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Table 15.3 Intermittent vs continuous dosing of antidepressants
Treatment Daily dose Duration N N Conclusion References
intermittent continuous
Open label
Citalopram 20–40 mg 3 cycles 11 6 � I � C Freeman et al 2002 41
Fluoxetine 20 mg 3 cycles 24 24 � I � C Steiner et al 1997 43
RCTs
Citalopram 10–30 mg 3 cycles 18 34 �� I �C Wikander et al 1998 39
Paroxetine 20 mg 3 cycles 50 51 �� I � C Landen et al 2007 44
Sertraline 50–150 mg 3 cycles 18 13 �� I � C Freeman et al 199940 50–100 mg 3 cycles 35 40 �� I � C Freeman et al 200442 PSYCHOTROPIC THERAPIES 135
N � the number of women who were on the active compound.
Conclusion: ��, statistically significant improvement vs placebo; �, quality of evidence limited but positive outcome; �, no statistically significant improvement vs
placebo; I �C: intermittent equal to or better than continuous.