Premenstrual Syndromes : PMS and PMDD - Rutuja :: The site ...

184 INDEX
quality of life (QoL) (Continued)
impact of PMS 39–44
see also rating scales
quantification of PMS 27–36
data collection 34–5
measures of impairment 35
rating scales 28–34, 30–1
rating scales 28–34, 30–1, 152–3
early 28
visual analog scales 28, 29
research criteria 16–18
restriction fragment length polymorphisms 164
reward processing 175
salpingo–oophorectomy 126–7, 156–7, 172
schizophrenia 52
seasonal affective disorder 50
selective serotonin reuptake inhibitors (SSRIs) 22–3,
154–5, 165–6
side-effects 155
serotonergic transmission 72–5
dysfunction, cause of PMS? 24–6, 161
enhancement, drugs other than SRIs 23, 74–5
genetics 162–6
link with GABA 75, 161–2
serotonergic pathway 162
serotonin 72–5, 161–6
historical aspects 6–7
pathophysiology of somatic symptoms 22, 24–5, 75,
161–6
physiology 72–5, 161–6, 163
precursor, L-tryptophan 156, 163
receptors 165–6
SSRIs 154–5, 165–6
storage site 162
transporter, polymorphisms 164–5
serotonin reuptake inhibitors 22–3
actions 22–3, 131
serotonin system 72–5, 162–6
serotonin/norepinephrine reuptake inhibitors
(SNRIs) 154–5
sertraline, clinical trials 42–3, 154–5
single nucleotide polymorphisms 164
single photon emission computed tomography (SPECT)
scan 101, 102
steroidogenic acute regulatory protein (STAR) 83
stressors, HPA axis 87–8, 175
substrate (for PMS) 173–5
surgery, hysterectomy and salpingo–oophorectomy 126–7,
156–7, 172
symptoms see clinical presentation of premenstrual
symptoms
testosterone 64, 66
etiology of PMS 109
tibolone 156
treatment of PMS
clinical trials 42–4, 110–11, 134–7
future prospects 171–9
see also specific agents
tryptophan, 11C-5-hydroxytryptophan 101–2
L-tryptophan, serotonin precursor 156, 163
tryptophan hydroxylase 163, 164
visual analog scales 28, 29
vitamins, diet supplements 146, 153
Vitex agnus-castus (chasteberry) 113, 144