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Premenstrual Syndromes : PMS and PMDD - Rutuja :: The site ...

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<strong>PMS</strong>, <strong>and</strong> bilateral oophorectomy alone requires both<br />

progestin <strong>and</strong> estrogen replacement with the risk of<br />

re-stimulating.<br />

CONCLUSION<br />

<strong>Premenstrual</strong> syndrome <strong>and</strong> premenstrual dysphoric<br />

disorder are common <strong>and</strong> often disabling conditions<br />

affecting reproductive-aged women. A formal diagnosis<br />

should be sought whenever premenstrual symptoms<br />

are described. Underlying medical, psychiatric, <strong>and</strong><br />

psychosocial conditions should be excluded, <strong>and</strong> the<br />

premenstrual timing <strong>and</strong> postmenstrual relief of the<br />

symptoms documented prospectively by nightly recording<br />

for at least two cycles. Once a definitive diagnosis is<br />

made, initiation of various treatment strategies can be<br />

effective in alleviating symptoms. Education, lifestyle<br />

change, cognitive behavioral therapy, calcium supplementation,<br />

certain hormonal oral contraceptive preparations,<br />

<strong>and</strong> the diuretic spironolactone can be<br />

effective. <strong>The</strong> administration of a serotonergic antidepressant<br />

is likely to alleviate symptoms <strong>and</strong> improve<br />

significantly the quality of life <strong>and</strong> functional status.<br />

Luteal phase dosing is the preferred method of treatment<br />

with SSRIs in many cases, as discontinuation<br />

symptoms <strong>and</strong> overall side effects are minimized. <strong>The</strong><br />

use of GnRH analogues <strong>and</strong> estradiol patches <strong>and</strong><br />

implants should be reserved for the most severe cases.<br />

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