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Table 15.2 Intermittent dosing (luteal phase only) of antidepressants
Treatment Daily dose Duration N Conclusion References
Open label
Escitalopram 10–20 mg 3 cycles 27 � Freeman et al 2005 24
Nefazodone 100–150 mg 1 cycle 3 � Kodesh et al 2001 25
Paroxetine CR 25 mg (cross-over) 2 cycles 20 � Yonkers et al 2006 26
Venlafaxine 75–112.5 mg 2 cycles 11 � Cohen et al 2004 38
RCTs
Clomipramine 25–75 mg 3 cycles 15 �� Sundblad et al 1993 23
Fluoxetine 90 mg (weekly) 3 cycles 167 �� Miner et al 200227 10 or 20 mg 3 cycles 141 �� Cohen et al 200228 Nefazodone 100–400 mg 4 cycles 22 � Landen et al 2001 29
Paroxetine 10 or 20 mg 4 cycles 48 � Steiner et al 2006 30
Paroxetine CR 12.5 or 25 mg 3 cycles 191 �� Steiner et al 2005 31
Sertraline 100 mg (cross-over) 2 cycles 8 � Halbreich and Smoller 199732 50 mg 2 cycles 11 � Young et al 199833 PSYCHOTROPIC THERAPIES 133
50–100 mg (cross-over) 2 cycles 57 � Jermain et al 199934 50–100 mg 3 cycles 115 �� Halbreich et al 200235 25–50 mg 2 cycles 151 �� Kornstein et al 2006 36
L-tryptophan 6 g 3 cycles 37 �� Steinberg et al 1999 37
N � the number of women who were on the active compound.
Conclusion: ��, statistically significant improvement vs placebo; �, quality of evidence limited but positive outcome; �, no statistically significant improvement vs
placebo.