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136 THE PREMENSTRUAL SYNDROMES
Table 15.4 Anxiolytics
Treatment Daily dose Duration N Conclusion References
RCTs
Alprazolam 1–4 mg/continuous 3 cycles 8 � Dennerstein et al 198660 0.25–4 mg (cross-over)/intermittent 4 cycles 14 �� Smith et al 198761 0.25 mg (cross-over)/intermittent 6 cycles 30 �� Harrison et al 199062 0.75–2.25 mg/intermittent 4 cycles 11 � Schmidt et al 199363 0.25–2 mg/continuous 3 cycles 31 � Berger and Presser 199464 0.25–2 mg/intermittent 3 cycles 56 �� Freeman et al 199565 Buspirone 25–60 mg/intermittent 3 cycles 17 � Rickels et al 198966 10–40 mg/intermittent 4 cycles 19 �� Landen et al 200129 N � the number of women who were on the active compound.
Conclusion: ��, statistically significant improvement vs placebo; �, quality of evidence limited but positive outcome; �, no statistically significant improvement vs
placebo.