Continued from page 61 – What is the Connection between Pesticides <strong>and</strong> Breast Cancer?Nifurthiazole √ IARC Possible PesticidePesticide: insecticide (termites), woodPentachlorophenol√ preservativePermethrin,Pesticide: insecticideSumithrin√Pesticide, air pollutant, widely used toSimazine (a Triazine √IARC Notcontrol weeds in food crops <strong>and</strong> in ponds,Herbicide)Classifiablealgae control in pools <strong>and</strong> fountains,detected at low levels in air, rainwater <strong>and</strong>surface waterSulfallateToxapheneTributyl Tin(chloride)Vinclozolin√IARC Possible;NTP ReasonablyanticipatedNTP Reasonablyanticipated√√√Pesticide: herbicide, used until early 1990sin U.S., exposure through ingestion ofresidues in food cropsPesticide: insecticidePesticide: biocide, rodent repellentPesticide: agricultural fungicide, used invineyardsBreast Cancer Fund ~ www.breastcancerfund.org 10/11/07* Silent Spring Institute’s Science Review published in Cancer in 2007 includes information on 216 animal mammarygl<strong>and</strong> carcinogens.†International Agency for Research on Cancer (IARC) carcinogenic risk classification is based on evaluation ofpotential tumor development at all sites, not only breast/mammary tissue. Categories include: Known, Probable,Possible <strong>and</strong> others. The National Toxicology Program (NTP), within the National Institute of Environmental HealthSciences of the National Institutes of Health, provides carcinogenicity ratings based on scientific evidence in bothanimals <strong>and</strong> humans. Categories include: Known, Reasonably Anticipated, <strong>and</strong> others. (Report on Carcinogens,Eleventh Edition; U.S. Department of Health <strong>and</strong> Human Services, Public Health Service, National ToxicologyProgram.) Not all chemicals have been rated by IARC or NTP.‡To date, neither the NTP nor IARC have classified most endocrine disruptors as carcinogens in humans. List ofendocrine disruptors from: Brody JG, Rude l RA (2003). Environmental pollutants <strong>and</strong> breast cancer. EnvironmentalHealth Perspectives 111: 1007-1019.What can we do about <strong>pesticides</strong>?Support organic agriculture at home <strong>and</strong> in the schoolsto reduce exposure to hormonally-active pesticideresidues <strong>and</strong> find alternatives to pesticide use in yourdaily life.Visit www.panna.org for more information.Support bans of the cosmetic – purely aesthetic – useof <strong>pesticides</strong>, meaning, where the weed or pest posesno danger to human health, the environment orproperty. The cities of San Francisco <strong>and</strong> Oakl<strong>and</strong> inCalifornia have banned the use of <strong>pesticides</strong> in theirparks for years <strong>and</strong> Canadians are actively pushing forbans in municipalities. What about your town?Pesticides may disrupt the endocrine systems of childrenduring critical stages of development <strong>and</strong> contribute tolater-life breast cancer risk or to the early onset ofpuberty, also a risk factor for breast cancer.Visit www.breastcancerfund.org/pubertyreport to learnmore.http://www.pureprevention.org/documents/<strong>pesticides</strong>_<strong>and</strong>_breast_cancer_2007.10.11.pdf☻☻☻☻☻62-- Traditional African Clinic July 2013
Biological cause of BlackWomen's Deadly CancerSeptember 6, 2007A new study gives a possible explanation for why breastcancer is more deadly in black women: They are morelikely to have tumors that do not respond to the hormonebasedtreatments that help many others with the disease.The study is the largest yet to link a biological factor tothe racial disparity, which also has been blamed on blackwomen getting fewer mammograms <strong>and</strong> less aggressivetreatment.“This puts biology more to the forefront,” said Dr. JulieGralow, a cancer specialist at the University ofWashington School of Medicine familiar with the work.“It’s not just access to care, access to treatment <strong>and</strong> otherfactors that have been implicated in the past.”The study was led by Dr. M. Catherine Lee of theUniversity of Michigan Comprehensive Cancer Center<strong>and</strong> is to be presented at a conference starting Friday inSan Francisco, organized by the American Society ofClinical Oncology <strong>and</strong> other cancer groups.Breast cancer is the most <strong>com</strong>mon cancer in Americanwomen. An estimated 178,480 new cases <strong>and</strong> 40,460deaths from it are expected in the United States this year.More likely to dieBlacks are less likely than whites to develop breast cancerbut are more likely to die from it, doctors have longknown. Blacks also are diagnosed at younger ages <strong>and</strong> atlater stages of disease.Researchers for the first time used the National CancerData Base, a tumor registry maintained by the AmericanCollege of Surgeons, to explore these issues, using morethan 170,000 cases diagnosed in 1998. Ten percent werein black women.The study focused on the 95,500 women whose cancerswere invasive rather than still confined to a milk duct.About 39 percent of such tumors in black women wereestrogen receptor-negative, or ER-negative, <strong>com</strong>paredwith 22 percent of those in white women.Estrogen helps tumors grow. Drugs that block thishormone, like tamoxifen <strong>and</strong> a newer class of medicationscalled aromatase inhibitors, work against these cancers.ER-negative tumors are resistant to such therapies <strong>and</strong>harder to treat. Other tools like chemotherapy, radiation<strong>and</strong> targeted biological drugs then be<strong>com</strong>e moreimportant for such women, <strong>and</strong> doctors should considerthis when they evaluate black women with the disease,63-- Traditional African Clinic July 2013Lee said.In the study, ER-negative tumors were more <strong>com</strong>mon inblack women at every stage of disease <strong>and</strong> at all ages.For example, only 17 percent of early stage tumors inwhite women were ER-negative, but 31 percent in blackwomen were. Of the most advanced cancers, 31 percentin whites <strong>and</strong> 46 percent in blacks were ER-negative.Cancer more advanced when diagnosedEchoing previous research, the new study found thatblack women were diagnosed at younger ages — anaverage of 57 years old versus 62 for white women —<strong>and</strong> with more advanced disease: Only 29 percent hadearly stage tumors versus 42 percent of white women.They also had larger tumors <strong>and</strong> more cell traits that aresigns of a poor prognosis.Smaller studies have suggested biological differencesbetween breast cancer in blacks <strong>and</strong> whites. Earlier thisyear, the Carolina Breast Cancer Study found that youngblack women were more likely to have an aggressiveform called the basal-like subtype.Last fall, two studies by researchers from the Universityof Texas M. D. Anderson Cancer Center found thatblack women were more likely to have larger, laterstagetumors <strong>and</strong> lower survival rates than Hispanic <strong>and</strong>white women given similar treatments.But these findings do not mean that differences inscreening <strong>and</strong> health care are not contributing to thetrend, especially in certain parts of the country, said Dr.Wendy Woodward, a breast cancer specialist at M.D.Anderson.“You really have to kind of go at the problem from allangles. If you solve the access problem <strong>and</strong> women<strong>com</strong>e in <strong>and</strong> you don’t have an adequate therapy forthem, you haven’t taken a step forward,” she said.Dr. Len Lichtenfeld, deputy chief medical officer of theAmerican Cancer Society, agreed. Racial disparity inbreast cancer survival did not appear until the mid-1980s, suggesting that much of it is due to lack ofscreening mammograms <strong>and</strong> access to care, he said.http://www.nbcnews.<strong>com</strong>/health/biological-cause-blackwomens-deadly-cancer-1C9468040☻☻☻☻☻