Premenstrual Syndromes : PMS and PMDD - Rutuja :: The site ...

Extremely severe
Severe
None
Severity
5
4
3
2
1
0
M
5
4
3
2
1
0
O M O M
M
5
4
3
2
1
0
O M O M
M
5
4
3
2
1
0
O M O M
M
5
4
3
2
1
0
O M O M
M O M O M
Figure 2.1 PMS and non-PMS fluctuations of symptoms.
It is also quite widely accepted that individual vulnerability
is an important contributor to the development of
PMS. It should be recognized that, as is increasingly suggested
for affective disorders in general, there are probably
diversified vulnerability traits to PMS. 31 The
diversified vulnerabilities are probably associated with
diversified genotypes, 36 pathophysiological processes
(e.g. 5-hydroxytryptamine (5-HT), �-aminobutyric acid
(GABA) 35 ), and ensuing phenotypes. Once the concept
of multiple phenotypes or subtypes of PMS is accepted,
DIAGNOSIS OF PMS/PMDD 15
a. PMS, classic
b. PMS, symptoms
last most of the cycle
except mid-follicular phase
c. Perimenstrual
syndromes
d. Chronic disorder
e. No symptoms
this is important not only for the diagnosis of PMS but
also for phenotype-targeted treatment, which is the ultimate
purpose of appropriate diagnosis.
The main arguments in support of diversified vulnerabilities
to PMS are:
● Over 200 symptoms have been reported as appearing
premenstrually; they involve many body systems
and none of them is exclusively related to the menstrual
cycle per se. 29,36–38