Medicinus - Dexa Medica

ngan perawatan kulit terkini adalah menggabungkan
diet dengan konsumsi suplemen vitamin dan
AO. Konsep pendekatan inside-out ini memicu
pengembangan produk yang dikategorikan sebagai
nutricosmetic. 2 Dalam konteks ini, dikenalkan
istilah nutraceutical 2,19 yang mengacu pada istilah
cosmeceutical yakni produk suplemen vitamin oral
untuk kesehatan.
KESIMPULAN
Radikal bebas/ROS akan terus menerus terbentuk
Daftar Pustaka
1. Bjelakovic G, Gluud C. Surviving antioxidants supplements. JNCI,
2007; 99 (10): 742-3
2. Draelos ZD. Nutrition and enhancing youthful- appearing skin. Clinics
in Dermatology 2010; 28: 400–8
3. Zussman J, Ahdout J, Kim J. Vitamins and photoaging:
Do scientific data support their use? J Am Acad Dermatol
10.1016/j.jaad.2009.07.037. ARTICLE IN PRESS.xa09rfHc36omk
-rB0wad2lta,e9o cUl
4. Pinnell SR. Cutaneous photodamage, oxidative stress, and topical
antioxidant protection. J Am Acad Dermatol 2003; 48: 1-19
5. Moini H, Packer L, Saris N-E L. antioxidant and prooxidant activities
of α lipoic acid and dihydrolipoic acid. Toxicology and Applied Pharmacology
2002; 182: 84-90
6. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and
the generative diseases of aging. Proc. Natl. Acad. Sci. USA 1993; 90:
7915-22
7. Baumann L. Antioxidants. In: Cosmetic Dermatology: Principles and
Practice. Hongkong: McGraw-Hill; 2002.p.105-16
8. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al.
Mechanisms of photoaging and chronological skin aging. Arch Dermatol.
2002; 138:1462-70
9. Hakozaki T, Date A, Yoshii T, Toyokuni S, Yasui H, Sakurai H. Visualization
and characterization of UVB-induced reactive oxygen species
in a human skin equivalent model. Arch Dermatol Res 2008;
300 (Suppl 1): S51–S56. DOI 10.1007/s00403-007-0804-3
10. Ali M. The oxidative-dysoxygenative model of aging. J Integrative
Medicine. 2003; 7(1):1-19. Available from http://www.jintmed.
com/vol7.htm
11. Rabe JH, Mamelak AJ, McElgunn PJS, Morison WL, Sauder DN. Photoaging:
Mechanism and repair. J Am Acad Dermatol 2006; 55: 1-19
12. Riad HMA. The role of antioxidants in dermatology. Gulf J Dermatol
2001; 8 (2): 1-14
13. Angerhofer CK, Maes D, Giacomoni PU. The use of natural compounds
and botanicals in the development of anti-aging skin care
products. In: Dayan N, ed. Skin Aging Handbook: an integrated Approach
to Biochemistry and Product Development. New York: William
Andrew Inc; 2008.p.205-63
14. DeBuys HV, Levy SB, Murray JC, Madey DL, Pinnel SR. Modern approach
to photoprotection. Derm Clinics 2000; 18 (4): 577-90
15. Verschooten L, Claerhout S, Van Laethem A, Agostinis P, Garmyn M.
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and Photobiology 2006; 82:1016-23
16. Masaki H. Role of antioxidants in the skin: Anti-aging effects. J Derm
Sci 2010; 58:85–90
leading article
baik melalui proses metabolisme maupun akibat
dampak negatif lingkungan. Radikal bebas tersebut
terkait dengan terjadinya stres oksidatif yang
berperan dalam patogenesis berbagai penyakit
degeneratif termasuk penuaan. Dalam kondisi ini
AO diyakini memainkan peran yang penting. Meski
demikian, memang masih diperlukan penelitian
lebih lanjut untuk menjawab beberapa pertanyaan
yang masih ada. Misalnya kapan waktu paling tepat,
berapa lama dan berapa dosis serta AO mana yang
paling efektif.
17. Prahl S, Kueper T, Biernoth T, Wőhrmann Y, Münster A, Fürstenau M,
et al. Aging skin is functionally anaerobic: Importance of coenzyme
Q10 for anti aging skin care. Bio Factors 2008; 32:245–55. IOS Press.
18. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols:
anti-inflammatory, antioxidant and DNA repair mechanisms.
Arch Dermatol Res 2010; 302:71–83. DOI 10.1007/s00403-009-
1001-3
19. McDaniel CF. Understanding antioxidants. Available from http://
www.fisherinstitute.org/live_pages/antioxidents.php. © 2003 -
2007 Fisher Institute.
20. Yaar M, Gilchrest BA. Aging of skin. In: Freedberg IM, Eisen AZ, Wolff
K, Austen KF, Goldsmith LA, Katz SL, eds. Fitzpatrick’s Dermatology
in General Medicine, 7 th ed. New York: McGraw-Hill; 2008.p.963-75
21. Stahl W, Mukhtar H, Afaq F, Sies H. Vitamins and polyphenols in systemic
photoprotection. In: Gilchrest BA, Krutmann J, eds. Skin Aging.
Germany: Springer-Verlag Berlin Heidelberg 2006.p.113-21
22. Lupo MP. Antioxidants and vitamins in cosmetics. Clinics in Dermatology
2001; 19:467–73
23. Wang SQ, Balagula Y, Osterwalder U. Photoprotection: a review of
the current and future technologie. Dermatologic Therapy 2010; 23:
31–47
24. Shapiro SS, Saliou C. Role of vitamins in skin care. Nutrition
2001;17:839–44. ©Elsevier Science Inc. 2001.
25. Tandon R. Antioxidants: Past and present. Available from http://
www.pharmainfo.net/reviews/antioxidants-past-and-present.
2005; 3(4)
26. Stahl W, Heinrich U, Aust O, Tronnier H, Sies H. Lycopene-rich products
and dietary photoprotection. Photochem. Photobiol. Sci.,
2006; 5:238–42
27. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality
in randomized trials of antioxidant supplements for primary and
secondary prevention. Systematic review and meta-analysis. JAMA
2007; 297(8):842-57. doi:10.1001/jama.297.8.842
28. Gann PH. Randomized trials of antioxidant supplementation for
cancer prevention. First bias, now chance next, cause. JAMA. 2009;
301(1):102-3. Published online December 9, 2008. (doi:10.1001/
jama.2008.863)
29. Asgari MM, Maruti SS, Kushi LH, White E. Antioxidant supplementation
and risk of incident melanomas. Results of a large prospective
cohort study. Arch Dermatol. 2009;145(8):879-82. Available from:
http://archderm.ama-assn.org/cgi/content/full/145/8/879
30. Rosen CF. Topical and systemic photoprotection. Dermatologic
Therapy, 2003; 16:8–15
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