Karen Bedard and Karl-Heinz Krause

of NADPH oxidase reduce the organ injury in hemorrhagic shock.
Shock 23: 107–114, 2005.
3. Abid MR, Kachra Z, Spokes KC, Aird WC. NADPH oxidase
activity is required for endothelial cell proliferation and migration.
FEBS Lett 486: 252–256, 2000.
4. Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Activation
of the NADPH oxidase involves the small GTP-binding protein
p21rac1. Nature 353: 668–670, 1991.
5. Abramov AY, Canevari L, Duchen MR. Calcium signals induced
by amyloid beta peptide and their consequences in neurons and
astrocytes in culture. Biochim Biophys Acta 1742: 81–87, 2004.
6. Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari
L, Duchen MR. Expression and modulation of an NADPH oxidase
in mammalian astrocytes. J Neurosci 25: 9176–9184, 2005.
7. Acker H, Dufau E, Huber J, Sylvester D. Indications to an
NADPH oxidase as a possible pO 2 sensor in the rat carotid body.
FEBS Lett 256: 75–78, 1989.
8. Acker T, Fandrey J, Acker H. The good, the bad and the ugly in
oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases. Cardiovasc
Res 71: 195–207, 2006.
9. Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K,
Kawata S. NAD(P)H oxidase plays a crucial role in PDGF-induced
proliferation of hepatic stellate cells. Hepatology 41: 1272–1281,
2005.
10. Adachi T, Weisbrod RM, Pimentel DR, Ying J, Sharov VS,
Schoneich C, Cohen RA. S-glutathiolation by peroxynitrite activates
SERCA during arterial relaxation by nitric oxide. Nat Med 10:
1200–1207, 2004.
11. Adler S, Huang H. Oxidant stress in kidneys of spontaneously
hypertensive rats involves both oxidase overexpression and loss of
extracellular superoxide dismutase. Am J Physiol Renal Physiol
287: F907–F913, 2004.
12. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in
female reproduction. Reprod Biol Endocrinol 3: 28, 2005.
13. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen
species in the pathophysiology of human reproduction. Fertil Steril
79: 829–843, 2003.
14. Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi
H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M.
NAD(P)H oxidases in rat basilar arterial endothelial cells. Stroke
36: 1040–1046, 2005.
15. Ago T, Kitazono T, Ooboshi H, Iyama T, Han YH, Takada J,
Wakisaka M, Ibayashi S, Utsumi H, Iida M. Nox4 as the major
catalytic component of an endothelial NAD(P)H oxidase. Circulation
109: 227–233, 2004.
16. Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY,
Pope S, Nobles M, Segal AW. The large-conductance Ca 2� -activated
K � channel is essential for innate immunity. Nature 427:
853–858, 2004.
17. Aitken J, Fisher H. Reactive oxygen species generation and
human spermatozoa: the balance of benefit and risk. Bioessays 16:
259–267, 1994.
18. Aitken RJ, Baker MA. Oxidative stress and male reproductive
biology. Reprod Fertil Dev 16: 581–588, 2004.
19. Aitken RJ, Buckingham DW, West KM. Reactive oxygen species
and human spermatozoa: analysis of the cellular mechanisms involved
in luminol- and lucigenin-dependent chemiluminescence.
J Cell Physiol 151: 466–477, 1992.
20. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen
species, lipid peroxidation, and human sperm function. Biol Reprod
41: 183–197, 1989.
21. Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B,
Irvine S. Reactive oxygen species generation by human spermatozoa
is induced by exogenous NADPH and inhibited by the flavoprotein
inhibitors diphenylene iodonium and quinacrine. Mol
Reprod Dev 47: 468–482, 1997.
22. Aitken RJ, West KM. Analysis of the relationship between reactive
oxygen species production and leucocyte infiltration in fractions
of human semen separated on Percoll gradients. Int J Androl
13: 433–451, 1990.
23. Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov
V, Ross C, Blecha F, Dinauer M, Fisher AB. Endothelial
THE NOX FAMILY OF ROS-GENERATING NADPH OXIDASES 289
Physiol Rev VOL 87 JANUARY 2007 www.prv.org
NADPH oxidase as the source of oxidants in lungs exposed to
ischemia or high K � . Circ Res 83: 730–737, 1998.
24. Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R,
Brandes RP. Direct interaction of the novel Nox proteins with
p22phox is required for the formation of a functionally active
NADPH oxidase. J Biol Chem 279: 45935–45941, 2004.
25. Ambasta RK, Schreiber JG, Janiszewski M, Busse R, Brandes
RP. Noxa1 is a central component of the smooth muscle NADPH
oxidase in mice. Free Radic Biol Med 41: 193–201, 2006.
26. Ambruso DR, Cusack N, Thurman G. NADPH oxidase activity of
neutrophil specific granules: requirements for cytosolic components
and evidence of assembly during cell activation. Mol Genet
Metab 81: 313–321, 2004.
27. Ameziane-El-Hassani R, Morand S, Boucher JL, Frapart YM,
Apostolou D, Agnandji D, Gnidehou S, Ohayon R, Noel-Hudson
MS, Francon J, Lalaoui K, Virion A, Dupuy C. Dual oxidase-2
has an intrinsic Ca 2� -dependent H 2O 2-generating activity.
J Biol Chem 280: 30046–30054, 2005.
28. Anrather J, Racchumi G, Iadecola C. NF-kappaB regulates
phagocytic NADPH oxidase by inducing the expression of
gp91phox. J Biol Chem 281: 5657–5667, 2006.
29. Arakawa N, Katsuyama M, Matsuno K, Urao N, Tabuchi Y,
Okigaki M, Matsubara H, Yabe-Nishimura C. Novel transcripts
of NOX1 is regulated by alternative promoters and expressed under
phenotypic modulation of vascular smooth muscle cells. Biochem
J. In press.
30. Arbiser JL, Petros J, Klafter R, Govindajaran B, McLaughlin
ER, Brown LF, Cohen C, Moses M, Kilroy S, Arnold RS,
Lambeth JD. Reactive oxygen generated by Nox1 triggers the
angiogenic switch. Proc Natl Acad Sci USA 99: 715–720, 2002.
31. Archer SL, Huang J, Henry T, Peterson D, Weir EK. A redoxbased
O 2 sensor in rat pulmonary vasculature. Circ Res 73: 1100–
1112, 1993.
32. Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R,
Nelson DP, Dinauer MC, Weir EK. O 2 sensing is preserved in
mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl
Acad Sci USA 96: 7944–7949, 1999.
33. Arias AA, Dinauer MC, Ding J, Matute JD, Patino PJ. Expression
and activity of polymorphisms in the 67-kDa protein of the
NADPH oxidase system. Biomedica 24: 262–272, 2004.
34. Armstrong JS, Bivalacqua TJ, Chamulitrat W, Sikka S, Hellstrom
WJ. A comparison of the NADPH oxidase in human sperm
and white blood cells. Int J Androl 25: 223–229, 2002.
35. Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu
R, Parthasarathy S, Petros JA, Lambeth JD. Hydrogen peroxide
mediates the cell growth and transformation caused by the
mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98: 5550–5555,
2001.
36. Arteel GE. Oxidants and antioxidants in alcohol-induced liver
disease. Gastroenterology 124: 778–790, 2003.
37. Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T,
Wilcox CS. Effects of NADPH oxidase inhibitor in diabetic nephropathy.
Kidney Int 67: 1890–1898, 2005.
38. Aten RF, Kolodecik TR, Rossi MJ, Debusscher C, Behrman
HR. Prostaglandin F2alpha treatment in vivo, but not in vitro,
stimulates protein kinase C-activated superoxide production by
nonsteroidogenic cells of the rat corpus luteum. Biol Reprod 59:
1069–1076, 1998.
39. Atkins CM, Chen SJ, Klann E, Sweatt JD. Increased phosphorylation
of myelin basic protein during hippocampal long-term potentiation.
J Neurochem 68: 1960–1967, 1997.
40. Atkins CM, Sweatt JD. Reactive oxygen species mediate activitydependent
neuron-glia signaling in output fibers of the hippocampus.
J Neurosci 19: 7241–7248, 1999.
41. Azumi H, Inoue N, Ohashi Y, Terashima M, Mori T, Fujita H,
Awano K, Kobayashi K, Maeda K, Hata K, Shinke T, Kobayashi
S, Hirata K, Kawashima S, Itabe H, Hayashi Y, Imajoh-
Ohmi S, Itoh H, Yokoyama M. Superoxide generation in directional
coronary atherectomy specimens of patients with angina
pectoris: important role of NAD(P)H oxidase. Arterioscler Thromb
Vasc Biol 22: 1838–1844, 2002.
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