciting times15.3.3 Joining th
Page 187 and 188: 166 Exciting timesvariability of a
Page 189 and 190: 168 Exciting timesHabemma, J.D.F.,
Page 192 and 193: 16The bright future of applied stat
Page 194 and 195: R.A. Irizarry 173FIGURE 16.1Illustr
Page 196 and 197: R.A. Irizarry 17516.4 The bright fu
Page 198 and 199: 17The road travelled: From statisti
Page 200 and 201: N. Chatterjee 179the Kaplan-Meyer e
Page 202 and 203: N. Chatterjee 18117.4 Genome-wide a
Page 204 and 205: N. Chatterjee 183by any means. I ju
Page 206 and 207: N. Chatterjee 185right information
Page 210 and 211: 18Ajourneyintostatisticalgeneticsan
Page 212 and 213: X. Lin 191Ilearnedwhilemakingmyjour
Page 214 and 215: X. Lin 193these simple methods in p
Page 216 and 217: X. Lin 1950’s. The association be
Page 218 and 219: X. Lin 197expression, respectively.
Page 220 and 221: X. Lin 199skills through seminars,
Page 222: X. Lin 201Pearl, J. (2001). Direct
Page 225 and 226: 204 Women in statistics in Canadame
Page 227 and 228: 206 Women in statistics in CanadaIn
Page 229 and 230: 208 Women in statistics in CanadaA
Page 231 and 232: 210 Women in statistics in CanadaTh
Page 233 and 234: 212 Women in statistics in CanadaAl
Page 235 and 236: 214 Women in statistics in CanadaRe
Page 238 and 239: 20“The whole women thing”Nancy
Page 240 and 241: N.M. Reid 219et al., 2012a), and th
Page 242 and 243: N.M. Reid 2212% to all female facul
Page 244 and 245: N.M. Reid 223Aparalleltothiscouldbe
Page 246 and 247: N.M. Reid 225Happily for most reade
Page 248 and 249: N.M. Reid 227Billard, L. and Ferber
Page 250 and 251: 21Reflections on diversityLouise M.
Page 252 and 253: L.M. Ryan 231would never have even
Page 254 and 255: L.M. Ryan 23321.4 Gender issuesI’
Page 256: Part IVReflections on thediscipline
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238 Statistics’ two theoriesVioxx
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240 Statistics’ two theoriescontr
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242 Statistics’ two theorieswhere
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244 Statistics’ two theoriesall w
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246 Statistics’ two theoriesa cas
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248 Statistics’ two theoriesFrequ
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250 Statistics’ two theoriesAckno
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252 Statistics’ two theoriesMarsh
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254 Conditioning is the issueThe pr
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256 Conditioning is the issuewhich
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258 Conditioning is the issueathoug
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260 Conditioning is the issueHaar p
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262 Conditioning is the issueTABLE
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264 Conditioning is the issuetest t
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266 Conditioning is the issueBirnba
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268 DS perspective on statistical i
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282 Nonparametric Bayesthe meaning
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284 Nonparametric BayesPrior (25.1)
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286 Nonparametric Bayesperhaps one
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288 Nonparametric Bayesworks well f
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290 Nonparametric Bayesof Statistic
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26How do we choose our default meth
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A. Gelman 295and in the first cours
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A. Gelman 297distribution is a powe
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A. Gelman 299sampling) yet has beco
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A. Gelman 301Gelman, A. and Shalizi
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304 Serial correlation and Durbin-W
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310 Anon-asymptoticwalkics, statist
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312 Anon-asymptoticwalkγ(t, x) =
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314 Anon-asymptoticwalk28.2.3 Empir
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316 Anon-asymptoticwalkto Cirel’s
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318 Anon-asymptoticwalk28.4 Beyond
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320 Anon-asymptoticwalkBoucheron, S
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29The past’s future is now: What
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L. Billard 325bounce around, so tha
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L. Billard 327TABLE 29.1Airline dat
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L. Billard 32965931082471FIGURE 29.
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L. Billard 331FIGURE 29.5PCA based
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L. Billard 333ReferencesBickel, P.J
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30Lessons in biostatisticsNorman E.
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N.E. Breslow 337most of its statist
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N.E. Breslow 339from complete remis
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N.E. Breslow 341transplant and thos
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N.E. Breslow 343TABLE 30.1Regressio
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N.E. Breslow 34530.5 ConclusionThe
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N.E. Breslow 347Partin, A.W., Yoo,
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350 A vignette of discoveryEarly at
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352 A vignette of discoverythat int
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354 A vignette of discoveryobservat
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356 A vignette of discoveryTABLE 31
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358 A vignette of discoveryciate th
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360 Statistics and public health re
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33Statistics in a new era for finan
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T.L. Lai 371(Rush et al., 2004) tha
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T.L. Lai 373(2012). The monograph b
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T.L. Lai 375loss function and assum
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T.L. Lai 377ReferencesAit-Sahalia,
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T.L. Lai 379Salmon, F. (2012). The
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382 Meta-analyses and heterogeneity
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35Good health: Statistical challeng
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A.S. Whittemore 393form a useful fo
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A.S. Whittemore 395variate values.
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A.S. Whittemore 397the observed fla
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A.S. Whittemore 399represented, for
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A.S. Whittemore 401Consider, for ex
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A.S. Whittemore 403Venter, D.J., We
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36Buried treasuresMichael A. Newton
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M.A. Newton 407FIGURE 36.1The relat
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M.A. Newton 409When measured at sev
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M.A. Newton 411Mason, D.M. and Newt
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414 Survey samplingclustering. Anot
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416 Survey samplingobjective is the
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418 Survey samplingEstimators ̂q a
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420 Survey samplingagainst model mi
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422 Survey samplingwrong, so can we
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424 Survey samplinggood design-base
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426 Survey samplingBox, G.E.P. (198
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428 Survey samplingRubin, D.B. (197
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430 Environmental informaticsHastie
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432 Environmental informaticsthis w
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434 Environmental informaticsthe da
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436 Environmental informaticssatell
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438 Environmental informaticsThe mo
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440 Environmental informaticsThe ch
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442 Environmental informaticsFIGURE
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444 Environmental informatics38.6 T
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446 Environmental informaticserror
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448 Environmental informaticsMcLach
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39AjourneywithstatisticalgeneticsEl
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E.A. Thompson 453PopulationMeiosisG
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E.A. Thompson 455TABLE 39.2The chan
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E.A. Thompson 45739.5 The 2000s: As
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E.A. Thompson 459I have given many
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E.A. Thompson 461Fisher, R.A. (1922
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E.A. Thompson 463Schena, M., Shalon
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40Targeted learning: From MLE to TM
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M. van der Laan 467confidence inter
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M. van der Laan 46940.2.3 Target qu
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M. van der Laan 471the doubly censo
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M. van der Laan 47340.4 Super learn
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M. van der Laan 475has the general
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M. van der Laan 477should also be c
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M. van der Laan 479Petersen, M. and
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41Statistical model building, machi
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G. Wahba 483geometrical argument co
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G. Wahba 485matrix is a rank p proj
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G. Wahba 487as proposed by Vapnik a
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G. Wahba 489details. In Corrada Bra
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G. Wahba 491As is easy to see here
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G. Wahba 493ceedings of the Nationa
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G. Wahba 495Vapnik, V. (1995). The
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498 Sparsity and convexity .^ .^ FI
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500 Sparsity and convexityrecover t
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502 Sparsity and convexity Tes
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504 Sparsity and convexityReference
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43Features of Big Data and sparsest
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J. Fan 509chemotherapy is helpful f
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J. Fan 511Realizations of two indep
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J. Fan 513selection of genes or SNP
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J. Fan 515 65432100.05 0 0.05 0.1
Page 538 and 539:
J. Fan 5174(a) m=210(b) m=100250204
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J. Fan 519where · denotes the comp
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J. Fan 52143.8 ConclusionBig Data a
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J. Fan 523Hall, P., Titterington, D
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526 Rise of the machinesric regress
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528 Rise of the machines●●●
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530 Rise of the machines44.4.2 Case
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532 Rise of the machinesis that the
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534 Rise of the machinesFIGURE 44.5
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536 Rise of the machinesAcknowledge
Page 559 and 560:
538 NP-hard inferenceseem to apprec
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540 NP-hard inferencesignal or nois
Page 563 and 564:
542 NP-hard inferenceIn the stricte
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544 NP-hard inferenceover equivalen
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546 NP-hard inferencelarge to pass
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548 NP-hard inferenceTo illustrate
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550 NP-hard inferencemodel P Y (Y |
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552 NP-hard inferenceand accepted (
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554 NP-hard inferenceHere let us as
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556 NP-hard inferenceThe (middle) r
Page 579 and 580:
558 NP-hard inferenceunderstanding
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560 NP-hard inferenceBouman, P., Me
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562 NP-hard inferenceNason, G.P. (2
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46Inspiration, aspiration, ambition
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C.F.J. Wu 567works, he wrote of Pea
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C.F.J. Wu 569you will become, can p
Page 593 and 594:
572 Personal reflections on the COP
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48Publishing without perishing and
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M. Davidian 583tion research. He wa
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M. Davidian 585it accessible to pra
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M. Davidian 587emphasized the impor
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M. Davidian 589s/he needs to have f
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M. Davidian 591enjoy what you do, a
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594 Converting rejectionsespecially
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596 Converting rejectionsdecent sug
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598 Converting rejectionssay, espec
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600 Converting rejectionsfinal anal
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602 Converting rejectionsAnderson,
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50The importance of mentorsDonald B
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D.B. Rubin 607earlier). Wheeler was
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D.B. Rubin 609program at Harvard, s
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D.B. Rubin 61150.6 Interim time in
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D.B. Rubin 613my colleagues and stu
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616 Never ask for or give advicesum
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618 Never ask for or give adviceyou
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52Thirteen rulesBradley EfronDepart
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