Medicinus - Dexa Medica

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12 tamin E, Zinc, Selenium dan lain–lain. Antioksidan yang berasal dari luar tubuh dapat ditemukan di dalam makanan sehari–hari misalnya Wortel, minyak ikan, hati, jeruk, nanas, sayur–sayuran yang berwarna hijau dan lain–lain. SELOXY AA merupakan preparat antioksidan yang memiliki komposisi Alpha Lipoic Acid , Beta Karoten, Calsium Ascorbate, Zinc Picolinate, Selenium. Alpha Lipoic Acid (ALA) merupakan asam lemak yang mengandung gugus sulfur yang terdapat pada setiap sel tubuh yang dapat membantu menghambat penuaan akibat glycation (reaksi glukosa-protein) sehingga akan mengurangi kerusakan kolagen pada kulit, selain itu ALA merupakan antioksidan yang bersifat universal karena kemampuannya yang bersifat lipofilik (larut dalam lemak) dan hidrofilik (larut dalam air) sehingga mampu menembus membran sel lapisan lemak maupun air. ALA juga mempunyai aktivitas kemampuan antioksidan secara bbiologi dan aktivitas mere-cycle abtioksidan lain (Vitamin C, Vitamin E, Ubikuinone dan Glutathione) serta mampu me-regenerate it self (me-recycle dari bentuk radikal bebas menjadi antioksidan kembali) Beta Carotene merupakan provitamin A yang mempunyai fungsi dapat meredam reaktivitas radikal bebas dan melindungi sel dari kerusakan oksidatif, meningkatkan sistem imun dan dapat menurunkan risiko terjadinya kanker. Calsium ascorbate merupakan bentuk garam dari Ascorbic acid (Vitamin C), sehingga mempunyai efek iritasi yang minimal dilambung, yang mempunyai efektivitas sebagai kofaktor pembentuk kolagen dan dapat meningkatkan elastisitas dan meremajakan kulit. Selenium adalah trace mineral esensial bagi tubuh manusia yang dapat berfungsi sebagai immu- MEDICINUS 24(1), January 2011 nomodulator, detoksifikasi logam berat, anti carcinogenic, selenium dapat dijumpai di daging, ikan, brokoli dan lain-lain. Sedangkan Zinc dapat membantu proses pembentukan struktur dan fungsi membran sel, mempercepat penyembuhan luka, sebagai imunitas seluler, meredam radikal bebas dan membantu penyembuhan infeksi. Komposisi SELOXY AA yang multi antioksidan ini merupakan pilihan tepat untuk dapat meredam radikal bebas dalam tubuh. KESIMPULAN 1. Skin aging adalah proses yang di pengaruhi oleh faktor Internal dan eksternal, yang terperlambat atau hambat. 2. Radikal bebas merupakan salah faktor yang dapat mengakibat terjadi skin aging. 3. Antioksidan dapat meminimalkan kerusakan yang diakibatkan radikal bebas sehingga memperlambat proses skin aging. 4. SELOXY AA merupakan antioksidan yang dapat meredam radikal bebas dengan komposisi Alpha Lipoic Acid , Beta Karoten, Calsium Ascorbate, Zinc Picolinate dan Selenium. Daftar Pustaka 1. Daniel S., et al, Collagen glycation and skin aging. Cosmetics and Toiletries manufacture Worldwide 2. Erin E. Boh, Free Radicals and Aging of the Skin. Cosmetic Dermatology Journal, Desember 2001 Vol.14 No.12 3. Percival Mark, Antioxidants, Nut031 1/96 Rev.10/98 4. Glucotize Scientific Overview, Alpha Lipoic Acid Overview, June 2005
Effect of DLBS3233, an Insulin Sensitizer, on Fructose-Induced Insulin Resistance Rat Florensia Nailufar*,** and Raymond R. Tjandrawinata** *Department of Animal Pharmacology, Division of Protein Biochemistry and Molecular Pharmacology, Dexa Laboratories of Biomolecular Sciences, PT. Dexa Medica ** Dexa Laboratories of Biomolecular Sciences, PT. Dexa Medica ABSTRACT Increased insulin and glucose in the blood plasma is believed to be the beginning of insulin resistance and type 2 diabetes mellitus, which can lead to the development of cardiovascular diseases. In order to elucidate the pharmacological action of DLBS3233, a natural insulin synthesizer, we performed a pharmacodynamic study in Wistar rats (Rattus norvegicus Wistar strain). The rats were divided into three groups (n = 7): control group, insulin-resistant group and treated group. Random glucose, postprandial glucose, fasting glucose, and fasting insulin levels were measured. In addition, total cholesterol, triglycerides (TG), High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL) were also measured to investigate the effect of DLBS3233 on lipid panel. The results showed that DLBS3233 lower the level of blood glucose, insulin, total cholesterol, LDL, and TG while increasing HDL cholesterol in blood significantly. HOMA score was also decreased significantly suggesting that DLBS3233 is a potential insulin sensitizer. INTRODUCTION Diabetes is a chronic disease that occurs when pancreas does not produce enough insulin, or when body cannot effectively use the insulin it produces. It is preceded by long period of asymptomatic hyperglycemia which may lead to serious damage to many of body’s system, including nerves and blood vessels. 1 Diabetes can be caused by too little, resistance to insulin or both of them. Insulin resistance is a condition where insulin sensitivity decreases. This condition affects the ability of insulin hormone to decrease blood glucose level and stimulate usage of glucose in muscle and adipose tissue, which causes high level of blood glucose in blood. Insulin resistance have been increasing worldwide and plays a role in the pathophysiology of the most common human disease including diabetes mellitus type 2, hypertension, obesity, dyslipidemia, and coronary heart disease. 2 It is commonly associated with lipoprotein abnormalities that are risk factors for atherosclerosis, including hypertriglyceridemia, high levels of very low density lipoprotein (VLDL), low levels of high density lipoprotein (HDL), and small dense Low Density Lipoprotein (LDL). These metabolic abnormalities together with hypertension and type 2 diabetes mellitus may cluster in the same individual, constituting a syndrome referred to as the metabolic syndrome X. 3 Here, we investigated DLBS3233, a bioactive fraction containing Lagerstroemia speciosa and Cinnamomum burmanii, in Wistar strain rats. Some previous studies showed that Lagerstroemia speciosa leaves could be used to decrease blood glucose level in diabetic rats and could enhance glucose transport to adipocyte cells as well. 4-5 It possess a few active compounds (such as triterpene and corosolic acid) having a characte-ristic of insulin mimetics which can activate tyrosine kinase as an insulin receptor and inhibit tyrosine phosphatase. On the other hand, several studies have reported that cinnamon has antidiabetic effect on db/db mice and type 2 diabetic patients. 6 Therefore, studying the activity of DLBS3233 would be important to provide a promising treatment for diabetes. In addition, the clinical trial phase I and II of DLBS3233 had been conducted and showed good safety and efficacy profile. MATERIALS AND METHOD Materials original article research DLBS3233 was developed and prepared by Dexa Laboratories of Biomolecular Sciences. Fructose and MEDICINUS 24(1), January 2011 13
Page 3 and 4: Chief Editor Dr. Raymond R. Tjandra
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