EXECUTIVE SUMMARY - GOLD

The Netherlands. J Epidemiol Community
Health 1998;52(2):120-5.
140. Woodhead M, Blasi F, Ewig S, Huchon
G, Ieven M, Ortqvist A, et al. Guidelines for
the management of adult lower respiratory
tract infections. Eur Respir J
2005;26(6):1138-80.
141. Jackson LA, Neuzil KM, Yu O, Benson P,
Barlow WE, Adams AL, et al. Effectiveness
of pneumococcal polysaccharide vaccine in
older adults. N Engl J Med
2003;348(18):1747-55.
142. Prevention of Pneumococcal Disease:
Recommendations of the Advisory
Committee on Immunization Practices
(ACIP). MMWR 1997;46 (RR-08):1-24
http://www.cdc.gov/mmwr/preview/mmwrhtml/00047
135.htm .
143. Alfageme I, Vazquez R, Reyes N, Munoz
J, Fernandez A, Hernandez M, et al. Clinical
efficiacy of anti-pneumococcal vaccination in
patients with COPD. Thorax 2006;61:189-95.
144. Francis RS, May JR, Spicer CC.
Chemotherapy of bronchitis: influence of
penicillin and tetracylcline administered daily,
or intermittently for exacerbations. BMJ
1961;2:979-85.
145. Francis RS, Spicer CC. Chemotherapy in
chronic bronchitis: influence of daily
penicillin and teracycline on exacerbations
and their cost. A report to the research
committee of the British Tuberculosis
Assoication by their Chronic Bronchitis
subcommittee. BMJ 1960;1:297-303.
146. Fletcher CM, Ball JD, Carstairs LW,
Couch AHC, Crofton JM, Edge JR, et al.
Value of chemoprophylaxis and
chemotherapy in early chronic bronchitis. A
report to the Medical Research Council by
their Working Party on trials of chemotherapy
in early chronic bronchitis. BMJ
1966;1(5499)(5499):1317-22.
147. Johnston RN, McNeill RS, Smith DH,
Dempster MB, Nairn JR, Purvis MS, et al.
Five-year winter chemoprophylaxis for
chronic bronchitis. Br Med J
1969;4(678):265-9.
148. Isada CM, Stoller JK. Chronic bronchitis:
the role of antibiotics. In: Niederman MS,
Sarosi GA, Glassroth J, eds. Respiratory
infections: a scientific basis for management.
London: WB Saunders; 1994:621-33.
149. Siafakas NM, Bouros D. Management of
acute exacerbation of chronic obstructive
pulmonary disease. In: Postma DS, Siafakas
NM, eds. Management of chronic obstructive
pulmonary disease. Sheffield: ERS
Monograph; 1998:264-77.
150. Allegra L, Cordaro CI, Grassi C.
Prevention of acute exacerbations of chronic
obstructive bronchitis with carbocysteine
lysine salt monohydrate: a multicenter,
double- blind, placebo-controlled trial.
Respiration 1996;63(3):174-80.
151. Guyatt GH, Townsend M, Kazim F,
Newhouse MT. A controlled trial of ambroxol
in chronic bronchitis. Chest 1987;92(4):618-
20.
152. Petty TL. The National Mucolytic Study.
Results of a randomised, double-blind,
placebo-controlled study of iodinated glycerol
in chronic obstructive bronchitis. Chest
1990;97(1):75-83.
153. Siafakas NM, Vermeire P, Pride NB,
Paoletti P, Gibson J, Howard P, et al. Optimal