CAGE PROCESSING in Animal Facilities - Felasa

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„Musculoskeletal Load in and Highly Repetitive Actions of Animal Facility Washroom Employees“ 2011, Journalof the American Association for Laboratory Animal Science (AALAS) from the Helmholz-Zentrum forHealth and Environment Neuherberg and the Institute for occupational safety of the German Statutory AccidentInsurance (Deutsche Gesetzliche Unfallversicherung (IFA) - former BGIA)2003 ILAR Magazine entitled „Engineering Controls and Facility Design“- An Ergonomic Process for the Careand Use of Research Animals”.11 Terms / DefinitionsAnimal facilityThis term includes all rooms necessary for operating an animal facility, also those for dispensing and disposal,like animal rooms, wash-up area / processing centre, halls, storage rooms, engineering rooms, locks, and alsolaboratories.Animal housing areaThe rooms in which the animals are housed.AOX compoundsAdsorbable organically bound halogens are generated by excess active chlorine when permuted with organicdirt components. The resulting halogenated hydrocarbons are not ecologically favourable.Bisphenol ABisphenol A is one of the monomers (reactive molecule) used for generating polycarbonate.Boiling delayPlease refer to: Danger to life due to boiling delay.CarryoverWith failings in process management or deficiencies in machine construction, it is possible that residual soilingor detergent solution of a preceding washing step is carried over to already washed items.CFUColony forming unityChlorine-induced pittingChlorine-induced corrosion of hollows in metal surfaces covered with passive layers.Collection binWhen cages are emptied, the bedding is collected or temporarily stored in collection bins. These can either bebig plastic bags, bulk containers or vacuum containers.Correction chemicalsAdditives in steam to avoid, for example, corrosion inside steam pipes.Danger to life due to boiling delayAfter steam sterilisation, liquids are cooled by means of “back pressure” that is significantly higher than boilingpressure. When the cooling process is finished, the back pressure is lowered to atmospheric pressure. Insufficientlycooled liquids can then have a temperature higher than boiling temperature without actually boiling. Allit needs for the liquids to suddenly start boiling is a trigger. Such a trigger can be a vibration when the load ismoved out of the chamber. A sudden release of steam can result in boiling over or even bursting containers.Hot liquids can be spread about. The huge mass of a steam sterilisation load poses a risk of life threateningscald burns when liquids are insufficiently cooled.DecontaminationDecontamination describes the process of removing soiling (washing process) and reducing the number ofviable microorganisms to a degree necessary for further processing or use of an object.68Cage Processing in Animal Facilities · 4th issue · 2013
Detergent liquor / detergent solutionDescribes the amount of tank water mixed with detergents that is circulated in the recirculation system of awasher.Disinfection of surfacesDisinfection of surfaces means a specific chemical elimination or inactivation of certain unwanted microorganismsin defined quantities. This is achieved by an irreversible act on the structure or metabolism of the microorganismsin order to prevent them from proliferating, thereby averting a danger of infection. The surfaces canbe disinfected either by wiping or, when surfaces are visually clean, by spraying them.Dumping deviceA permanently installed or mobile station for emptying cage bases of dirty bedding. This includes passively (bygravity) and actively (by suction) operating devices (e.g. dumping hoppers).Electrical conductivity measurementThe electrical conductivity of diluted solutions is a sum parameter for dissociated solutes (ions). The extent ofconductivity depends on the degree of concentration and dissociation of the ions as well as on the temperatureand solute-specific velocity of migration. Measuring the conductivity can help define the concentration ofdissolved process chemicals.Environmental enrichmentThese are products added to the cages in order to enrich the living space of animals. In general, this includesall products that meet this purpose and fit into the cages, especially pulp products, wood shavings, small plasticand wood houses, wooden chewing sticks, etc.ErgonomicsThe science of human work performance capabilities and limits. In this context it means the interaction of manand machine, the physical impact on the operating staff in particular.Evaporative heat lossWhen steam sterilising, the thus generated condensate, due to evacuation, vaporises after the steam sterilisationprocess is finished. The condensate cools down (evaporation). For a fully drying of items, ambient heatmust be fed to the process, for example from the item itself. The drying result depends very much on the availableamount of heat. With bigger amounts of condensate, like in cages, there might not be enough heat left toensure a complete drying.Fine dustDusts with particle dimensions from 0,3 to 10 μm. These particles are respirable and can hardly be withheld bythe nasal mucosa. Thus, substances that are not harmful in themselves can also pose a health risk.GLPGood Laboratory PracticeGMOGenetically modified organismsHygroscopic condensation/OverheatingHygroscopic material (e.g. bedding, feed), which was loaded extremely dry into a steam sterilizer chamber, is frequentlyaffected by overheating. This leads to the so called hygroscopic condensation: The hygroscopic materialalready reached ireached the temperature of the surrounding steam and still tries to increase its relative humidity.This is achieved through condensing steam. The released condensation heat results in local overheating. Thedryer the initial state of the material the greater the effect of overheating via hygroscopic condensation.Items for processingAll items to be processed in an animal facility (please refer to the figure in chapter 2).Cage Processing in Animal Facilities · 4th issue · 2013 69
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CAGE PROCESSINGin Animal Facilities
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CAGE PROCESSINGin Animal Facilities
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Index1 Introduction ...............
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7.1 Requirements ..................
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2 Cage processing cyclesThe followi
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3.2 Materials for processingWhen de
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• They should be easy and conveni
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• Height-adjustable shelves ensur
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Table 4-2Option Advantages Disadvan
Page 19 and 20: Below you will find a description o
Page 21 and 22: Figure 4-10 Tunnel cage washer4.3.1
Page 23 and 24: WashingHot water mixed with deterge
Page 25 and 26: Loading systemsIn cabinet cage wash
Page 27 and 28: 4.3.2.1.3 Rinse aidRinse aids shoul
Page 29 and 30: Semiautomaticdispensing*bedding is
Page 31 and 32: Semi-automaticsystemsmultiple filli
Page 33 and 34: PermissionsWith frequent changes in
Page 35 and 36: 4.6.2.1 Basic lock types for H 2O 2
Page 37 and 38: configurations can thus require ind
Page 39 and 40: 4.6.3.2 Processual requirementsPAA
Page 41 and 42: Lead mg/l -heavy metal residues (ex
Page 43 and 44: For reasons of odour, exhaust air o
Page 45 and 46: 5.6 Installation data and consumpti
Page 47 and 48: 6.2 Start up of operationIt is part
Page 49 and 50: 6.9 Routine checks and measuresThe
Page 51 and 52: 7.2.1.1.2 Test setup1 inside at the
Page 53 and 54: 7.2.2 Test procedures for evaluatin
Page 55 and 56: surfaces stay soil free. For an eve
Page 57 and 58: 7.4 Test procedure for confirming t
Page 59 and 60: Table 7-6WasherItems for processing
Page 61 and 62: with rinse aid, for example, can be
Page 63 and 64: 9 Potential defects and damages in
Page 65 and 66: Table 9-3Source and causesStress /
Page 67 and 68: Table 9-6Sources and causesWashing
Page 69: DIN 1986:Technical Rules for Drinki
Page 73 and 74: ProcessingProcessing means washing,
Page 75 and 76: Final provisions:1. This brochure d
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CAGE PROCESSING in Animal Facilities - Felasa

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