Male Infertility A child of my own - Andrology Australia

Most men with Klinefelter’s syndrome (about95%) do not produce sperm in their ejaculateand are sterile. However, recent scientific researchsuggests that in up to half of men with Klinefelter’ssyndrome, sperm can develop in small areas of thetestes, which never get into the ejaculate.In many men with Klinefelter’s syndrome, as wellas poor sperm production, testosterone productionby the testis is less than normal. Most men withKlinefelter’s syndrome will need testosteronetreatment at some time in their life.What are Y chromosome deletions?Some men have some genetic material missingfrom their Y chromosome. This has recently beenshown to be the cause of infertility in about one in20 men with low sperm counts (less than 5 millionsperm per millilitre. Tests are now available thatcan pick up these changes on the Y chromosome.What is congenital absence of the vasdeferens (CAVD)?Congenital absence of the vas deferens (CAVD)is a rare genetic problem that causes infertilityin about one in 2500 men. Many men withCAVD have a mutation (genetic change) in thecystic fibrosis gene (cystic fibrosis transmembraneregulator, CFTR).See the AndrologyAustralia guide onAndrogen Defi ciencyfor more informationMALE INFERTILITY 67