Protocolo-TEA-final

ControlEarly Intensive BehavioralInterventionIQStandardized tests ofintelligenceFollow-up: 1-3 yearsThe mean IQ in thecontrolgroups was0.30 standarddeviationshigher at posttreatmentcompared to pretreatment(0.03 lower to 0.63higher) 1The mean IQ in the172intervention(5 studies 3 )groups was0.76 standard deviationshigher(0.4 to 1.11 higher) 2⊕⊕low 4,5*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk inthe comparison group and the relative effect of the intervention (and its 95% CI).CI: Confidence intervalGRADE Working Group grades of evidenceHigh quality: Further research is very unlikely to change our confidence in the estimate of effect.Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.Very low quality: We are very uncertain about the estimate1 This is a difference in standard deviations calculated for the TAU group from change scores before and after the intervention period.2 This is a difference between standard deviations because only raw scores were reported).108