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www.nuncbrand.com - Always with updated informationCovaLink NH Modules• Developed to bind compoundscovalently to the surfaces• For use with molecules, which are noteasily adsorbed to a passive surface• Agressive washing possible using highionic strength solutions• Low non-specific binding• Reaction site easily accessible• Allows site-specific binding via acarboxylic group of a peptide or thephosphate group in the 5’ end ofnucleic acid• Alphanumeric orientation system• Fit all standard equipment• Free-standing modules• White modules for fluorescence andluminescence applicationsImmuno AssaySchematic chemical and physicalconfiguration of the CovaLink NH surface.The NH groups are spaced from thepolystyrene surface by approx. 2 nm long,chemically defined spacer arms, and arecovalently anchored to the surface.ASchematic illustration of the advantageof orientated covalent immobilizationcontrary to physical adsorption of molecules.A: Covalent coupling may be directed to agroup away from the molecule’s active site tosecure an orientation of the molecule, whichmakes its active site accessible for the targetmolecules (0) added in the liquid phase.B: Physical adsorption involves the risk ofhiding of the active site against the surface(left), or destruction of the active site dueto distortion of the molecule (right) byadsorption.BLiterature:Bulletin Nos: 1, 4, 7, 10, 11Tech Note Nos: 9, 11, 17See Pages 195-196 for full reference list with titles and linksCovaLink Manualwww.nuncbrand.com/go/covalinkmanualAccessories:Immuno Washers Page 76Sealing Tapes Page 178Lids Page 176Contact your local distributoror sales rep. for a copy of theCovalent Binding Brochure.Nunc CovaLink NHModules, framed96 wells per frame. Polystyrene.External dimensions 128 x 86 mmCat. No. 478042 244105 ‡ 453690 ‡Configuration F8 C8 BreakApart C8Plate color Clear Clear WhiteTotal volume, µl/well 400 330 350Suggested working 100 100 100volume, µl/wellTotal surface area, cm²/well 2.7 2.5 2.5Units per pack/case 5/30 5/30 5/30NH = secondary amino group‡ Not available in AmericasAlso available on:www.nuncbrand.com/go/covalentbindingYour Partner inImmunology71