usiness year <strong>2012</strong>group management reportnet sales of EUR 3,592 million, this increasingly significantregion accounts for around 24% of total sales. TheEurope region posted a slight increase in sales (+3.9%) toEUR 4,194 million. Around 29% of group sales are thusgenerated in this region.Net sales by region(in millions of EUR) <strong>2012</strong> 2011 ChangeAmericas 6,905 6,087 13.4%Europe 4,194 4,037 3.9%Asia, Australasia, Africa (AAA) 3,592 3,047 17.9%The sales of our Human Pharmaceuticals business totalledEUR 13,080 million in the last financial year, apleasing increase of around 12% (7.7% after adjustmentfor exchange rate effects). With an 89% share of totalsales, Human Pharmaceuticals is <strong>Boehringer</strong> <strong>Ingelheim</strong>’slargest business. Within this business, the PrescriptionMedicines division generated sales of EUR 11,405 million,an increase of 13.0% (7.1% after adjustment for exchangerate effects). The Consumer Health Care divisionachieved further growth, particularly in the emergingmarkets, generating global sales of EUR 1,505 million,up 7.8% year-on-year (4.7% after adjustment for exchangerate effects). The Biopharmaceuticals division generatedannual sales of EUR 549 million, an increase of 5.8%.Our products in the Animal Health division also performedpositively, with total sales of EUR 1,062 millionand a growth rate of 8.8% (3.8% after adjustment for exchangerate effects), led by the product with the strongestsales, ingelvac circoflex®.Net sales by businesses(in millions of EUR) <strong>2012</strong> 2011 ChangePrescription Medicines 11,405 10,096 13.0%Consumer Health Care 1,505 1,396 7.8%Pharma Chemicals andPharmaceutical Production 162 178 — 9.0%Biopharmaceuticals 549 519 5.8%Animal Health 1,062 976 8.8%Overall, we are satisfied with the development of our salesin <strong>2012</strong>. The positive development of our establishedproducts and the promising product innovations serve toaffirm our actions as a company. At EUR 1,853 million,<strong>Boehringer</strong> <strong>Ingelheim</strong>’s operating income correspondedto a return on sales of 12.6%.Key figures (in millions of EUR) <strong>2012</strong> 2011 ChangeNet sales 14,691 13,171 11.5%Operating income 1,853 2,272 — 18.4%Return on net sales 12.6% 17.3%Research and development (R&D)In line with <strong>Boehringer</strong> <strong>Ingelheim</strong>’s corporate missionstatement, our primary objective is to develop innovativemedicines and treatments for diseases that cannot yet betreated in a satisfactory manner. We are constantly strivingto make an important contribution in areas wherethe need for treatment is high and to attain a leading positionin the major indication areas. In order to achievethis goal, we ensure that we are always up-to-date withstrategically important technologies and systematicallyresearch new key technological approaches. In addition,we believe in using the expertise of academic groups,public research facilities and biotech companies, andhave set up a global network.In the <strong>2012</strong> financial year, we employed an average of7,492 staff at our R&D sites. A total of around EUR2.8 billion was invested in the research and developmentof new drugs. This equates to 19.0% of group sales andthus reaches the level of research and development activitiesof the previous year.<strong>Boehringer</strong> <strong>Ingelheim</strong>’s successful research and developmentactivities and our innovative strength have alwaysprovided the basis and foundation for our positive economicdevelopment in previous years. In-house researchand development will remain a top priority in the future.One example of the rigorous implementation of ourstrategy is our investment of around EUR 50 million inbuilding a pilot facility for the production of newly developedpharmaceutical active ingredients in Biberach,Germany. Construction of the new technical centre willensure provision of the necessary amounts of new activeBusiness and operating environment23
ingredients for clinical trials, and is scheduled for completionat the start of 2014.Human PharmaceuticalsResearch and development activities, with our large researchsites in Germany (Biberach), the USA (Ridgefield)and Austria (Vienna), were focused on the following indicationareas:• Respiratory diseases• Cardiometabolic disorders(cardiovascular and metabolic diseases)• Oncology• Diseases of the central nervous system• Immunology• Infectious diseasesThe <strong>2012</strong> financial year saw the launch of the “DiseaseMap 2025”, which is aimed at constantly reviewing thefocus of the Prescription Medicines division with regardto indication areas and diseases to be treated. In a fastchangingexternal environment, it stipulates targets andcore areas in research, development and medicine wherewe want to develop our division. In the context of thisextensive review, <strong>Boehringer</strong> <strong>Ingelheim</strong> decided to stopits research work on virology. This led to the closure of theresearch site in Laval, Canada, which will be shut downin the first quarter of 2013. The reason for this is a trendtowards treating infectious diseases with vaccinations,an area in which <strong>Boehringer</strong> <strong>Ingelheim</strong> is not active.<strong>Boehringer</strong> <strong>Ingelheim</strong> is one of the world’s leading pharmaceuticalcompanies in the treatment of respiratorydiseases. So far, the most successful product from inhouseresearch is tiotropium, which has been availablefor ten years under the product name spiriva® and isused to treat chronic obstructive pulmonary diseases(COPD). The company currently has an extensive researchand development pipeline for treatment of COPD, asthma,idiopathic pulmonary fibrosis and lung cancer.Overall, various preparations in early phases of clinicaldevelopment (phase I and II) and additional active ingredientsin late development phases (phase III and approval)are available. One example is the respiratoryproduct olodaterol, a long-acting beta-2 agonist for treatingCOPD. Olodaterol is in the approval process and wasprimarily developed as a combination product for tiotropiumin the long-term treatment of COPD. The test substancenintedanib is a tyrosine kinase inhibitor for treatingidiopathic pulmonary fibrosis (IPF), and has shownpromising results in a clinical phase II study. IPF is arare disease with a high mortality rate a few years afterdiagnosis, meaning that there is a significant medicalneed for effective new treatments. Regarding this substance,admission of patients for the approval-relatedphase III study INPULSIS was completed in the secondquarter of <strong>2012</strong>. The outcome of this study is expectedin 2014. The results of the phase III study PrimoTinA-Asthma showed that asthma patients who retainedsymptoms despite currently known treatment options reducedtheir exacerbations when treated with tiotropiumResearch and development <strong>2012</strong> 2011 2010 2009 2008Expenditure in millions of EUR 2,795 2,516 2,453 2,215 2,109– as % of net sales 19.0 19.1 19.5 17.4 18.2Prescription Medicines expenditure in millions of EUR 2,563 2,372 2,306 2,100 2,016– as % of Prescription Medicines net sales 22.5 23.5 23.8 20.9 22.1Average number of employees 7,492 7,159 7,093 6,934 6,788Investments in tangible assets (without investments in infrastructure) in millions of EUR 139 112 83 125 14524<strong>Boehringer</strong> <strong>Ingelheim</strong> annual report <strong>2012</strong>
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