Karen Bedard and Karl-Heinz Krause

888. Tsunawaki S, Kagara S, Yoshikawa K, Yoshida LS, Kuratsuji
T, Namiki H. Involvement of p40phox in activation of phagocyte
NADPH oxidase through association of its carboxyl-terminal, but
not its amino-terminal, with p67phox. J Exp Med 184: 893–902,
1996.
889. Tsunawaki S, Mizunari H, Nagata M, Tatsuzawa O, Kuratsuji
T. A novel cytosolic component, p40phox, of respiratory burst
oxidase associates with p67phox and is absent in patients with
chronic granulomatous disease who lack p67phox. Biochem Biophys
Res Commun 199: 1378–1387, 1994.
890. Uchikura K, Wada T, Hoshino S, Nagakawa Y, Aiko T, Bulkley
GB, Klein AS, Sun Z. Lipopolysaccharides induced increases in
Fas ligand expression by Kupffer cells via mechanisms dependent
on reactive oxygen species. Am J Physiol Gastrointest Liver
Physiol 287: G620–G626, 2004.
891. Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H. The
NADPH oxidase Nox3 constitutively produces superoxide in a
p22phox-dependent manner: its regulation by oxidase organizers
and activators. J Biol Chem 280: 23328–23339, 2005.
892. Ueyama T, Geiszt M, Leto TL. Involvement of rac1 in activation
of multicomponent nox1- and nox3-based NADPH oxidases. Mol
Cell Biol 26: 2160–2174, 2006.
893. Uhlemann AC, Szlezak NA, Vonthein R, Tomiuk J, Emmer SA,
Lell B, Kremsner PG, Kun JF. DNA phasing by TA dinucleotide
microsatellite length determines in vitro and in vivo expression of
the gp91phox subunit of NADPH oxidase and mediates protection
against severe malaria. J Infect Dis 189: 2227–2234, 2004.
894. Uhlinger DJ, Tyagi SR, Inge KL, Lambeth JD. The respiratory
burst oxidase of human neutrophils. Guanine nucleotides and arachidonate
regulate the assembly of a multicomponent complex in a
semirecombinant cell-free system. J Biol Chem 268: 8624–8631,
1993.
895. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38
Mitogen-activated protein kinase is a critical component of the
redox-sensitive signaling pathways activated by angiotensin II.
Role in vascular smooth muscle cell hypertrophy. J Biol Chem 273:
15022–15029, 1998.
896. Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fujimoto
M, Quinn MT, Pagano PJ, Johnson C, Alexander RW. Novel
role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial
growth factor-induced signaling and angiogenesis. Circ Res
91: 1160–1167, 2002.
897. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling
KK. p22phox is a critical component of the superoxide-generating
NADH/NADPH oxidase system and regulates angiotensin II-induced
hypertrophy in vascular smooth muscle cells. J Biol Chem
271: 23317–23321, 1996.
898. Vaissiere C, Le Cabec V, Maridonneau-Parini I. NADPH oxidase
is functionally assembled in specific granules during activation
of human neutrophils. J Leukoc Biol 65: 629–634, 1999.
899. Valencia A, Kochevar IE. Ultraviolet A induces apoptosis via
reactive oxygen species in a model for Smith-Lemli-Opitz syndrome.
Free Radic Biol Med 40: 641–650, 2006.
900. Vallet P, Charnay Y, Steger K, Ogier-Denis E, Kovari E, Herrmann
F, Michel JP, Szanto I. Neuronal expression of the NADPH
oxidase NOX4, its regulation in mouse experimental brain ischemia.
Neuroscience 132: 233–238, 2005.
901. Van Buul JD, Fernandez-Borja M, Anthony EC, Hordijk PL.
Expression and localization of NOX2 and NOX4 in primary human
endothelial cells. Antioxid Redox Signal 7: 308–317, 2005.
902. Van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts
E, Joosten LA, van Lent PL, Coenen-de Roo CJ, Cuzzocrea S,
Segal BH, Holland SM, van den Berg WB. Deficiency of NADPH
oxidase components p47phox and gp91phox caused granulomatous
synovitis and increased connective tissue destruction in experimental
arthritis models. Am J Pathol 163: 1525–1537, 2003.
903. Van der Goes A, Brouwer J, Hoekstra K, Roos D, van den Berg
TK, Dijkstra CD. Reactive oxygen species are required for the
phagocytosis of myelin by macrophages. J Neuroimmunol 92:
67–75, 1998.
904. Van der Veen RC, Dietlin TA, Hofman FM, Pen L, Segal BH,
Holland SM. Superoxide prevents nitric oxide-mediated suppression
of helper T lymphocytes: decreased autoimmune encephalo-
THE NOX FAMILY OF ROS-GENERATING NADPH OXIDASES 311
Physiol Rev VOL 87 JANUARY 2007 www.prv.org
myelitis in nicotinamide adenine dinucleotide phosphate oxidase
knockout mice. J Immunol 164: 5177–5183, 2000.
905. Van Klaveren RJ, Roelant C, Boogaerts M, Demedts M, Nemery
B. Involvement of an NAD(P)H oxidase-like enzyme in superoxide
anion and hydrogen peroxide generation by rat type II cells.
Thorax 52: 465–471, 1997.
906. Van Lent PL, Nabbe KC, Blom AB, Sloetjes A, Holthuysen AE,
Kolls J, Van De Loo FA, Holland SM, Van Den Berg WB.
NADPH-oxidase-driven oxygen radical production determines
chondrocyte death and partly regulates metalloproteinase-mediated
cartilage matrix degradation during interferon-gamma-stimulated
immune complex arthritis. Arthritis Res Ther 7: R885–895,
2005.
907. Van Reyk DM, King NJ, Dinauer MC, Hunt NH. The intracellular
oxidation of 2�,7�-dichlorofluorescin in murine T lymphocytes.
Free Radical Biol Med 30: 82–88, 2001.
908. VanWijk MJ, Nieuwland R, Boer K, van der Post JA, VanBavel
E, Sturk A. Microparticle subpopulations are increased in preeclampsia:
possible involvement in vascular dysfunction? Am J
Obstet Gynecol 187: 450–456, 2002.
909. Vanwijk MJ, Svedas E, Boer K, Nieuwland R, Vanbavel E,
Kublickiene KR. Isolated microparticles, but not whole plasma,
from women with preeclampsia impair endothelium-dependent relaxation
in isolated myometrial arteries from healthy pregnant
women. Am J Obstet Gynecol 187: 1686–1693, 2002.
910. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya
AS. Reactive oxygen species produced by NAD(P)H
oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem
279: 34643–34654, 2004.
911. Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK.
Oxidative stress and dysregulation of superoxide dismutase and
NADPH oxidase in renal insufficiency. Kidney Int 63: 179–185,
2003.
912. Vega-Saenz de Miera E, Rudy B. Modulation of K � channels by
hydrogen peroxide. Biochem Biophys Res Commun 186: 1681–
1687, 1992.
913. Vejrazka M, Micek R, Stipek S. Apocynin inhibits NADPH oxidase
in phagocytes but stimulates ROS production in non-phagocytic
cells. Biochim Biophys Acta 1722: 143–147, 2005.
914. Verbeek W, Lekstrom-Himes J, Park DJ, Dang PM, Vuong PT,
Kawano S, Babior BM, Xanthopoulos K, Koeffler HP. Myeloid
transcription factor C/EBP� is involved in the positive regulation of
lactoferrin gene expression in neutrophils. Blood 94: 3141–3150,
1999.
915. Vernet P, Fulton N, Wallace C, Aitken RJ. Analysis of reactive
oxygen species generating systems in rat epididymal spermatozoa.
Biol Reprod 65: 1102–1113, 2001.
916. Viedt C, Fei J, Krieger-Brauer HI, Brandes RP, Teupser D,
Kamimura M, Katus HA, Kreuzer J. Role of p22phox in angiotensin
II and platelet-derived growth factor AA induced activator
protein 1 activation in vascular smooth muscle cells. J Mol Med 82:
31–38, 2004.
917. Vignais PV. The superoxide-generating NADPH oxidase: structural
aspects and activation mechanism. Cell Mol Life Sci 59: 1428–1459,
2002.
918. Vigone MC, Fugazzola L, Zamproni I, Passoni A, Di Candia S,
Chiumello G, Persani L, Weber G. Persistent mild hypothyroidism
associated with novel sequence variants of the DUOX2 gene in
two siblings. Hum Mutat 26: 395, 2005.
919. Vilhardt F, Plastre O, Sawada M, Suzuki K, Wiznerowicz M,
Kiyokawa E, Trono D, Krause KH. The HIV-1 Nef protein and
phagocyte NADPH oxidase activation. J Biol Chem 277: 42136–
42143, 2002.
920. Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL. Role of
NAD(P)H oxidase on vascular alterations in angiotensin II-infused
mice. J Hypertens 22: 535–542, 2004.
921. Virion A, Michot JL, Deme D, Kaniewski J, Pommier J.
NADPH-dependent H 2O 2 generation and peroxidase activity in thyroid
particular fraction. Mol Cell Endocrinol 36: 95–105, 1984.
922. Volkman DJ, Buescher ES, Gallin JI, Fauci AS. B cell lines as
models for inherited phagocytic diseases: abnormal superoxide
generation in chronic granulomatous disease and giant granules in
Chediak-Higashi syndrome. J Immunol 133: 3006–3009, 1984.
Downloaded from
physrev.physiology.org
on February 2, 2010